back to indexE103: Tech layoffs surge, big tech freezes hiring, optimizing for profits, election preview & more
Chapters
0:0 Jason's new brand deal
1:18 Bestie updates
9:12 "Ligma/Johnson" blunder outside of Twitter HQ
15:38 Surge of tech layoffs at Twitter, Stripe, Lyft, Opendoor, Chime and others; preparing for a longer downturn than originally anticipated
35:28 Macro trends, big tech freezes hiring, how founders can think about the last 3 years and the next 3 years
54:4 Midterm election preview, understanding the shift toward populism
77:32 Science corner: Understanding Meta's AlphaFold competitor
00:00:00.000 |
What the ffff... What are you wearing, Jason? 00:00:02.800 |
What? Oh, Uber had a big week, so this is the Uber-Montclair crossover hat. 00:00:09.360 |
You bought that or I sent it to you? Oh, what? You got the watch and the mug? 00:00:13.120 |
Oh, you don't know about the Apple-Montclair watch? 00:00:22.640 |
You don't know about the new neck tats that are coming from Montclair? 00:00:32.960 |
I'm not saying that I got a $100,000 sponsorship, 00:00:36.720 |
but we don't have a rule in the agreement about logo placement, do we? 00:00:43.280 |
Listen, J. Cal, if anyone was willing to sponsor you, 00:00:45.920 |
every square inch of your clothing would be covered in ads like a race car driver. 00:00:54.960 |
This is $5 plus $17 of shipping from France on Etsy. 00:01:18.800 |
How was everyone's week? What did you guys do this week? 00:01:21.520 |
Just busy, working, trying to be helpful where I can. 00:01:24.880 |
And that'll be the extent of my comments today. 00:01:30.960 |
I've gotten all sorts of inbound from people asking me if I'm like leaving 00:01:37.200 |
We're just, Jason and I are just pitching in and helping out while Elon establishes 00:01:47.440 |
And some of us are just kind of helping out in any way we can. 00:01:56.400 |
But it's been blown up by the media into something much more than it actually is. 00:02:02.800 |
I am still doing my day job, podcasting, investing in 100 companies a year, 00:02:10.160 |
I do want to try talking about one issue that's already public, because it's already been 00:02:14.800 |
So Elon had a tweet this morning about how there's now an advertiser boycott going on. 00:02:20.800 |
And this falls on the heels of a bunch of reports that came out over the last couple 00:02:24.720 |
of days that supposedly there's been a big influx of racist tweets. 00:02:30.640 |
And Jason and I actually saw what was really going on, which was it's all not true. 00:02:35.120 |
I mean, what happened is that within hours of Elon taking over the company on Friday, 00:02:39.200 |
there was a 4chan attack, where basically people from this message board created bots 00:02:44.160 |
to post hundreds of thousands of spam messages that contained racist words and epithets. 00:02:52.720 |
And Yoel, who runs the trust and safety implementation, he met with me and Jason, and Elon directed 00:03:00.560 |
And Yoel actually posted a tweet somewhere about it. 00:03:03.760 |
That's the only reason I feel comfortable talking about it, is because you already posted 00:03:08.480 |
the tweet somewhere, but maybe people haven't seen it, or they haven't connected all the 00:03:12.720 |
But what's really, I think, unfair about this is that, as you've seen, it's not like your 00:03:19.280 |
feed was all of a sudden filled with racist things. 00:03:21.120 |
These were spam accounts or bot accounts that were posting to zero followers. 00:03:25.920 |
They generally have zero followers, or if they do have followers, it's other bot accounts, 00:03:29.920 |
So they're posting racist tweets into the ether, so to speak. 00:03:36.960 |
But then what happens is these activist groups, they're monitoring the fire hose, right? 00:03:42.400 |
And so they publish a report saying that racist tweets have gone up 500% since Elon took over 00:03:48.800 |
The truth is, Elon hasn't even had a chance to change anything about the content moderation 00:03:55.360 |
Like, guys, I haven't changed anything about content moderation. 00:03:59.040 |
Whatever the rules are, they're the same rules that existed prior to him taking over. 00:04:04.320 |
And this is just an organized operation by people who want to create that report. 00:04:10.320 |
So then these activist groups basically publish this report, they feed it to news outlets, 00:04:14.720 |
and then somebody then takes those reports and then feeds them to advertisers, and you 00:04:20.240 |
But I think the point here is that Elon didn't do this. 00:04:23.920 |
This is being manufactured by people who are not operating in good faith. 00:04:27.680 |
They're trying to manufacture an incident that they can then use to hurt the company. 00:04:32.080 |
Yeah, and it was thwarted immediately and fixed. 00:04:34.720 |
Have you guys seen episode 333 of the Lex Friedman podcast? 00:04:38.480 |
He interviews Andrej Karpathy, who is really, I mean, one of the great minds of our time, 00:04:47.600 |
And the question that Lex asked, which Andrej expounded on, which I think is really interesting, 00:04:54.160 |
is, what does the next generation of bots look like? 00:04:58.160 |
And I think where the problem gets very hard for all platforms, so this is not a Twitter-specific 00:05:05.360 |
discussion, is that you can now generate such real, lifelike human images that are unique, 00:05:12.000 |
and you can also generate high-quality text to things like GPT-3 that can essentially 00:05:20.720 |
push the boundaries of a low-level Turing test. 00:05:24.880 |
I think the real problem over time for bots, for spam, for coordinated attacks on any platform, 00:05:33.760 |
is that when you use these tools, you're going to have to become very sophisticated in how you try 00:05:42.000 |
It's a really interesting discussion between two pretty meaningfully smart people. 00:05:47.360 |
Karpathy was the head of autopilot at Tesla, right? 00:05:53.760 |
I have no doubt that Elon is going to do a much better job stopping bots on Twitter once 00:05:59.760 |
he has a chance to do it, because he's got this amazing team of AI engineers, and he's 00:06:07.920 |
You know what I like the most about what I heard this week is the idea that you can do 00:06:12.800 |
either micropayments or subscription to third-party content providers, because I think so much of my 00:06:17.840 |
news feed is delivered to me through the Twitter app, and then I click on an article, and then 00:06:23.600 |
it's like a paywall, or it's some sort of difficulty in accessing the content. 00:06:28.240 |
Having some integration there or some ability to kind of make a micro-purchase to read an 00:06:32.640 |
article is going to be, I think, a super feature. 00:06:35.360 |
The other thing that I would love Twitter to experiment with is if you have a micropayments 00:06:39.440 |
model to publishers, it would be great if you could publish content without a byline, 00:06:44.240 |
a la The Economist, and see what that does to information quality. 00:06:48.640 |
If you do not get any credit to your individual name for writing stuff, but instead it goes 00:06:55.360 |
to the Mass Ted publication, whatever it is, the Times, the Post, I think you could have 00:07:00.480 |
a really important behavior change in how journalists cover the news. 00:07:06.720 |
And if you're paying them enough money, I think that you could probably demand that. 00:07:11.760 |
You know, strip the byline away and just it just says New York Times. 00:07:17.200 |
Yeah, it is a The Economist is a very polarizing gig in journalism for that reason. 00:07:23.760 |
There are going to be actually a lot of journalists who would prefer to have their byline taken off. 00:07:29.360 |
One of the problems with journalism today is even if you're doing reporting in good faith, 00:07:33.920 |
Chamath, and you put your byline on there, harassment, you know, threats, etc, can become 00:07:39.280 |
very acute if you're just covering certain topics. 00:07:41.840 |
And so I actually think a lot of, you know, writers and journalists would opt into this, 00:07:47.360 |
I think they should, because I think the two ends of the spectrum are better than this, 00:07:51.280 |
you know, gross middle that we have the end of this one end of the spectrum is you have 00:07:55.760 |
the New York Times, the Washington Post and The Economist with no byline and no attribution to 00:08:00.720 |
The other end is if you want to build a brand that's based on your name, go start a sub stack. 00:08:04.880 |
And I think that there's a very good balance there. 00:08:08.000 |
And the New York Times could syndicate that as well. 00:08:10.480 |
But if you separate the two, all of a sudden, the news becomes more likely to be truthful news 00:08:19.120 |
The other issue is, you know, for readers, if you do choose to do a no byline publication, 00:08:24.400 |
you're really going to need time to build trust and for people to understand what you're doing, 00:08:28.080 |
because they will think you're taking the byline off in order to pursue a certain agenda, right? 00:08:32.880 |
So that is the the that is the suspicion that can build up. 00:08:35.600 |
The Economist has been able to do this over decades with trusted reporting. 00:08:39.600 |
And sub stack proves that you can have no reputation whatsoever. 00:08:43.120 |
And if you're publishing great content, you can build a great business from scratch. 00:08:46.720 |
So, you know, you don't need to you don't need to pay your dues, 00:08:49.760 |
quote unquote, by getting a byline at the New York Times to be a clever writer. 00:08:53.280 |
You can start that business today and get paid. 00:08:56.240 |
So I think the New York Times should just focus on being the New York Times. 00:08:59.120 |
And sub stack should focus on individual people. 00:09:02.480 |
And I think if you could clean up the middle, that would be much better for all of us. 00:09:06.000 |
Anyways, I'm excited for you guys to help out and pitch in. 00:09:10.160 |
I'd love to come back and use Twitter more often. 00:09:12.240 |
Can we talk about the reporting that happened with the two guys that trolled the journalists 00:09:20.560 |
Because I actually thought that was such an interesting moment this week that all the 00:09:24.880 |
journalists immediately parroted it because it fed their narrative. 00:09:31.840 |
And then several of them, including, I think, Deirdre Bosa from CNBC, 00:09:34.960 |
came out and publicly apologized for that report. 00:09:38.080 |
And if folks listening aren't familiar with what happened, these two guys came out, 00:09:43.200 |
they pretended to be fired Twitter employees on Monday, walked out with a box. 00:09:47.280 |
Oh, what's funnier, I woke up and they were like, Hey, we just got fired. 00:09:53.360 |
You know, the guy's name was one guy's name is Rahul Ligma. 00:09:57.200 |
And the other guy's name was like Mike Johnson. 00:10:01.600 |
So I now here's what's so funny about due diligence. 00:10:06.000 |
I read this story without giving away that punchline to my kids. 00:10:13.520 |
They're like, Dad, if you say these two names are Ligma Johnson. 00:10:18.960 |
And so, you know, when, when, like, you know, preteens can figure this out, 00:10:27.440 |
Freeberg made the key observation, which is they didn't figure it out because they 00:10:30.160 |
didn't want to because it fit their narrative. 00:10:31.760 |
So they don't fact check things that fit their narrative. 00:10:36.720 |
I just, it was so poignant to me this week when this happened, 00:10:39.520 |
particularly as it relates to Twitter and the importance of call it open journalism 00:10:46.160 |
or citizen journalism and the integrity of kind of, you know, of the voices that we all 00:10:51.040 |
kind of trust as our kind of journalistic authorities that these guys came out and 00:10:55.200 |
they were conned right outside Twitter's offices into telling a story that fit their 00:11:00.480 |
And it was really a kind of poignant moment for me. 00:11:04.160 |
I think it was originally in Rolling Stone and then Rachel Maddow amplified it where 00:11:07.680 |
it was in Oklahoma city where supposedly all these MAGA Republicans were eating horse 00:11:13.760 |
And they were in, this is basically, I thought it was like a COVID therapy. 00:11:16.720 |
And then they were going to the emergency rooms of all the hospitals and then they were 00:11:19.760 |
turning away heart attack victims because there were so many of these people going to 00:11:24.160 |
Anyway, it all turned out to be like a made up story, like a hoax, but the media reported 00:11:31.120 |
It just, it fit too many of their preconceptions to me. 00:11:34.080 |
There's also one, there's another vector sex, which is live coverage is, um, you know, you 00:11:39.920 |
really have to be careful because when doing live people will call in and say, Oh, they're 00:11:45.280 |
And then they will do a baba booey or whatever, you know, kind of charades. 00:11:49.600 |
And so without fact checking and without saying, Hey, we haven't confirmed this yet, but these 00:11:55.280 |
two employees are claiming this people want to get real time coverage. 00:12:00.880 |
I think everybody in the audience has to understand so much credit. 00:12:05.280 |
There was a picture and it said Ligma Johnson. 00:12:22.400 |
There is a different standard for live news coverage. 00:12:24.480 |
And then there we've ripped out fact checking from a lot of these publications and basic 00:12:28.480 |
fact checking and a little bit of time I'm explaining why they make this mistake. 00:12:35.840 |
But they've also ripped out fact checking and then they are in such a race to get the 00:12:43.280 |
If the story fits their priors, they run with it immediately and they don't do any fact 00:12:47.520 |
checking because they don't want to know that it's not true. 00:12:51.680 |
They will check a story if it's a narrative they don't like, because they're gonna make 00:12:55.600 |
they're gonna try and make sure it's not true. 00:12:59.760 |
This thing, there's only one mainstream media. 00:13:09.200 |
The alternative to the mainstream media is the Substack journalists. 00:13:13.920 |
Tell me the writer on Substack who behaves this way. 00:13:20.160 |
What Substack writer got fooled by Ligma Johnson? 00:13:38.480 |
I'm telling you what is happening in journalism today. 00:13:41.120 |
They have ripped out fact checking and they are in a race to beat each other because the 00:13:44.720 |
first person to get the story up gets the clicks. 00:13:48.480 |
They tried to create a story when there was no story there. 00:13:52.560 |
They went out outside of an office mid-market street. 00:13:55.840 |
And they said, hey, there's this sensational thing happening. 00:13:58.560 |
And there was no sensational thing happening. 00:14:00.880 |
And so the little drop that fell into their laps, the little thing that fell into their 00:14:06.720 |
Because that's the story they wanted to see created. 00:14:08.800 |
There was no story beforehand that then that there were all these people being fired, walking 00:14:13.280 |
And then they said, let's go send live TV producers down there. 00:14:19.460 |
They did the same thing in New York at Bear Stearns. 00:14:24.160 |
When they had other major layoffs at Bear Stearns and stuff like that during the financial 00:14:27.920 |
crisis, of course, they sent people to do live coverage. 00:14:31.040 |
I'm just explaining to you what's going on in the background as well with live TV and 00:14:34.640 |
the gutting of newsrooms and having no fact checking. 00:14:38.080 |
But what about the 20 years ago, they used to have a stocky check. 00:14:40.720 |
My 11 year olds and 10 year old the copy editors are better copy editors than these adults 00:14:50.480 |
They were like, Dad, do you understand what you just said? 00:14:56.080 |
This is like prepubescent humor that these people fell for. 00:15:07.760 |
This is a grievance industrial complex, right? 00:15:14.880 |
It's not funny in the case of the 4chan board. 00:15:17.520 |
But these are people who are inventing stories. 00:15:19.600 |
Because there's a certain area to manipulate media because they know it's so easy to manipulate 00:15:29.760 |
Also happens to be a huge fan of the All In podcast, apparently. 00:15:33.360 |
He's welcome on as a bestie guestie anytime he wants. 00:15:37.120 |
All right, we should talk about layoffs and tech lift 13% 00:15:45.600 |
Stripe 14% riff 1000 employees open door chime, 00:15:49.440 |
Dapper Labs, all hundreds of employees open door the most significant there 550 18% 00:15:59.120 |
We'll see what the riff winds up being but that's occurring as we're taping here. 00:16:11.200 |
Yeah, maybe trying maybe signaling a pause but haven't they've been hiring like in absolutely 00:16:17.600 |
and in crazy crazy pace and we'll pull up the chart here actually. 00:16:20.880 |
It's instructive to look at Facebook and Google because they have not slowed down 00:16:29.920 |
This all started to peak in June and now is starting up again. 00:16:33.680 |
So there's a website layoffs dot fyi that's been tracking all these layoffs you can see 00:16:39.520 |
the number of layoffs these are kind of major layoffs and the number of employees impacted 00:16:43.680 |
been pretty consistent in the third quarter, it started to die down in September. 00:16:50.080 |
From the peak in May and June, and now this is gonna be picking up right? 00:16:56.080 |
Yeah, it feels like this is the double dip we were talking about. 00:17:01.600 |
Well, I think that we had if you take a very balanced view of what happened this week. 00:17:06.720 |
You have to start, I think, with the Federal Reserve and really what they said is rates 00:17:11.680 |
will probably be higher than all of you think and they'll be higher for longer than all of you want. 00:17:17.360 |
And again, without debating whether, you know, that's gonna come to pass or not. 00:17:24.000 |
The thing that you can do is you can build a little sensitivity model to understand the 00:17:31.760 |
And basically what it means is that the dollar that's right in front of you. 00:17:36.560 |
Is now meaningfully more important than the dollar that's far, far away from you. 00:17:41.360 |
That you know the Fed funds rate goes to five and a half percent or so. 00:17:46.480 |
Even five let's go to the optimists and say it's only going to go to five. 00:17:51.200 |
Tech companies have to achieve 500 basis points above that minimum. 00:17:55.520 |
So we all have to generate 10 to 11 percent returns for us to be on a risk adjusted basis. 00:18:05.120 |
The problem with that is all of a sudden, you know, if you're trying to generate cash, 00:18:14.800 |
And so, you know, they are really reprioritizing the value of short-term profits. 00:18:20.240 |
And that's going to affect how companies get money. 00:18:27.680 |
So I think this is what companies are now bearing down for. 00:18:31.520 |
They're realizing, oh, man, I need to get my cost structure way in line. 00:18:35.600 |
It is way better now just to think about this contrast. 00:18:39.440 |
It's way better to grow at 20 percent and be profitable. 00:18:42.320 |
Then it is to grow at 100 percent and burn money because it's not clear where that 00:18:47.280 |
second company is going to get the incremental dollars they need for growth. 00:18:50.320 |
And that's just a mathematical realization when rates are five percent. 00:18:55.280 |
So this is this is that moment where you see that pivot from pivot growth to profit. 00:19:02.080 |
We've been talking about it for six months, but this is this is this is how it is manifest in 00:19:07.280 |
Silicon Valley companies is of scale is through layoffs and cost reductions and cost savings. 00:19:13.600 |
So the investments in future growth are reduced and the timeline to drive greater profits 00:19:23.360 |
I think if what Elon is going to do a Twitter or what is reported. 00:19:28.240 |
So this is nothing to do with anything anyone told me, just what I've read in the reporting 00:19:32.240 |
is accurate that he's going to cut so deep he's going to cut 30, 40, 50 percent potentially of 00:19:38.400 |
It really sets a new standard for how profitable a tech company can get. 00:19:44.480 |
And again, I'll give credit to a Twitter poster named Postmarket, who I didn't give credit to a 00:19:48.880 |
few weeks ago when I read this tweet, which I think was a good one, which was that Elon's 00:19:55.040 |
really going to show everyone just how profitable these tech companies can be, just how lean they 00:20:00.000 |
And, you know, when you're doing a 10 percent riff or a 13 percent riff, you may or may not 00:20:06.240 |
even be getting to profitability with that riff when you cut 30, 40, 50 percent deep and you 00:20:12.160 |
can actually turn a real profit on a business, an enterprise scale business like a Twitter or 00:20:17.040 |
like many other enterprise software companies that are out there right now. 00:20:19.840 |
It really kind of sets a new standard that a lot of folks might then end up saying, you know 00:20:26.000 |
And there could be the case that private equity firms take a look at this. 00:20:29.600 |
And there's a lot of these distressed mid cap and small cap software companies out there 00:20:33.760 |
that private equity firms now realize, wow, you don't actually need 50 percent of the 00:20:39.440 |
workforce in order to keep the product running and to drive to profitability. 00:20:43.440 |
And you could see a bit of a flurry of buyout activity as more folks come in and maybe try 00:20:51.120 |
So, you know, that's one kind of prediction I think may arise if Elon is successful in 00:20:56.000 |
making Twitter a much more profitable enterprise. 00:20:59.200 |
It could set a new model that catalyzes a lot of other M&A activity, a lot of other 00:21:03.440 |
buyout activity of these distressed small and mid cap companies by by other actors. 00:21:10.000 |
Nick, could you please just throw up that tweet that I sent just for all of these guys 00:21:16.000 |
So to your point, this is an incredible slide. 00:21:19.840 |
And essentially what it shows for those folks that are not watching this on YouTube is it 00:21:24.880 |
essentially shows the private software universe and then the public software universe at different 00:21:32.800 |
So as an example, right now there are 15 companies, private companies that are valued greater 00:21:39.120 |
than 10 billion dollars, and there are 40 public ones that are valued greater than 10 00:21:44.880 |
There are 50 companies between, you know, more than 5 billion, but only 60 that are 00:21:54.960 |
There are 400 companies who have an average valuation of 3 billion. 00:22:00.800 |
And then there are already 70 companies in the public markets where they have a billion 00:22:09.840 |
And it just goes to show you to your point, Freiburg, if these folks have to generate 00:22:15.680 |
an 11% hurdle rate, their cost of capital is 11%. 00:22:19.840 |
The companies on the left will have to go through a lot of very difficult cost cutting, 00:22:26.800 |
potentially headcount reductions, you know, repricing of the product, all kinds of things. 00:22:40.000 |
There's almost 500 companies here that have to do an enormous amount of work so that they 00:22:45.760 |
have a chance to be on the right hand side of this chart. 00:22:47.840 |
The point is that you didn't have to do this when rates were zero. 00:22:51.840 |
There was just an abundance of free money and risk seeking and duration that is now 00:22:58.560 |
Jamal, I think there's also a story that of the 200 companies that are software, public 00:23:03.120 |
software companies that you see on the right, some number of them will need to go private 00:23:07.600 |
in order to do the restructuring that the market is demanding that they do in order 00:23:12.800 |
And to your point, it will happen at meaningfully lower valuations than where they probably 00:23:17.360 |
went public or their last round, which will put you guys as you guys enormous pressure. 00:23:22.480 |
Yeah, if you guys look at these 200 companies on the right, how many of them do you think 00:23:25.520 |
go private over the next 18 months to get restructured? 00:23:29.360 |
Allah, what you want is everyone is possible Twitter. 00:23:35.200 |
But to your point, freeberg, I think if you look at the number of them that are unprofitable, 00:23:43.200 |
And about so I think about two thirds of these companies really have no line of sight to 00:23:47.600 |
profitability in the next two to three years. 00:23:49.840 |
And again, if you if you layer in this cost of capital argument, all of those companies, 00:23:55.280 |
David will have to raise money at very egregious terms in order to keep themselves going as 00:24:03.120 |
a public business, in which case their alternative is to go private in a PE transaction. 00:24:08.720 |
So it's probably at least half these businesses. 00:24:16.800 |
Because you know, these businesses and the models, I mean, some of them, it's hard to 00:24:20.720 |
get profitable if you're scaling SAS business, right? 00:24:22.880 |
Like, you have to get to a certain scale before it's possible. 00:24:25.920 |
Well, I don't, I don't, that's like a very specific question of like, how many of them 00:24:30.240 |
are going to get acquired by PE firms versus going public or going private after being 00:24:37.840 |
I think the larger point is just that it feels to me like the economy is headed off a cliff 00:24:42.880 |
I mean, I can tell you within our larger portfolio of companies, like I can see the trajectory. 00:24:49.600 |
So after Q1 board meetings, I would say about two thirds of portfolio companies were hitting 00:24:57.680 |
And it still appeared to be like problems related to those specific companies, not a 00:25:03.360 |
I would say after Q2 board meetings, two thirds were missing and one third were hitting their 00:25:08.240 |
And you could start to feel, okay, maybe there's like a macro trend here. 00:25:11.680 |
And I would say after Q3 board meetings, like now, the entire portfolio is reforecasting. 00:25:19.200 |
Maybe there's like a handful of companies here or there that aren't, if you're one of 00:25:23.840 |
But like even the best companies in our portfolio now are seeing major headwinds. 00:25:28.080 |
And this is just, I think, an economy-wide slowdown. 00:25:35.520 |
Let me just ask, in the public markets, do you think those public companies can get restructured 00:25:39.760 |
as public companies in order to make these profits? 00:25:51.200 |
Like look, take Coinbase versus Carvana, right? 00:25:54.320 |
These are both businesses that issued convertible debt sort of right before things got very, 00:26:01.760 |
And if you look at where their convertible debt trades, it's trading basically at an 00:26:05.840 |
implied yield of about 12 or 13%, both companies. 00:26:08.960 |
Now, one is probably a legitimate bankruptcy risk, which is Carvana. 00:26:15.840 |
Whereas the other one, I think it has a very fortified balance sheet and could weather 00:26:21.280 |
But unfortunately, in a moment where rates are, again, the risk-free rate goes to five, 00:26:27.440 |
five and a half, our cost of capital to do business goes to 10 or 11, these guys have 00:26:33.760 |
My gosh, it's really, really dilutive to be in business right now. 00:26:38.720 |
So it just goes to show you that you can stay public. 00:26:42.560 |
But if you want to get incremental money to cover your burn, the only way you can do it 00:26:47.440 |
without really, you know, blowing up your cap table and doing a massive recap will be 00:26:54.320 |
But it has a huge overhang and you risk turning the keys over to the debt holders of the company. 00:27:00.320 |
So the alternative for that business is to go into the hands of private equity and get 00:27:07.120 |
out of the spotlight of these public markets. 00:27:13.520 |
And the thing that's happened to them is they can't raise debt. 00:27:17.520 |
So what do you think they do, they just have to pay 50% less than what they would be willing 00:27:20.960 |
to pay before because they have to write, you know, 100% equity check. 00:27:24.560 |
So there is no free lunch anymore, I think is the big is the big point to point out anywhere 00:27:32.240 |
I think one of the things I'm most concerned about or would be is I was talking with a 00:27:36.400 |
friend who works at a private, you know, unicorn software company. 00:27:41.040 |
And he we talked about the numbers of the business. 00:27:44.160 |
And I was like, Oh, that company is probably worth x. 00:27:47.280 |
And then I asked him how much money they've raised, and they've raised more than x. 00:27:50.000 |
So I was like, dude, your options are worthless. 00:27:53.440 |
Like, you know, this is a real problem, I think that's probably going to become very 00:27:56.880 |
systemic for scaled unicorn software companies, what happens to these businesses sacks in 00:28:02.560 |
the market, you know, as they kind of need another round, but the value of the company 00:28:07.920 |
is now less than the total cash that they've raised that all is sitting as preferred stock. 00:28:11.360 |
Listen, it's survival of the quickest, those who are most willing to adapt the most quickly 00:28:18.640 |
are going to survive and the ones that are stubborn and refuse to accept the new regime, 00:28:24.560 |
We showed that chart, remember that chart from Sequoia months ago, on this podcast, 00:28:29.440 |
remember that where it basically showed what happens if you're a company that doesn't cut 00:28:34.560 |
burn until the very end, then you're still gonna run out of money and die. 00:28:37.680 |
But if you make the cut right away, quickly, you have enough runway to weather the storm. 00:28:43.120 |
And I think that what we've seen is, you know, at my firm craft, yeah, this is exactly it. 00:28:48.640 |
Yeah, we showed this months ago, we've been begging our founders to embrace this. 00:28:52.560 |
We did a portfolio, a review with our entire set of founders of our portfolio companies, 00:28:58.800 |
we did one in February, when we felt the markets were changing. 00:29:01.920 |
And we did another one in May, and we showed the slide. 00:29:04.960 |
And this is the most important thing for founders to internalize, is you have to make 00:29:10.400 |
You know, one way for them to think about it is, let's say you're a unicorn company, okay? 00:29:14.240 |
And you raised at the peak, let's say second half of 2021, you raised $100 million at a billion 00:29:20.800 |
And let's say you've got 50 million left in the bank, right? 00:29:25.200 |
A lot of these founders are thinking that 50 million they've got left is only 5% dilution. 00:29:31.280 |
If you were to raise a new round today, you might only be valued at 250. 00:29:35.280 |
So that 50 million you have left is actually 20% dilution. 00:29:39.200 |
And that's if you could even raise, which might be very, very hard. 00:29:42.560 |
The most important thing founders can do is forget about the historical terms on which 00:29:49.040 |
Forget about how much money you were burning in the past. 00:29:51.360 |
Just think about how much money you have in the bank today. 00:29:54.240 |
Impute a valuation to it, so you really internalize how much dilution that money represents, and 00:30:00.640 |
then create a new plan moving forward to preserve that cash as long as possible. 00:30:04.880 |
Can I say something else quickly on top of this? 00:30:08.560 |
The thing that again, people should do is you should just build a little spreadsheet 00:30:15.040 |
for yourself to understand what the alternative financing options are for people who are in 00:30:22.400 |
So David, to your point, the current three month T-bill rate is 4%. 00:30:27.280 |
You can buy munis now between 4% and 5% that are triple tax advantaged. 00:30:32.240 |
You can buy high quality corporate bonds that are 6%, 7%, 8%. 00:30:38.640 |
You can buy stocks that have a dividend yield of 5% of growing market leading companies. 00:30:47.280 |
And so all of a sudden, like turning around and giving it to a company where there is 00:30:50.720 |
no end in sight in terms of it doesn't get you to profitability is a really, really hard 00:30:57.200 |
I was talking to an entrepreneur, David Soloff, just yesterday, and he said it really well. 00:31:03.360 |
He's like, listen, you know, I'm not a macro economist. 00:31:06.560 |
I'm not trying to forecast, but he's like what I understood yesterday. 00:31:10.480 |
This is David talking about the Fed as an entrepreneur. 00:31:16.160 |
The Fed has said this is not going to be some triangle sawtooth. 00:31:20.080 |
It's not going to go up sharply and then come back down sharply, which is what we would 00:31:24.960 |
all want if we wanted things to get back to normal sooner. 00:31:29.360 |
The angle of attack is now a little bit slower, which means it's going to take longer to get 00:31:35.360 |
And then we're going to stay there for a lot longer than we want. 00:31:38.560 |
And when you roll those two things together, a lot of companies may run out of money. 00:31:43.360 |
And so if you can't get to default alive, you have to look at your cost structure and 00:31:49.040 |
figure out how to right size this thing, because the cost of capital is just going to be really, 00:31:56.480 |
They want to take away this free capital, they want to slow the economy down. 00:32:05.440 |
But we're adding jobs to the economy, we have more job openings, and we had 2.6% GDP growth. 00:32:11.920 |
So I guess my question to the everybody here is, what is the Fed going to have to do? 00:32:18.000 |
Or can they stop this consumer and this growth? 00:32:23.680 |
Paolo Paolo said, he'd rather overcorrect and break things because he has a toolbox to fix 00:32:31.760 |
But he doesn't have a toolbox to fix if they under correct, and they have rampant inflation. 00:32:36.880 |
I mean, not more explicit, you can't get Jason, so he's going to take rates until demand is 00:32:43.360 |
destroyed, and enough demand is destroyed, such that inflation is tamed. 00:32:48.320 |
But that has huge implications to all of us, because we all have to do our job, trying to 00:32:52.880 |
build a company, trying to raise money, trying to invest money. 00:32:55.920 |
It's just getting much, much, much harder than I even thought. 00:33:00.640 |
So like, you know, for me, I'm like, wow, I thought that we could get through the worst 00:33:06.400 |
But now you have to plan for the worst, which means, okay, now I'm thinking that men rates 00:33:11.200 |
could be higher for much longer, which means, you know, we could be in this market till 00:33:17.280 |
And you may say, hey, that's way too conservative. 00:33:20.480 |
Yeah, but you have to plan for conservatism in this point. 00:33:25.280 |
Honestly, I'm like, I should just put more into T bills. 00:33:30.400 |
If a company's like H math can have another 10 15 20 million bucks? 00:33:33.280 |
I'm like, wow, I mean, I don't think that that gets you anywhere. 00:33:36.960 |
And oh, by the way, that 10 or $20 million, I can generate 4%. 00:33:42.880 |
For Well, for somebody who has access to private markets, which should be high growth companies 00:33:47.360 |
to take the guaranteed for over the 50 x 25 x 10 x, whatever we're trying to bet on here. 00:33:53.680 |
Yeah, it's not just the guaranteed for but if you want to take tech risk, then you could 00:33:58.080 |
go buy the corporate bonds of some high quality companies for the 10 or 11%. 00:34:03.280 |
So you're also competing with that not to zero risk. 00:34:05.200 |
Can you explain that for the listeners what that corporate debt is and why it, you know, 00:34:09.280 |
There are there are, you know, high quality public companies, tech companies that have 00:34:15.760 |
And they obviously have to pay a higher rate than what the Treasury pays, because the Treasury 00:34:25.600 |
But, you know, it's like, if you're willing to take tech risk, then why wouldn't you buy 00:34:30.560 |
Meaning the equity always has to beat that threshold return. 00:34:34.080 |
But But hey, can we just go back to the jobs report for a second? 00:34:37.920 |
I mean, the US government could default, but it's considered the least likely to default 00:34:44.400 |
And that's why I said, yeah, that's why people call it the risk free rate, because it is 00:34:51.440 |
the US can always repay its debt, because the debt is denominated in dollars, and the 00:34:56.000 |
Treasury can always at the end of the day, print more money that would just be monetizing 00:35:00.080 |
Other countries that owe money in dollars, and obviously don't control the US Mint, they 00:35:07.520 |
But since we're the world's reserve currency, we're never going to default. 00:35:10.640 |
However, the dollars that you get paid back by the US government might be worth a lot 00:35:17.200 |
And that's the real risk you have to think about. 00:35:23.280 |
But let's go back to this, the jobs picture for a second. 00:35:28.240 |
So there is news this morning that we added 261,000 jobs in October. 00:35:32.400 |
And obviously, given that there's an election in a few days, then the administration is 00:35:38.240 |
But if you dig a little deeper in the report, I just posted the link there, you see in the 00:35:42.640 |
raw numbers that there's actually 328,000 fewer employed Americans. 00:35:48.000 |
And the number of unemployed Americans actually increased to 36,000. 00:35:52.400 |
And the labor force participation rate declined for the third consecutive month to 62.2%. 00:35:59.440 |
So I don't really understand how all these numbers add up. 00:36:05.600 |
And there's definitely a negativity in there. 00:36:08.800 |
And this feels to me like the last gasp of the bull market where there's this residual 00:36:17.120 |
But you look at just what's happened in the last week, where it's stripe cutting. 00:36:21.200 |
I mean, stripe's probably the single highest quality, I think it's probably the most valuable 00:36:29.840 |
But like software, pure software company, they had a 14% cut, you're starting to see 00:36:36.560 |
So I think we're at the beginning now of a long cycle of the unemployment rate going 00:36:42.160 |
I mean, it just feels like the economy is slowing so fast. 00:36:45.840 |
The markets are, you know, they've been puking now for six months. 00:36:50.560 |
It just feels like this is the beginning of a like really serious recession. 00:36:54.080 |
Yet we had GDP growth, yet we had job openings. 00:36:58.240 |
No, remember we had two quarters of net negative GDP growth. 00:37:02.320 |
This is when we had the debate about what a recession is. 00:37:04.640 |
It was true that if you looked at growth in nominal terms, it appeared to be strong, and 00:37:09.440 |
then it was net negative once you subtracted the inflation rate. 00:37:12.640 |
You know, we said several months ago, my prediction was a double-dip recession where you had this 00:37:17.600 |
shallow technical recession, then it bounced back in Q3. 00:37:20.400 |
But now I think we're headed into the second part of it, which is the real recession, a 00:37:26.720 |
And you're starting to see economists say we're going to go from 3. 00:37:29.600 |
Something percent unemployment rate to say five or 6% unemployment next year. 00:37:34.000 |
So I think we're just beginning to see the job cuts start to add up. 00:37:38.480 |
This is, I think this is what Powell meant, which is, you know, he'll take it as far as 00:37:44.160 |
it takes, and then he can fix it on the back end by reintroducing, you know, quantitative 00:37:50.000 |
easing and reintroducing lower interest rates to stimulate demand. 00:37:55.600 |
But there is one of the odds he gets this right. 00:37:57.760 |
It seems to me that the Fed has a habit of reacting too slowly. 00:38:04.480 |
My guess is that they'll be too slow to react to the recession. 00:38:08.240 |
So we'll end up with a period of rates being higher than they should too long, and then 00:38:12.480 |
they will correct, they'll drop rates, but that could be two years from now. 00:38:16.320 |
And meanwhile, we could be in a pretty deep recession. 00:38:18.720 |
Here are the two charts for you to look at the GDP by quarter. 00:38:22.960 |
And then after that, the labor participation rate. 00:38:25.760 |
So there's your GDP, q1 q2 being negative q3 bouncing back, we'll see what happens in 00:38:31.200 |
Here's your Fed force participation rate for labor, as we discussed, 00:38:35.600 |
the thing with the labor participation rate that we're still not sort of like truly factoring 00:38:39.440 |
in is like, you know, we had a million Americans die because of COVID. 00:38:42.880 |
And, you know, starting in that Trump presidency, we lost like seven or 8 million immigrants. 00:38:48.080 |
So those 8 million people have a huge effect on this number. 00:38:54.560 |
Because if, if, if you see that at the start of the Trump presidency, it's just it just 00:39:00.160 |
And you also have people who retired early, that was a big trend. 00:39:05.920 |
Labor participation hit that like 67 68%, I think is the peak. 00:39:09.920 |
And just slowly going down as boomers retire early, because they made so much on their 00:39:16.320 |
And then you're right, trim off, we've had negative, we've really cut immigration the 00:39:21.600 |
last whatever, five, six years, I think there's an element in here that's missing on how much 00:39:26.800 |
people individually are finding other ways to earn income that doesn't qualify and show 00:39:33.440 |
People have set up Etsy stores, Shopify stores have tripled since COVID. 00:39:39.520 |
People are making more money on YouTube on Instagram on Tick Tock than ever before. 00:39:45.600 |
There's a whole new class of work that revolves around the individual, creating their own 00:39:52.160 |
business creating their own income stream that simply taken off and has taken off. 00:40:01.760 |
And there's an element of this that's really more about the transition of how people work 00:40:08.400 |
I don't think that the idea that everyone should go be an employee at a company is necessarily 00:40:12.720 |
the right way to think about labor going forward. 00:40:15.040 |
The amount of money that individuals are earning is probably the better way to frame this up 00:40:19.680 |
going forward and really thinking about the earning power and the economic health of this 00:40:24.320 |
This is something important you're bringing up here. 00:40:30.880 |
And Uber and Dara had they grew over 70% this year. 00:40:35.680 |
But I think the big number that I watched for was drivers are making $36 an hour in 00:40:43.360 |
People are finding other options, whether it's DoorDash, Uber, and that doesn't qualify 00:40:55.600 |
If somebody wants to fact check us, that'd be great. 00:40:57.600 |
But my understanding is independent contractors, which is what gig workers are classified under 00:41:09.120 |
There was a story in BBC that the Bank of England has now warned that the UK is facing 00:41:21.620 |
But look, here's what I think is scary about going into a recession is number one, you 00:41:25.760 |
don't really know how long it's going to take to get out. 00:41:27.760 |
We know the average recession lasts about 18 months. 00:41:29.840 |
But the truth is once it starts, you just don't know. 00:41:32.080 |
And the second thing is you don't really know who's been stress tested. 00:41:35.280 |
People claim that they can weather the storm. 00:41:38.160 |
But the truth is that there's no way to simulate, truly simulate a stress test. 00:41:44.560 |
But the only way is to really subject an institution to that pressure and that stress. 00:41:49.840 |
And then you see if they come out the other side. 00:41:52.400 |
So that's the issue is you're just going into this. 00:41:57.600 |
And this is why I would just urge founders to be cautious is because if the recession 00:42:03.680 |
ends up being shallower and shorter than people expect, great. 00:42:08.960 |
But if the recession ends up being deeper and longer than expected, you don't want to 00:42:15.680 |
So again, we've been saying this since February and May. 00:42:19.120 |
But again, I just reiterate, I think it really makes sense for founders to be conservative, 00:42:28.000 |
This recession probably will last about two years. 00:42:32.640 |
And to Shama's point, if you survive it with lower growth, that's fine. 00:42:35.840 |
You can keep growing on the other end of this thing. 00:42:37.920 |
But if you go out of business, because you grew too fast, then you're not going to get 00:42:41.920 |
the chance to fix that problem when the recession is over. 00:42:44.560 |
I just don't see anybody rewarding hyper growth that is burning a ton of cash where you have 00:42:52.720 |
Because it's just very hard to feel comfortable that the conditions on the field aren't going 00:42:59.680 |
to be drastically different a year from now, right? 00:43:02.400 |
It's not like we know that it's going to be better or worse. 00:43:06.080 |
And I think that that uncertainty is actually really bad for companies. 00:43:09.440 |
So to your point, it's just like a lot of folks have tried to shy away, David, from 00:43:17.200 |
They've done these complicated converts, and they've tried to basically, you know, 00:43:21.680 |
it's I think it's sort of like managing their ego or the board's ego. 00:43:27.280 |
And I think like the next shoe to drop has to be these founders and these boards just 00:43:32.800 |
saying, OK, let's just take the hard medicine. 00:43:34.640 |
What's the real market clearing price and valuation? 00:43:38.800 |
And let's get new fresh equity and then move forward. 00:43:41.840 |
Because if you don't do that, and you wait until everybody's trying to do it, then it's 00:43:48.160 |
So better to your point, you know, this is why like Stripe, it's so smart, better to 00:43:56.880 |
But it's better to do that now than 18 months from now. 00:44:00.240 |
Because you just have no idea how much more expensive or hard it's going to be then. 00:44:04.960 |
And who's going to even be in the business of lending money or investing money in 18 00:44:12.480 |
But it's like, I think that that's, that's the moment that we're in to your point, 00:44:18.080 |
And according to the Fed of St. Louis, if you counted casual workers, informal workers, 00:44:27.440 |
over doing over 20 hours a week of informal work, aka gig work, you would increase labor 00:44:34.560 |
participation between a half point and a point if you counted all of them, maybe even slightly 00:44:41.200 |
So probably about a point seems like a realistic way to look at labor participation. 00:44:46.000 |
And of the eight points, or maybe now the six or seven points to 10%, it would then 00:44:52.000 |
account for 10 to 20% of the 10% drop in labor participation. 00:44:56.560 |
It's just alarming statistics, because if most people have most of their personal net 00:45:02.880 |
worth tied up in their home asset, and their home values are declining, or going to decline. 00:45:07.280 |
And we're seeing this dramatic spike in consumer credit in the US, it paints a really ugly 00:45:16.000 |
Wow, guys, I'm just looking at I'm just looking at the markets today, get labs down 15% snowflakes 00:45:35.760 |
Oh my gosh, the cloud computing index, WCLD has hit a new low for the year, it's down to 00:45:42.560 |
23 bucks, I think the previous low was 25 is down almost 8% today. 00:45:46.400 |
And this is on a day in which the NASDAQ is down less than 1%. 00:45:54.640 |
And so, listen, if you're a startup founder, you got to realize these are like some of 00:46:06.420 |
But guys, this is this is just math, you know, it's not a judgment on any of these companies, 00:46:13.680 |
This is why I think you have to be utterly unemotional in this moment. 00:46:17.360 |
And if you're if you're a CEO, running a company, particularly a SaaS business, 00:46:24.880 |
how to right size your cost basis and make this money last profitable industrial companies are 00:46:31.280 |
Bill Gurley had a tweet a tweet about this a few months ago about how the biggest mistake 00:46:35.760 |
people make in riffs is they just do like a tepid riff, like a 10% ish riff, and they have 00:46:43.360 |
This is what I think the the Elon action this week really sets a standard, he shows the 00:46:48.160 |
entirety of Silicon Valley, that you can cut deep and you can turn a profit and you can do it fast. 00:46:53.440 |
And it could set a new standard for how folks are managing this jack Welch used to in his 00:46:57.680 |
management principles, recommend dropping the bottom 10% of people every year. 00:47:02.160 |
And so, you know, the 10 13% cuts don't really pass muster as a public market investor kind 00:47:07.840 |
of looks at the the management across these different companies to turn a profit, they're 00:47:12.240 |
going to say the folks that are making the deepest cuts, the fastest are the ones that 00:47:16.080 |
It's unfortunate, and it's a difficult circumstance for everyone in Silicon Valley to deal with 00:47:20.480 |
from the employees, to the investors to the public and private shareholders. 00:47:26.080 |
It's really just this kind of market motivation that's underway right now. 00:47:31.040 |
And my question for you is when do Google and Facebook stop this? 00:47:35.520 |
I mean, if you look at the number of employees being added, it is truly extraordinary. 00:47:49.440 |
Hold on, didn't they announce a hiring freeze? 00:47:51.360 |
They announced that they were at Google, they announced that they were going to hold people 00:47:56.480 |
accountable to better performance, and they were going to go do more with less. 00:48:09.600 |
You look at Apple, Apple just announced in non-R&D functions a hiring freeze. 00:48:14.160 |
This is Apple, like the most valuable, most profitable company in the world. 00:48:17.920 |
So if Apple basically is putting the brakes on non-engineering hiring, that tells you 00:48:23.840 |
something about how fast the economy is slowing down. 00:48:28.160 |
The point Freeber makes is, you know, I think it's a good thing that Apple is doing this. 00:48:32.160 |
The point Freeber makes is so correct, which is, if you're doing a RIF, obviously there's 00:48:37.120 |
a reason why, but I think we're seeing too many RIFs where the details of the RIF and 00:48:42.720 |
the magnitude of the RIF don't match up with what the objective of the RIF is. 00:48:46.720 |
The objective of the RIF for a lot of these companies should be to get them cash flow 00:48:51.840 |
positive, or at least to put them on a runway or trajectory where they can get cash flow 00:48:57.760 |
positive with their existing cash on the balance sheet, right? 00:49:02.080 |
And we're seeing a lot of companies where they don't achieve that, and they have to 00:49:09.200 |
And that creates more turmoil for the company, and it's more unfair for the employees. 00:49:14.320 |
By the way, Sax, to that point, I'll just say how deep these companies are cutting and 00:49:18.720 |
how quickly management is expressing to their shareholders how they're going to turn a profit 00:49:24.080 |
becomes a signal for those shareholders on whether or not they want to stay in that stock. 00:49:28.080 |
And the companies that are doing it fast and are doing it deep, the investors and the shareholders 00:49:32.480 |
say you do actually have a path that makes sense here, I'm going to stay in the stock 00:49:37.600 |
Charles, let me ask you a question in terms of strategy for one of these companies, let's 00:49:41.280 |
say the Facebook Corporation, or perhaps even Google, or Apple, even if they were to cut 00:49:48.720 |
their expenses, which might take obviously a RIF. 00:49:51.680 |
And then because their stock prices are so depressed right now, maybe even a mid cap 00:49:56.400 |
one like a Twilio or an Uber or an Airbnb, they were cut costs and then start buying 00:50:01.520 |
back their shares, which some companies have been doing. 00:50:04.400 |
What would that do in terms of the markets appreciation of those stocks or management 00:50:09.600 |
I think that the if you have not lost investor trust, I think it would be really well rewarded. 00:50:18.960 |
If you have become unreliable and undisciplined, even those cuts, I think would be met with 00:50:27.920 |
some amount of excitement, but probably not a broad based support. 00:50:33.280 |
So, you know, it then it just goes to narrative, meaning if Google did it, I think that people 00:50:44.720 |
They would they would probably move very quickly into the echelon of Apple and Apple is sort 00:50:50.240 |
of a first among equals like they're just they're just in a different class unto themselves. 00:50:55.360 |
Facebook, I think is a little bit harder because I think folks have gotten burned and, you 00:51:01.040 |
know, they would have to make some really, really deep cuts. 00:51:07.680 |
But then the other part is where you make all the money. 00:51:10.400 |
And so you have this huge morale issue that you have to manage. 00:51:17.040 |
Just one more thought on on on the RIF stuff. 00:51:20.560 |
I think one thought experiment for founders is to think about what was your plan at the 00:51:28.240 |
Because 2020 and 2021 were two of the most distorted years ever in the history of financial 00:51:34.000 |
markets and the economy because we had COVID and then we had the reaction to COVID. 00:51:38.720 |
And so you saw there was this, you know, Zoom's market cap hit 100 billion, all the 00:51:43.600 |
e-commerce companies were doing extremely well. 00:51:45.840 |
You know, you had all this money printing, you know, you had zero interest rates and 00:51:50.960 |
You had SaaS companies hitting all-time highs at the end of 2021. 00:51:54.400 |
So we lived through this incredibly distorted time. 00:51:57.040 |
So as a thought experiment, go look at what your plan for 2020 was supposed to be when 00:52:05.040 |
Because that was the last time that you were thinking without any distortions, you know, 00:52:11.200 |
And I think if you were to go back and look at your 2020 plan, again, created at the end 00:52:16.320 |
of 2019, you'd probably see that you could get by with half the headcount you have now 00:52:21.600 |
because probably you doubled your headcount during the last two years during these heady, 00:52:26.560 |
And yet I think founders start thinking, "Oh, I can't go back to operating, you know, 00:52:30.480 |
I can't operate at half the level of headcount." 00:52:32.880 |
But you were, you were operating with half the level of headcount by definition at some 00:52:38.560 |
I also think sometimes I think what founders say is, "What will people think if I cut 50%?" 00:52:43.200 |
Meaning all of a sudden the perceived success of my business would be different. 00:52:47.680 |
And I think that this is where you have to realize, no, like there's a lot of ego tied 00:52:52.480 |
up in these things, which slows people down from doing the thing that they need to do. 00:53:02.160 |
I mean, they did this ginormous riff during COVID because they had no choice. 00:53:07.040 |
I mean, their revenue went essentially to zero. 00:53:12.640 |
It's throwing off massive amounts of free cash flow. 00:53:14.960 |
And the stock market seems to really love what Airbnb has done. 00:53:17.760 |
And a similar story over at Uber in terms of having done significant riffs and probably 00:53:25.760 |
Airbnb is still down almost 75% off its high. 00:53:31.200 |
So they're up today 3%, so meaning they're not down 30% in one day, but they have gone 00:53:37.920 |
They have gone down with the rest of the market. 00:53:39.920 |
But it feels like the business I'm talking about the business fundamentals when you're 00:53:43.840 |
throwing off almost a billion dollars of free cash flow. 00:53:46.400 |
Yeah, now you're going to start people are going to perceive that business maybe as 00:53:52.320 |
Or same thing with Uber throwing off free cash flow. 00:53:54.320 |
Now, I think a lot of these names are going to I don't own Airbnb right now, but I do 00:53:58.640 |
I think the people throwing off the free cash flow are going to look pretty attractive 00:54:04.240 |
All right, everybody, let's talk about the midterms. 00:54:06.720 |
A lot of big Senate races and obviously governors, Pennsylvania, Georgia, Arizona, Wisconsin, 00:54:19.120 |
Well, it looks to me like there's gonna be a republican wave, there was an interesting 00:54:24.480 |
article actually on CNN, where they it's called five scary numbers for Democrats. 00:54:28.960 |
And what they point to is that Biden right now has a 42% approval rating. 00:54:37.360 |
61% of the American people say he hasn't focused on the key problems. 00:54:43.200 |
51% say the economy is no issue compared to only 15% for abortion. 00:54:49.200 |
I don't think I've seen a right track wrong track index that was so negative. 00:54:53.440 |
And 75% of the country says we're in a recession. 00:54:57.360 |
So you know, when you look at polling numbers like that, it must translate, I think, into 00:55:02.240 |
a republican wave and you have now real clear politics currently has the GOP gaining four 00:55:08.720 |
So winning in Arizona, Nevada, Georgia, and New Hampshire, that's a big change from just 00:55:13.680 |
a couple weeks ago, and winning 31 house seats. 00:55:16.480 |
So this is this is kind of what it's looking like right now. 00:55:19.920 |
But look, the margin is still within the within the margin of error on the polling. 00:55:25.760 |
So Nate Silver's pointed out that within one standard deviation, you could either have 00:55:31.200 |
a republican wave or you could have basically the republicans fizzle out. 00:55:37.440 |
But ultimately, I think this breaks republican. 00:55:40.880 |
Yeah, the to me, the way that I've I'm looking at it right now is that it seems like most 00:55:47.520 |
scenarios, the republicans will have the majority in the house. 00:55:50.560 |
And the real question is what happens in the Senate. 00:55:55.840 |
And that's going to be really interesting to see. 00:55:59.280 |
So, you know, things where I thought would break republican in the Senate, like Pennsylvania 00:56:04.560 |
are now back to almost the, you know, a statistical dead heat. 00:56:07.440 |
So it's a really interesting moment, actually, it's, but most scenarios, David, I think you'd 00:56:17.200 |
And then there's a non there's a plurality of scenarios where they also in the Senate, 00:56:20.880 |
the house will almost certainly go republican. 00:56:23.120 |
But I think the Senate now the official percentages are 55% likely to tip republican. 00:56:28.160 |
But I just think that in a wave year like this, where the wrong track sentiment is so 00:56:33.920 |
high, I think all these races that are a dead heat, they're more likely to break in one 00:56:38.880 |
direction as opposed to like a random distribution, which is why I think you could just as easily 00:56:43.840 |
end up with an, you know, instead of it being a 51 49 Senate, it could be 5545. 00:56:51.440 |
Because all these things could break the same way. 00:56:53.040 |
So right now, so I would slightly disagree in Pennsylvania, I think Oz has improved as 00:57:00.240 |
And since he suffered that stroke, he kind of came across as somebody 00:57:04.640 |
That I, I had very, very hard to watch that happen. 00:57:09.760 |
I mean, the guy, the guy has suffered a stroke and is sad, but he you know, he doesn't 00:57:13.760 |
present as someone who can be a senator right now. 00:57:18.880 |
Like, are we as a society, is this a good idea to have somebody post stroke be in office? 00:57:26.560 |
Oz is actually doing the right thing right now, which is he's not actually focusing on 00:57:29.920 |
that issue, because it's so obvious, he doesn't want to be seen as beating up on Fetterman. 00:57:37.840 |
And actually, Fetterman's issues are very unpopular in a state like Pennsylvania. 00:57:42.720 |
So I actually think for both reasons, Oz is going to win that I think Fetterman's manifestly 00:57:47.600 |
unqualified, but also I think his positions are fairly unpopular. 00:57:50.400 |
So I think Pennsylvania will will will almost certainly tip. 00:57:54.080 |
So let me pull up the chart here, just so people can see Ohio's going Republican. 00:57:57.840 |
And then Arizona, I think is really the interesting one where Blake Masters is now 00:58:02.560 |
tied after being behind Mark Kelly throughout this campaign. 00:58:18.320 |
He was he was doing really poorly, I think, because I think, listen, I think that I think 00:58:23.520 |
that Arizona is probably gonna be the closest race in the country. 00:58:28.640 |
Saks, what do you think are the biggest policy shifts that take place in this country? 00:58:39.360 |
So just, you know, talk to folks about what's on the docket from a legislative point of view, 00:58:44.160 |
going into the next Congress, with all these new candidates, 00:58:48.800 |
the reality is we have a separation of powers in this country, and you're going to have 00:58:52.640 |
divided government, the Republicans will will control Congress, the Democrats will control 00:58:58.160 |
And so as a result, you're going to be largely in a gridlock situation. 00:59:01.840 |
But gridlock may be a lot better than what we've had over the last couple of years. 00:59:05.520 |
So, you know, you've had basically this orgy of spending and money printing, 00:59:11.280 |
The other thing that's going to happen is Republicans may not be able to pass much 00:59:15.200 |
legislation, but they're gonna be able to do investigations. 00:59:17.600 |
And there's a lot of questions that need to be answered, I think, about still about COVID, 00:59:21.600 |
you know, these lockdown policies that we had, it started at the top at NIH, why did they happen? 00:59:26.480 |
We need to start having accountability for some of these horrible decisions that were 00:59:31.600 |
And there's been no willingness in Washington to hold anyone accountable. 00:59:34.240 |
At a minimum, they need to have some congressional investigations and find out why we pursued 00:59:38.880 |
such bad policies over the last couple of years. 00:59:41.360 |
By the way, did you see did you see what happened this week where the CDC, you know, after this 00:59:46.960 |
entire opioid epidemic, and all of these lawsuits, the CDC came out and actually said, Hey, listen, 00:59:52.800 |
we need to really make sure that we're getting access, putting opioids in the hands of Americans 00:59:59.040 |
who are really suffering with pain management and whatnot. 01:00:01.920 |
And I didn't read the article to really understand the details. 01:00:05.120 |
But I just thought it was an incredible headline where it's like, it's just it's so counter to 01:00:09.360 |
the narrative of what we've been told is happening, which is like, you know, over prescription and 01:00:14.080 |
If we learned anything during COVID is to question every organization, everybody and to really 01:00:21.440 |
While, you know, looking at these organizations, we trusted over time, I know, I look at the 01:00:26.560 |
world differently now that you couldn't say COVID was possibly a lab leak without having 01:00:31.280 |
your podcast taken down or being banned on YouTube. 01:00:34.400 |
And now ProPublica has done an investigation. 01:00:37.680 |
And they're saying along with Vanity Fair, and they're going to win a Pulitzer for this, I bet 01:00:40.720 |
that this conspiracy theory from two years ago is probably actually the leading theory and that 01:00:46.320 |
the Wuhan lab lab was showing, if you didn't see it, reporting an incident in late November of 01:00:59.360 |
There was an article in the Atlantic that came out over the past week called let's declare a 01:01:09.600 |
So basically, yes, all the experts who told us, Jason, that we weren't allowed to have an 01:01:14.880 |
opinion, because we weren't expert enough, that if we raise any questions about the origin of the 01:01:19.520 |
virus, that it might have come from a lab, that that basically needs to be censored. 01:01:23.040 |
The people who said we had to do lockdowns and implement all these authoritarian tactics. 01:01:26.800 |
Now they're saying that they need an amnesty. 01:01:29.920 |
And what that really means, no one's looking, no one's looking to criminally prosecute them. 01:01:34.080 |
What we're looking to do is have some accountability around the public policy. 01:01:37.360 |
What they want is they want to pull the expert card to say that they're the only ones who get 01:01:43.520 |
But then when it all goes horribly awry, they basically want to be completely insulated and 01:01:50.480 |
We're not going to give you full investigation. 01:01:55.680 |
I just want to say, sex, we're in alignment on this for a rare moment of peace on this podcast. 01:02:02.480 |
Shouldn't all Americans understand what happened after 911? 01:02:05.520 |
And what the failures were in our intelligence, just so we can get better. 01:02:10.800 |
But it's kind of crazy that you could people said to our podcast and other people who were 01:02:16.080 |
questioning it, forget about what political party you're in just want to understand how 01:02:21.200 |
What are the chances that this breaks out in the one or two places where they're studying 01:02:29.280 |
The other reason why you need to have accountability for this is that there is still a long tail, 01:02:33.600 |
especially around the damage that we did to our kids educationally. 01:02:37.760 |
Yes, now, and now the over prescription of stimulants. 01:02:40.480 |
And so if you don't have answers, you can't go after these problems like there was a there 01:02:46.480 |
was the like, stimulant prescription is now the single biggest epidemic in children. 01:02:52.640 |
It is now twice as prescribed as contraceptives and asthma drugs. 01:02:58.880 |
Why are we doing this to get them to score higher on a test to be more attentive in school? 01:03:03.120 |
Well, it's actually this negative feedback loop where these children were miseducated 01:03:12.080 |
It had huge psychological and academic damage to them. 01:03:16.960 |
Our test scores have fallen off of a clip relative to how we used to do relative to 01:03:23.280 |
I think the teachers unions have found a way to try to explain it. 01:03:27.440 |
To basically shield themselves from any sort of critique. 01:03:32.320 |
And so the loop and then part of that loop is then to look at a bunch of kids that are 01:03:37.520 |
underperforming in school. And instead of saying, well, maybe these lockdowns and masking 01:03:42.880 |
and all of these things that we implemented, actually had a huge impact. 01:03:52.480 |
Just so you guys know, the data is outrageous. 01:03:55.040 |
Twice as many prescriptions for stimulants as the sum of contraceptives and asthma drugs 01:04:03.840 |
Yeah, it's not that suddenly everybody's got ADHD. 01:04:09.600 |
And we're going to use stimulants to have them catch up. 01:04:11.680 |
We know, but we should be doing summer schools, after school programs, we can whatever, we 01:04:16.880 |
failed them because of our response to COVID. 01:04:18.880 |
That is why we need answers to all that stuff. 01:04:20.560 |
Because you need to link these things together to have some real accountability. 01:04:25.040 |
Here is the just so we have the people see the numbers. 01:04:27.520 |
Here's the 538 poll of how Joe Biden's popularity has switched. 01:04:32.160 |
This is 654 days into his presidency started out really strong 54%. 01:04:41.760 |
Obviously, that dip started with the economy, it's the economy stupid. 01:04:46.880 |
And if we go down a little bit on the same page, and you zoom in on the left there, you 01:04:51.920 |
He started out much more popular than Donald Trump day by day. 01:04:55.600 |
And now he's just as unpopular as Donald Trump was at this point in his presidency. 01:04:59.360 |
Well, look, I mean, look, the setup is really interesting for 2024. 01:05:02.320 |
Because it's probably going to be the case that we're in the middle of a recession going 01:05:07.360 |
Maybe we'll be sort of like getting ourselves out of it. 01:05:10.720 |
But there'll be a lot of economic damage, high unemployment. 01:05:13.440 |
And, you know, typically, folks in power will have to sort of be held accountable for that. 01:05:19.440 |
It's a really interesting setup that both Gavin Newsom and Ron DeSantis have to figure 01:05:25.360 |
out now and navigate if they're going to get the nomination on each side. 01:05:28.640 |
And breaking news today, Saks would love to get your thoughts on this. 01:05:32.240 |
Axios says, and we'll go to Science Corner next, that Trump's going to announce on November 01:05:40.800 |
Look, I kind of have the Joe Rogan philosophy on this, which is why give it oxygen. 01:05:45.760 |
There's certainly no need to talk about it before it happens. 01:05:47.840 |
You know, we're not even past this election yet. 01:05:51.120 |
But, but hey, I want to go back to the Biden popularity, because I think part of the issue 01:05:55.920 |
here is what are the arguments that Biden is making to the country about why people 01:06:03.120 |
And he gave another speech on Wednesday night where he basically claimed that if you vote 01:06:08.480 |
for a different party, that that is a threat to democracy. 01:06:12.480 |
In other words, the perpetuation of single party rule is what you must do if you care 01:06:18.640 |
That is a sales pitch that's not going to appeal to anybody outside of the viewers of 01:06:24.080 |
He's not talking about the issues that really matter to the country. 01:06:27.120 |
You know, what the country wants to know is that he's focused on the economy, he's focused 01:06:30.960 |
on inflation, he's focused on crime, he's focused on the schools and fixing this learning 01:06:39.600 |
Instead, he's basically saying that the Democrats should be kept in power forever, because there 01:06:50.320 |
But that is not a reason, hold on a second, that is not a reason to keep 01:06:55.440 |
And actually, there's a liberal guy, a liberal Democrat named Josh Barrow, who wrote a pretty 01:07:02.240 |
And what he said is, "The message is that there's only one party contesting this election 01:07:08.000 |
that is committed to democracy, the Democrats, and therefore only one real choice available. 01:07:11.920 |
If voters reject Democrats' agenda or their record on issues including inflation, crime, 01:07:16.480 |
and immigration, they have no recourse to the ballot box. 01:07:23.120 |
And actually, he's a Democrat who is pointing this out. 01:07:26.720 |
But I don't think that Democrats are getting the message on this. 01:07:33.280 |
And they're gonna have to find a new sales pitch to the country. 01:07:35.280 |
Well, you know, and he does have a good sales pitch, doesn't he, Chamath, with these major 01:07:41.120 |
He had the infrastructure deal got done, the technology bill, and the chips. 01:07:48.960 |
The problem is that those things happened, frankly, too early in his presidency. 01:07:55.760 |
Can you just throw this up here for a second? 01:07:57.920 |
You know, Jason, you mentioned this cheaper gas thing. 01:08:01.040 |
But the reality is, if you look at this, we have now depleted our strategic oil reserve 01:08:08.400 |
So we are running out of oil that we can introduce into the market at effectively zero cost 01:08:16.320 |
And because we've lost our relationships with folks like Saudi Arabia, there's no way to 01:08:23.760 |
In fact, they're gonna cut supply so that they can control the prices that they have 01:08:33.360 |
Well, the only three places where you can have incremental supply of energy, which the 01:08:37.680 |
country still needs, is from Russia, Iran, and Venezuela. 01:08:43.120 |
And so, you know, all of these things, Jason, I think, come back and really put Biden in 01:08:48.240 |
a tough place because as as SAC says, he does have to answer to all of these things because 01:08:53.520 |
Look, I still believe in the Democrats, you know, I am hoping I gave a million bucks to 01:09:00.320 |
the Senate PAC trying to sort of tip the Senate, I really think it's important that we have 01:09:04.800 |
a split government because I've kind of I gave up on the house. 01:09:07.200 |
I think it's clear that the Republicans are going to win, but the Senate is still is still 01:09:12.640 |
And the reason is because I think that we need to sort of have stasis so that nothing 01:09:18.160 |
bad happens between now and 2024 because I think the economic conditions on the ground 01:09:25.200 |
And then just the one last thing I'll say is the instructive thing that I think we should 01:09:33.760 |
Because what happened in Germany is really interesting when the economy turns and inflation 01:09:39.040 |
is out of control and energy is out of control. 01:09:41.120 |
What they basically did was they sidelined the European Central Bank. 01:09:46.560 |
They stepped in with their own balance sheet and said, you know what, we're going to nationalize 01:09:51.440 |
And I know that this sounds crazy to say, but if it can happen in a place like Germany, 01:09:56.160 |
I know most people would say it'll never happen in America, but I'm not so sure. 01:10:00.560 |
And I think that you want to make sure that there's a split government so that these things 01:10:07.760 |
And so hopefully there's some, you know, common ground in a Democratic Senate and a 01:10:12.240 |
Republican House, and we just kind of get through 24 and see where the chips land. 01:10:16.560 |
And I still think it's going to be Desantis versus Newsom. 01:10:20.480 |
Friedberg, any final thoughts here on politics? 01:10:23.280 |
My first observation is that I think it's funny that Chamath and Sachs are funding opposite 01:10:31.280 |
Yeah, why don't you just guys just give the money to me and Friedberg to get a plane 01:10:36.800 |
I could think of other ways for you guys to use that money. 01:10:38.560 |
But David and I may have cancelled each other out. 01:10:40.960 |
I mean, so far, Peter Thiel made the better trade. 01:10:43.280 |
He's it looks like the Teal wave in the Senate. 01:10:45.440 |
So look, I would say my very broad statement is democracies evolve in a cyclical nature 01:10:53.360 |
You often see swings from one political party to the other. 01:10:57.360 |
And it's just the nature that once someone's been in office, they form the new establishment. 01:11:03.840 |
And then folks on the next election cycle want to vote against that establishment because 01:11:07.840 |
there are things that they want that they aren't being given today. 01:11:10.880 |
And therefore, the democracy forces a change from what is the current establishment back 01:11:16.560 |
And generally, political parties seem to kind of adopt whatever the other side is. 01:11:20.320 |
And that's how the cyclical evolution of democracy seems to play out. 01:11:23.840 |
The recent trend that has been more alarming, which I think we can kind of take pause to 01:11:28.320 |
notice is the rise of populism, where populism is this really kind of vehement, diehard opposition 01:11:34.960 |
to elitism and the establishments that everyone feels kept down by and everyone feels taken 01:11:40.800 |
And the rise of Trump, the rise of Bolsonaro, the rise of Boris Johnson, and I would argue 01:11:47.680 |
even the rise of AOC, Bernie Sanders and Elizabeth Warren, all similarly speak to the crying 01:11:56.000 |
voice of the democratic populations that they want to see these establishments taken apart. 01:12:08.320 |
They don't feel like the institutions that oversee us and are meant to service us are 01:12:15.920 |
The problem is like a normal pendulum would swing back and forth between one side and 01:12:20.320 |
With the rise of populism, you get such a strong push of that pendulum, it can knock 01:12:29.360 |
We saw the motion of Brexit knocking through a wall, and we saw these kind of very radical 01:12:36.560 |
outcomes and then the cost of those outcomes blow up in our face. 01:12:41.840 |
And as a result, I think we're seeing a bit of a receding of the tides right now away 01:12:46.560 |
from populism during this current electoral cycle, where folks are saying, you know what, 01:12:51.280 |
maybe we just need to have some sort of an establishment so I can feel safe and secure, 01:12:55.120 |
less than the volatility that I've experienced of late. 01:12:58.480 |
Look, I think you look at the economic mess we're in, okay, populist did not cause that, 01:13:02.960 |
okay, populist did not cause $10 trillion of money printing. 01:13:06.000 |
It was modern monetary theory, and the experts, the Fed who did that. 01:13:09.760 |
It wasn't populist, who created the great financial crisis of 2008 that caused the Zerp 01:13:14.480 |
and we're still living with all the downstream effects of that. 01:13:17.760 |
It was the experts on Wall Street who said they could manage all these derivatives and 01:13:22.240 |
the collateralized mortgage obligations and all that stuff that they lost control over. 01:13:27.040 |
I would argue that the CDC are the experts, yeah. 01:13:32.560 |
And on COVID, it was not populist who caused the horrible handling of that pandemic, 01:13:38.960 |
Remember, we were told it was a pandemic of the unvaccinated, then it turns out the vaccine 01:13:44.160 |
It was not populist who caused the reaction to the pandemic. 01:13:47.200 |
It was the experts, the CDC, and Fauci, and people like that who shut down our economy, 01:13:55.440 |
So, Freeberg, listen, you may not like this populist wave that we have in the country, 01:13:58.960 |
and I get that, but it's in reaction to something real, which is the failure of this expert class. 01:14:04.560 |
And if you want to stop having this populist wave rise up, we need to start having experts 01:14:11.360 |
in position of power who actually know what they're doing. 01:14:16.400 |
I don't have any opposition to the populist wave. 01:14:18.560 |
I'm making the observation that the effects of some of the populist movements have started 01:14:24.560 |
to become too volatile for people to feel like they should continue forward with that 01:14:30.720 |
Okay, I'm not kind of criticizing the populist movement. 01:14:33.200 |
I'm just saying that events like January 6th and the conditions in the UK, for example, 01:14:38.080 |
are making people say, "Wait a second, maybe I need to take pause on the extreme." 01:14:45.840 |
And Bolsonaro in Brazil, he actually just lost, and there was this big narrative that 01:14:51.840 |
somehow he was going to not relinquish power, and he just announced that he will relinquish 01:14:57.120 |
So, some of the stuff that is about how populists pose this great danger, I think, is threat 01:15:02.800 |
inflation, and that the threat is magnified by elites who want to stay in power. 01:15:07.760 |
And the truth of the matter is we need accountability for the people in power, and when they set 01:15:12.240 |
the wrong policies and decisions, they need to be replaced. 01:15:17.680 |
Yeah, I mean, I 100% just just my personal belief 100% agree accountability is what's 01:15:22.640 |
lacking most across all of these institutions. 01:15:25.760 |
Accountability, maybe competence, and also transparency and accountability. 01:15:31.280 |
I mean, there's no measured by through you want to hear there's no second Hold on. 01:15:36.480 |
There's no way to perfectly react to the pandemic. 01:15:39.360 |
But in your mistakes, owning them and explaining them would be much better than trying to obscure 01:15:46.240 |
Chamath, you're not if you want to hear an incredibly interesting interview. 01:15:50.720 |
Because it's very thought provoking of a modern progressive, but with a very different mindset, 01:15:58.800 |
or sorry, you know, maybe you don't want to call him a progressive, but is the 01:16:02.240 |
President of El Salvador, Naib Bukele, and he did this incredible interview with Tucker 01:16:08.880 |
I encourage everybody to watch it on both sides of the political spectrum. 01:16:14.640 |
Did we just get an admission that Chamath watches Tucker? 01:16:23.040 |
You know, because I try not to be a moment's ignoramus. 01:16:31.920 |
And it's a it double clicks into, you know, the skepticism that smart people like him 01:16:39.120 |
the outsider class has with the insider expert class in a nutshell, if you want to see it, 01:16:44.080 |
I would encourage you to watch this interview because it's incredible. 01:16:48.160 |
Really, really, Jason, the peasants with pitchforks are rising up against this elite 01:16:53.280 |
class who've put themselves up, they've set themselves up as Lords, they want exclusive 01:16:59.760 |
And we're about to overturn this establishment, because it is corrupt. 01:17:07.760 |
It would be great if the people who work for us were confident back on Megan 01:17:13.120 |
You know, I think that's why people are opting out of this is they don't feel 01:17:17.200 |
that there's a level of competence in these institutions, nor ownership and 01:17:23.520 |
And it really is frustrating, whether it's education, or it's health, or, you know, 01:17:29.200 |
and any of these topics we've talked about here on the show, let's go to science corner and we 01:17:36.560 |
I think we were going to cover the Facebook meta announcement that their AI research team 01:17:43.440 |
had generated the physical structure of 617 million proteins from these metagenomic 01:17:51.440 |
And so remember, alpha fold made this big announcement that they had highly accurate 01:17:56.560 |
predictions of protein structure, the three dimensional shape of proteins. 01:18:00.240 |
And remember, proteins are kind of the machines of biology that do everything from 01:18:04.000 |
catalysis to enzymes where they break stuff down. 01:18:06.720 |
And they're like, you know, they have all this structure that allows them to do specific 01:18:11.680 |
And proteins are coded in DNA, every three letters of DNA codes for an amino acid, a 01:18:18.640 |
And so you know, we have about a million species, where we've sequenced the entire 01:18:24.720 |
genome of those species, only about 3000 animals, by the way, including humans, half a 01:18:30.160 |
million from bacterial species, and then a bunch of viruses and other stuff, but but 01:18:34.480 |
call it about a million species that we've sequenced. 01:18:37.120 |
And so, you know, earlier this year, Google's alpha fold project published the 3d 01:18:43.040 |
structure of 200 million proteins that they had derived from the whole genome databases 01:18:48.400 |
that existed, where we've gone through and figured out what's the full DNA sequence of 01:18:52.800 |
Now, when you look at the DNA in the environment around us, you were just to take the DNA 01:18:59.520 |
out, it turns out that we have seen very little of that DNA, the vast majority of DNA that 01:19:06.240 |
you would find in a teaspoon of soil, for example, we've never classified, it's not 01:19:11.360 |
part of a species that we've actually built the whole genome around, we may not even know 01:19:17.520 |
And so when you take a teaspoon of soil, you'll get about 100 billion microorganisms in that 01:19:25.120 |
But you don't see those species because the way DNA sequencing or shotgun sequencing 01:19:28.640 |
works is DNA is chopped up into little 250 base pair likes little 250 strands, and those 01:19:37.760 |
And then statistically bioinformatics puts together all of that little DNA segments and 01:19:43.600 |
tries to create long strands of DNA to figure out what the genes are, or what the whole 01:19:48.880 |
And so shotgun sequencing gives us kind of a snapshot of the DNA. 01:19:52.640 |
But until we've done the hard work of figuring out the whole genome, we don't know what 01:19:58.880 |
So when you take a sample of soil, or you take a sample of human poop, and you sequence 01:20:03.440 |
it, or even a teaspoon of ocean water, and you just sequence the DNA in it, you get all 01:20:08.640 |
of these little segments of DNA that we've never seen before. 01:20:11.680 |
And you can string them together statistically, because you get lots and lots of copies of 01:20:18.480 |
And a gene is a segment of DNA that codes for a protein. 01:20:21.440 |
And those genes make up the metagenome, or the combination of all the genes that we find 01:20:29.200 |
And that metagenome comes from millions of species that we've never seen before. 01:20:34.080 |
So what alpha, what they did at meta is they took all of those genes that we pull out of 01:20:38.800 |
the soil, or we pull out of the ocean, and they picked a bunch of random samples. 01:20:42.080 |
And they then predicted the physical structure of the proteins from just those genes, without 01:20:51.200 |
And this gives us a whole new universe of proteins that we've never classified before, 01:20:57.680 |
Now, I will just kind of speak a little bit critically about it. 01:21:01.360 |
Number one, they didn't do what alpha fold did. 01:21:03.600 |
What alpha fold did is they took 3d structures from typically x ray crystallography, then 01:21:08.400 |
they took the DNA code, and they built machine learn models to figure out the 3d structure 01:21:14.160 |
What these guys did at meta is they took the 3d structures and the code, and they basically 01:21:20.640 |
did a fill in the blank, they found all the metagenome data out of the samples, and a 01:21:26.240 |
And they filled in the missing blanks, using kind of common protein structure that existed 01:21:32.080 |
out there in the wild that we already knew from the alpha fold data. 01:21:36.720 |
And as a result, it allowed them to very quickly build these 3d models versus doing the hard 01:21:43.040 |
So they claim that it was 60 times faster, but it's actually an entirely different technique. 01:21:47.680 |
And the second thing is that they represent that only about a third of it is high quality, 01:21:51.520 |
meaning only about a third of the proteins that they've created structure for are really 01:21:55.680 |
useful or that could be kind of applied in terms of this is the real representation. 01:22:02.720 |
proteins can form the basis of new medicines. 01:22:05.280 |
So you know, we can find proteins in the soil, genomes in the soil and proteins in the soil 01:22:10.400 |
that can kill certain fungal pathogens that can kill bacteria, and those can be turned 01:22:14.800 |
into fungicides, they can be turned into antibiotics, we can find proteins that bind to specific 01:22:20.240 |
things, we can find proteins that fix nitrogen from the atmosphere. 01:22:23.760 |
And those proteins can be turned into new types of fertilizer. 01:22:26.560 |
So you know, searching through this universe of proteins that exists in the metagenome 01:22:32.160 |
will allow us to find new molecules to do new and interesting things with in the applied 01:22:38.080 |
And I will say like, this is what would the output of these be is what everybody's going 01:22:44.400 |
I mean, the idea of the metagenome is rather than start with the species and then take 01:22:51.760 |
They're in this, they're in the ocean, they're in the soil. 01:22:53.760 |
And there's millions of genes, hundreds of millions, billions of genes that we've never 01:23:01.760 |
But the number of proteins that could exist is more than the number of atoms in the universe. 01:23:07.760 |
So 20 to the 200th power 20 to the 300th power 20 to the 1000th power, meaning how many different 01:23:15.200 |
That's more than there are atoms in the universe. 01:23:16.960 |
So the best place to start is what evolution has already given us all the proteins that 01:23:23.120 |
So let's go find those proteins in the environment. 01:23:25.520 |
And then let's figure out what do we think they can be used for? 01:23:27.680 |
Can they be used in industrial applications in medicine? 01:23:34.560 |
And so you know, a lot of drug discovery, mines proteins, it tries to find proteins 01:23:40.160 |
and figure out what can these proteins be used for. 01:23:42.960 |
And now we have all these new data sets of proteins that are being generated from these 01:23:49.440 |
I mean, you know, look at the world around you look everywhere up and down on the walls 01:23:54.720 |
There are billions of species of organisms that we've never classified before that are 01:23:59.120 |
making billions of unique proteins that we've never classified before. 01:24:02.960 |
And any one of them could unlock an amazing commercial opportunity for industry. 01:24:08.160 |
So and for medicine and for human health, and so on. 01:24:10.800 |
That's what's really exciting about this ability to kind of mine the metagenome. 01:24:16.640 |
We have gotten the precursors to DNA for meteorites. 01:24:21.680 |
If I understand correctly, what do they call them? 01:24:30.480 |
I mean, etc, like things that exist in DNA that are precursors, we've never had DNA from 01:24:37.920 |
space, obviously, but we could at some point start to find DNA out there in space. 01:24:42.160 |
And this could have an even crazier impact on what we built here. 01:24:45.040 |
Is that the next card to turn over after we know what's here? 01:24:50.960 |
Like, I think, look, if there's DNA that's coming to us from meteorites, call it a couple 01:24:55.360 |
hundred genes, you could pick up a piece of soil and find over a billion genes in that 01:25:04.880 |
And the low cost of DNA sequencing and shotgun sequencing, coupled with bioinformatics, where 01:25:10.160 |
So just to give you guys a sense, when you take a teaspoon of soil, and you get the DNA 01:25:13.920 |
out and you read the DNA out of it, sequence the DNA, that's potentially 10s of gigabytes 01:25:19.840 |
And then you could do that millions of times over. 01:25:22.160 |
And then you statistically can find genes, and then statistically estimate what they 01:25:26.160 |
physically look like, what those proteins look like. 01:25:28.720 |
And then you can start to build models around which ones do we want to try and use for drug 01:25:35.600 |
Just in terms of what we have here on Earth, and the tools are getting so cheap and so 01:25:41.040 |
There are labs that are all over the world starting to kind of spring up to do this work. 01:25:47.040 |
It's kind of, you know, just to put two ideas together. 01:25:51.280 |
I've said before, like the two big investable themes that I'm orienting my organization 01:25:57.040 |
One is that the marginal cost of energy goes to zero. 01:26:00.720 |
And the second is that the marginal cost of compute goes to zero. 01:26:03.440 |
And the second one is really about shifting compute to more parallelism on GPUs and ASICs 01:26:09.760 |
But that's why all of this stuff is possible. 01:26:12.240 |
The fact that, you know, Meta can do this and Google can do AlphaFold is largely because 01:26:18.080 |
the cost of all of this stuff is, you know, trivial for these kinds of companies. 01:26:23.200 |
It's going to move science, in my opinion, out of this in vivo in vitro experimentation 01:26:31.040 |
And so those who can actually build learning machines will solve some of the most important 01:26:40.640 |
When do you think this stuff actually hits Friedberg, our life? 01:26:44.560 |
That's always when people talk about these discoveries. 01:26:47.120 |
Yeah, a lot of people don't realize it, but so many molecules that are used in agriculture, 01:26:52.080 |
like fungicides to kill fungus in the fields, those are derived from this sort of work. 01:26:57.200 |
A lot of antibiotics, a lot of medicines are already derived from mining genomes, finding 01:27:02.880 |
new proteins and seeing what those proteins can do. 01:27:05.760 |
Because these proteins didn't evolve in the environment randomly. 01:27:10.320 |
And in many cases, we can take that thing that they do and then harness it into a product. 01:27:16.160 |
And this this affects everything material science. 01:27:29.680 |
Oh, by the way, so many, so many of freeberg stands were afraid, Jay cal that you and I 01:27:36.640 |
And so for all these stands, I just I hope you guys can exhale. 01:27:41.920 |
Have some, you know, eggless mayo and enjoy your weekend. 01:27:56.840 |
And instead, we open sourced it to the fans and they've just gone crazy with it. 01:28:13.840 |
That's my dog taking a notice in your driveway, Saks. 01:28:21.840 |
We should all just get a room and just have one big huge orgy because they're all just useless. 01:28:25.840 |
It's like this sexual tension that we just need to release somehow.