Michael Mina: Rapid COVID Testing | Lex Fridman Podcast #235

00:00:00.000 | The following is a conversation with Michael Mina, his second time on the podcast.

00:00:04.800 | He's a professor at Harvard doing research on infectious disease and immunology.

00:00:10.960 | In my view, the most powerful, doable, and obvious solution to COVID-19 from the very beginning is rapid at-home testing.

00:00:20.320 | This is what Michael has been talking about and writing about since the beginning of the pandemic.

00:00:25.520 | The accuracy of these tests is high for the task of detecting contagiousness, which is what matters.

00:00:32.240 | Hundreds of millions can be manufactured quickly and relatively cheaply.

00:00:36.240 | Privacy and individual freedoms are preserved.

00:00:39.360 | I believe that if you give people the power of information, information about whether they are contagious or not,

00:00:46.640 | they will do the right thing at scale, all while respecting their freedom and minimizing the destructive effects of the pandemic on our health and our economy.

00:00:57.760 | This solution was obvious in May of 2020.

00:01:00.560 | It was obvious when Michael and I spoke the first time a year ago, and it is obvious today.

00:01:06.480 | We talk about why it has not yet been done and how we can still do it.

00:01:12.160 | This is the Lex Friedman Podcast.

00:01:14.360 | To support it, please check out our sponsors in the description.

00:01:17.840 | And now, here's my conversation with Michael Minna.

00:01:22.360 | We spoke a year ago about rapid at-home testing, and I think you think it should have been, still should be, a big part of the solution to COVID.

00:01:33.360 | So let's recap.

00:01:34.960 | Where do things stand today in terms of rapid at-home testing?

00:01:40.720 | Well, it's certainly something that you're right, I do think we should have them today.

00:01:47.560 | We've now had almost 20 months of living in anxiety, uncertainty, being afraid for our health, for our family's health, for our friends, you know, shutdowns, economic instability.

00:02:01.920 | Everything has been uncertain because of this virus.

00:02:05.320 | And then there's this little test, and it's the first time for many people that they're using it and they're feeling empowered.

00:02:12.680 | They're feeling like they can control their little slice of this pandemic.

00:02:17.120 | So as these tests have come out and more and more and more Americans have had an opportunity to go and buy them from, you know, CVS or Walgreens or wherever they're at, I think that it's really shifting the tenor of the discussion.

00:02:32.920 | For a long time, all of 2020, it was like, I often felt like it was me and a few other people against the world.

00:02:40.720 | You know, these tests should be public health tools.

00:02:44.760 | These tests are infectiousness indicators.

00:02:47.200 | They shouldn't be compared to PCR.

00:02:49.440 | You know, all of these different things.

00:02:51.040 | And we could, of course, go through and recap what the benefits and the metrics are that we should be looking at.

00:02:58.520 | But the point is, last year and most of this year was about educating scientists, educating public health leaders, educating physicians to get them to understand that there is a different reason to test in a pandemic than purely diagnostics and transmission blockade and severing transmission chains is a big one.

00:03:19.080 | So now I think we're at a point where people are now understanding.

00:03:22.760 | And they're understanding because they are feeling it.

00:03:25.000 | They're holding it.

00:03:26.160 | And they're doing it.

00:03:26.800 | And they're seeing they're feeling the delight of seeing a negative and saying, I feel more comfortable.

00:03:32.320 | It's not perfect, but it's pretty darn close to perfect to allowing me to go and see my mom without mistakenly infecting her or whatever the story might be.

00:03:44.560 | And now that that's happening, I think all of a sudden we're seeing a massive change politically for these tests.

00:03:52.240 | Biden just came out the COVID-19 action plan the other day.

00:03:55.080 | And one of the main pillars of it was testing and in particular, bringing rapid tests, scaling them up.

00:04:01.760 | So on that front, I think finally, there is success.

00:04:06.760 | People are actually understanding.

00:04:08.320 | And I haven't stopped beating this drum for far too long.

00:04:12.320 | And I hate rapid tests now.

00:04:15.240 | So maybe it's good to step back.

00:04:17.800 | Would you say most Americans have not taken a rapid at-home test?

00:04:21.120 | Absolutely.

00:04:21.880 | Most have definitely not taken a rapid test.

00:04:24.400 | So like many of them probably don't know.

00:04:26.640 | They kind of probably say testing, they have like memories of testing, like PCR testing.

00:04:33.400 | They have to go into somewhere and they have to like a swab deep in their nose.

00:04:38.720 | And that's the experience.

00:04:40.160 | Or maybe if you have to travel like Canada or something like that, you have to get tested, that kind of stuff.

00:04:45.600 | So what are rapid at-home tests?

00:04:48.880 | Yeah, so the rapid at-home tests are, I like to call them paper strip tests, simple.

00:04:55.680 | They're simple tests that, I wish I brought some today, but I didn't.

00:04:59.960 | They're simple tests that you swab.

00:05:04.960 | At the moment, most of them use a swab that you just swab the front of your nose.

00:05:08.600 | So it's not one of the deep swabs that goes into your brain.

00:05:12.920 | And so it's not very uncomfortable.

00:05:15.680 | It's just like picking your nose, if you will.

00:05:18.120 | And you put that swab into a little tube and the tube has some liquid in it.

00:05:27.320 | And then you put a few drops of that liquid onto a paper strip or you drop the paper strip

00:05:32.640 | into the tube, just like one of those indicators for the pool.

00:05:38.160 | And if you, just like a pregnancy test, then if you get two lines, you're positive, one

00:05:42.400 | line you're negative.

00:05:44.400 | It's super simple.

00:05:45.400 | It takes 30 seconds once you know how to do it of hands-on time and you wait around 10

00:05:50.240 | minutes, and then you read the result.

00:05:53.280 | They are extraordinarily effective to answer one question, am I infectious?

00:06:01.200 | And that is the public health question that we need to answer and consistently ask during

00:06:07.800 | this pandemic.

00:06:08.980 | Are you infectious?

00:06:10.280 | Am I infectious?

00:06:11.360 | Because it's only when we know that we're infectious that we can be empowered to not

00:06:16.180 | mistakenly infect others.

00:06:19.440 | The PCR test is a little different.

00:06:22.120 | And we can go into the pros and cons, but one of the major differences is that a PCR

00:06:30.480 | test gets a lot of people talking about the PCR test say it's much more sensitive.

00:06:39.240 | And at an analytical level, it is, it can detect one molecule instead of 100,000.

00:06:46.800 | But for public health, we don't want a test that can detect one molecule.

00:06:52.440 | In fact, that has created a net negative for public health.

00:06:56.820 | We just want to know, am I infectious?

00:06:58.760 | And to know that question, to know if I'm infectious, I only need a test that is going

00:07:04.300 | to be positive if I have a high viral load, like a million.

00:07:09.160 | And when you're in the virus grows so fast, it will grow from zero to a billion in a day.

00:07:14.440 | So you don't really need even on the front end of an infection, you don't need better

00:07:17.840 | sensitivity.

00:07:20.060 | If the trade off is that you don't get the result for one, two or three days, you absolutely

00:07:24.840 | want a rapid result that can tell you yes, you're infectious, you're transmitting to

00:07:29.560 | others right now.

00:07:32.200 | And I'm going to give you the result right now.

00:07:34.500 | So it is a much more effective tool, because it's fast because it's accessible, we can

00:07:38.940 | use them in the home.

00:07:41.260 | And there's some issues with using them at home, we can talk a little bit about what

00:07:44.920 | those issues are like reporting and how do you, is everything on the honor system if

00:07:49.500 | you have a test that you're taking at home and you use it to go to work.

00:07:53.360 | But they can be accessible.

00:07:55.360 | PCR has to go into a lab, it takes a lot of time for somebody to get a PCR test, they

00:08:00.280 | either have to go online and order it, it takes the next day for it to come back.

00:08:04.280 | They swab themselves, they ship it out the next day, and then they get a result two days

00:08:07.480 | later.

00:08:09.520 | That's four days minimum for the most part.

00:08:11.720 | And you know, at that point, you're not even infectious, even if you did happen to be infectious

00:08:15.600 | when you first ordered the test.

00:08:18.000 | So it's really the speed of these tests and the accessibility and distribution of them

00:08:21.720 | that makes them so immensely powerful.

00:08:23.560 | >> So you have this like amazing graphic you tweeted.

00:08:26.920 | It's exactly what you're saying, which is a rapid antigen test answers the question,

00:08:33.280 | am I currently infectious?

00:08:35.400 | And you have, I think, a comparison of seven different tests based on the viral load.

00:08:42.360 | And based on the viral load across these different tests, you look at the likelihood of infectiousness.

00:08:49.040 | So what does this graphic show?

00:08:50.520 | We can overlay that for people.

00:08:52.400 | I think it's just really nice and really clear.

00:08:54.880 | >> Yeah, so what that's showing is that we can never ask what's the sensitivity of a

00:09:00.520 | test, and just let that be the answer.

00:09:02.400 | That's what the FDA does currently.

00:09:04.880 | And that question doesn't mean anything.

00:09:07.040 | We have to say, what is the sensitivity of the test to detect what?

00:09:11.960 | And so we can have different viral loads.

00:09:13.800 | For example, we can have, you can have a viral load of one, or you can have a viral load

00:09:18.400 | of a trillion.

00:09:19.960 | And a PCR test will tell you that you are positive, regardless of whether it's one or

00:09:26.000 | a trillion.

00:09:28.240 | Now so we can't ask the question, how sensitive is a rapid test compared to PCR, because that

00:09:34.040 | covers the whole gamut.

00:09:35.080 | What we really want to say is, how sensitive is the rapid test to detect me if I am infectious?

00:09:40.900 | And that gets to about 97% or so sensitive.

00:09:45.820 | If the question is, how likely is it to detect me if I'm a super spreader, that's a really

00:09:50.280 | important one to be able to detect.

00:09:52.460 | They're all about 100% sensitive.

00:09:54.920 | So if you have extraordinarily high viral loads to the point where you might be a super

00:09:58.520 | spreader, these simple rapid tests will essentially always catch you and tell you you're positive.

00:10:04.000 | And then as you go down the line, if you're no longer infectious at all, then these rapid

00:10:10.000 | tests might have a 0% sensitivity compared to PCR.

00:10:14.640 | But that's actually a good thing.

00:10:16.320 | The FDA and others look at it as though it's a bad thing, because they average it all together

00:10:20.720 | and say, oh, this is only a 40% sensitive test compared to PCR.

00:10:26.460 | But that's not the right way to look at it.

00:10:28.520 | You want to say, well, out of all of the samples, how many of them were not transmissible?

00:10:32.080 | How many were mid, moderate, high, extremely high, super spreader?

00:10:36.200 | And you should at the very least create a weighted average based on transmissibility

00:10:39.480 | potential.

00:10:41.040 | We don't do that.

00:10:42.040 | And that's why nobody in America has these tests, or that's why they're very rare, because

00:10:46.840 | we have slowed down their authorization because of that misunderstanding that they don't have

00:10:52.780 | to be 80% or 90% sensitive compared to any time PCR positivity.

00:10:58.620 | They need to be 80% or 90% or more if you're infectious.

00:11:02.300 | And for that question, they're like 95% up to 100% sensitive when you're most infectious.

00:11:08.660 | So you have a lot of viron particles in you.

00:11:11.420 | So that's what it means when you say viral load.

00:11:14.960 | That means you're going to be very infectious.

00:11:16.940 | The more you have, the more infectious you are.

00:11:19.180 | And this test is basically very good at detecting when you're very infectious.

00:11:25.940 | - Why don't we have rapid at-home tests?

00:11:29.820 | So you said there's a bit of confusion.

00:11:31.420 | FDA is involved.

00:11:33.580 | You've talked about, you continue to talk about that these at-home tests are classified

00:11:40.180 | as I guess medical devices.

00:11:41.820 | - That's right.

00:11:42.820 | - And so because of that, FDA is looking at them differently than they probably should

00:11:48.660 | be looked at.

00:11:49.940 | So what's the problem here?

00:11:53.660 | Can you sort of explain what does it mean to be a medical device?

00:11:56.740 | Why is that an issue?

00:11:58.140 | Where is the FDA messing up?

00:12:01.300 | - When we declare something as a medical device and we evaluate it as a medical device, then

00:12:06.300 | it makes sense that the comparison, if you're trying to get a new one onto the market, that

00:12:11.900 | the comparison would be against a gold standard medical device for that purpose.

00:12:17.260 | So PCR is currently the gold standard, or at least in the eyes of the FDA, the PCR test

00:12:25.540 | is the gold standard medical device.

00:12:29.900 | And that's because it's so sensitive.

00:12:33.500 | As a physician, I have one patient in front of me at a time.

00:12:37.820 | And that patient comes to me and I don't have to care about the 99.9999% of people in the

00:12:44.140 | world who are not in front of me.

00:12:46.740 | I only care about that one patient.

00:12:49.260 | And so when I get a sample from that patient and that patient's saying, "Doc, you know,

00:12:53.420 | I don't feel well.

00:12:54.420 | I haven't been feeling well for the last few weeks.

00:12:56.060 | Do you think this is COVID?"

00:12:57.700 | Well, for that question, I want to have the absolute best sensitivity test, regardless

00:13:04.700 | of what it means for transmissibility, because my patient isn't sitting in my office saying,

00:13:09.220 | "Doc, do you think I'm infectious?"

00:13:11.740 | They're saying, "Doc, do you think I have recently been or am infected?"

00:13:15.940 | And these are totally different things.

00:13:17.500 | One is medicine.

00:13:19.660 | And if the patient's infected, you know, time isn't of the essence because they're sitting

00:13:23.620 | there in my office.

00:13:24.620 | I can say, "Look, I'm sorry you're not feeling well.

00:13:27.340 | Let's get a PCR test on you.

00:13:29.140 | We'll be able to tell you if you have any evidence that there has been recently an infection

00:13:34.380 | inside of you.

00:13:36.460 | And you'll get the result in a couple days.

00:13:39.580 | And it might be expensive, and so insurance is going to pay for it.

00:13:42.980 | And you're just one person.

00:13:44.220 | And so I don't really care how many resources it takes to get you this answer."

00:13:49.140 | On the other hand, there's rapid and there's public health testing.

00:13:52.540 | And public health testing is, it has to account for all of the people you're not seeing as

00:13:58.660 | well as the person you're testing at the moment.

00:14:00.860 | So accessibility becomes a central theme.

00:14:04.980 | Frequency of tests, it has to account for all the days that you're not sitting there

00:14:07.940 | in front of your doctor's office getting a test as well as the one you are.

00:14:12.300 | So it has to say how frequently.

00:14:14.140 | What if you're infected tomorrow, but you're at the doctor's office today getting a negative

00:14:17.620 | COVID test?

00:14:19.340 | That PCR test at the doctor's office today is going to do nothing to let you know that

00:14:23.820 | you get exposed and infected tomorrow.

00:14:26.340 | The only way to know that is to be testing yourself frequently.

00:14:31.740 | And the reason it matters is that these tests can be accessible if we are okay with saying

00:14:37.500 | the real purpose of a public health test is to answer the question, "Am I infectious?"

00:14:43.740 | The reason we want to answer that is if you're infectious, that's when you isolate.

00:14:47.820 | We actually don't want to isolate positive PCR, PCR positive individuals who are no longer

00:14:55.580 | infectious.

00:14:56.700 | That's bad public health practice.

00:14:59.620 | If I haven't been infectious for three weeks, I don't want to have somebody tell me that

00:15:02.740 | I need to go and isolate for 10 days just because I happened to use a PCR test today,

00:15:09.020 | three weeks after I was infectious.

00:15:11.100 | And furthermore, I definitely don't want the public health agency to come and round up

00:15:16.800 | all the people I was with last night and say, "You guys have to quarantine for 14 days because

00:15:21.540 | you were with Michael who wasn't infectious yesterday."

00:15:24.660 | It's nonsensical to do that.

00:15:27.260 | It's a huge disincentive to actually get tested.

00:15:29.740 | That's exactly right.

00:15:30.820 | Huge disincentive to get tested.

00:15:32.580 | People, if it's too sensitive, especially with flights, things like that, we shouldn't

00:15:37.340 | be stopping people from taking a flight if they haven't been infectious for 60 days.

00:15:42.260 | And to be clear, people are only infectious for somewhere between three and seven days,

00:15:49.140 | but can be positive on a PCR test for 30 to 70 days.

00:15:54.040 | So it's potentially a tenfold difference in terms of how long you're PCR positive versus

00:15:59.700 | how long you're infectious.

00:16:01.900 | So we don't want to be taking people during those 30 to 70 days and saying, "You need

00:16:06.020 | to isolate just because you go and get a swab," or, "You can't go on your trip just because

00:16:10.620 | you had COVID last month."

00:16:12.760 | That's not good use of a test.

00:16:17.080 | So the reason we don't have these tools right now is because when we evaluate a rapid test

00:16:24.020 | as a medical device, the FDA says, "Well, this has to achieve the properties that we

00:16:30.600 | expect from a medical device," which again, doesn't have to take time into account, doesn't

00:16:36.740 | really have to take cost or resources or scalability or access into account.

00:16:41.140 | It only takes sensitivity and specificity to catch molecules.

00:16:47.100 | And so just by definition, I mean, it is a mathematical fact that if you have a perfect

00:16:54.300 | public health test for COVID, which means that it would be 100% sensitive and 100% specific

00:17:01.220 | for contagious people or for the infectious stage of an infection, then it literally can't,

00:17:10.260 | it is an impossibility for that test to achieve an 80% sensitivity at a population level against

00:17:18.300 | a medical device, which is what the FDA asks for.

00:17:20.580 | And that's because you're only infectious for maybe 20%.

00:17:24.980 | So theoretically, it should only have a 20% sensitivity against the PCR while still being

00:17:31.380 | a perfect medical, a perfect public health test.

00:17:35.020 | - And the test is answering the question, am I infectious?

00:17:37.980 | That's what you're testing for, not for the exact counting of the viron particles in your

00:17:42.700 | system.

00:17:43.700 | - That's exactly right.

00:17:44.700 | - Okay, so why are we still here?

00:17:49.000 | So have you had conversations with folks?

00:17:51.860 | You said that there's a bunch of leaders that are kind of starting to wake up to this idea,

00:17:57.740 | but why is this taking this so long?

00:18:00.700 | Why don't we still have hundreds of millions of at-home tests?

00:18:06.500 | - The reason it's taking long, I think, is because every agency and government is generally

00:18:14.200 | deferential to the FDA.

00:18:16.580 | And in this context, I would argue that government hasn't been particularly creative.

00:18:24.200 | So for example, last year, when Trump was still president, I would, or in the transition,

00:18:30.240 | I recall talking to the White House a number of times and saying, "Here's a plan to give

00:18:34.880 | us our lives back."

00:18:36.080 | I think that was actually the title of the Atlantic article.

00:18:39.280 | And this plan can stop shutdowns, it can stop outbreaks, it can allow society to keep running

00:18:45.760 | and could have prevented the outbreaks of last winter and fall and saved hundreds of

00:18:51.920 | thousands of lives.

00:18:54.640 | So when I bring that to the White House or to the government, the federal government,

00:18:58.320 | whoever it might be, and I say, "Here's a plan, this would work."

00:19:02.200 | They say, what I get back is, "This sounds really interesting, Michael.

00:19:06.580 | It looks like it checks out, but there's one problem.

00:19:09.540 | We don't have the test, there's no scale."

00:19:12.160 | And that's kind of where it all dropped.

00:19:13.760 | It's like this defeatist attitude of like, "Oh, don't have the test, so we can't act

00:19:19.100 | on it."

00:19:20.200 | But now it's really changing.

00:19:22.760 | And so that's really where things have been.

00:19:24.080 | And so nobody's paid attention.

00:19:25.240 | It's always been this esoteric thing that, yeah, maybe one day we'll get around to it,

00:19:29.960 | but really it's not that important.

00:19:31.400 | And the pandemic's going away, but this was like 100% predictable, everything that's happening

00:19:36.960 | today.

00:19:38.240 | We predicted it last year.

00:19:40.240 | This isn't like rocket science or anything.

00:19:41.600 | - The variants and all those kinds of things.

00:19:43.920 | So the FDA, we can start to understand why, but also one question I want to ask, is it

00:19:50.440 | possible to go around the FDA?

00:19:52.600 | - Yeah.

00:19:53.600 | So why has the FDA not changed?

00:19:57.780 | And why has nobody tried to push the FDA to change?

00:20:01.680 | I think what the real reason is the FDA has one job around these tests, and it is to authorize

00:20:08.980 | them as medical devices.

00:20:10.400 | They haven't been charged with doing anything else.

00:20:14.160 | So in their eyes, they're doing exactly what they're supposed to do.

00:20:18.960 | They're evaluating these tests as medical devices, and they're telling company after

00:20:23.040 | company after company, "Sorry, you don't make the cut."

00:20:26.920 | And the only way to make the cut is really to kind of skew your clinical trials to favor

00:20:31.520 | the rapid test being positive, which isn't really good practice.

00:20:35.160 | We shouldn't be trying to skew clinical trials.

00:20:39.320 | But that's kind of what's happened.

00:20:41.160 | It's been forced upon the companies to do that.

00:20:44.640 | And so I think the FDA truly believes from the bottom of their heart that they are doing

00:20:48.880 | the right thing here.

00:20:50.840 | And I would argue that to an extent they are.

00:20:53.320 | They've been pretty hard on the FDA, but maybe the issue is a higher level issue.

00:20:58.880 | Like the in vitro diagnostics division is they get applications and they evaluate them,

00:21:03.920 | and the applications are for medical claims.

00:21:07.200 | That's however, because there's been a misunderstanding of these tests and the companies only know

00:21:12.440 | to apply for these as medical claims because there is no, there's nothing else in this

00:21:18.240 | country to apply for except a medical claim.

00:21:22.620 | So we don't have a public health pathway to evaluate a test and authorize a test.

00:21:27.400 | It doesn't exist.

00:21:28.400 | We have defunded and devalued public health for so long that we literally don't have a

00:21:34.360 | language for it.

00:21:35.360 | We don't have a law, a language, words.

00:21:38.160 | Is it called a public health test?

00:21:39.560 | Is it called something else?

00:21:41.080 | I call it a public health test because I'm trying to create a new definition here.

00:21:46.760 | But that's why nobody's acted because everyone says, well, there's no other pathway.

00:21:51.960 | So the FDA in vitro medical diagnostics division is the only pathway.

00:21:56.660 | So what I am trying to do is to say, look, the FDA very clearly states that they do not

00:22:05.420 | authorize or review public health tools and they don't authorize or review public health

00:22:12.260 | tests for COVID.

00:22:15.400 | So what I want the president of the United States to do is to utilize executive powers

00:22:22.420 | and take an executive action that can simply state one line.

00:22:27.020 | One line could potentially change all of this.

00:22:31.180 | And it's a pretty obvious and simple line.

00:22:33.720 | And it is that any tools used for public health testing during this public health emergency

00:22:43.020 | will be designated as public health tools.

00:22:46.520 | It's obvious.

00:22:47.520 | It's a public health emergency.

00:22:48.900 | It's a tool used for public health.

00:22:50.220 | It should be designated as a public health tool.

00:22:53.500 | If we can do that, if we can get that language out there so that that's the president's decision,

00:23:00.140 | then all of a sudden the FDA is off the hook.

00:23:03.080 | They're not trying to cram a square peg through a round hole.

00:23:07.880 | They can say, look, the antigen tests are not on us anymore, at least if they're going

00:23:12.780 | to be used for public health, like when you test a thousand people at a time or test a

00:23:19.020 | school classroom if they've been exposed.

00:23:21.500 | This is public health.

00:23:22.780 | And so then the CDC could take it over.

00:23:25.300 | The CDC could say, okay, what are the metrics we are interested in?

00:23:30.480 | And they could say, we're interested in a test that can catch you if you're infectious.

00:23:34.100 | So you want high viral load detection.

00:23:36.220 | That's fast, that's scalable.

00:23:38.440 | And hey, if your test has been used in Europe for months and has performed extremely well,

00:23:44.140 | then we'll give you a certificate by right immediately.

00:23:48.300 | And that could actually get hundreds of millions of additional tests into the United States

00:23:53.500 | tomorrow.

00:23:54.500 | So you need some kind of classification from an FDA or from somebody to call it a public

00:23:59.420 | health tool in order for it to be manufactured.

00:24:02.500 | Is it possible to just go around all of this and just for somebody to manufacture at scale

00:24:06.780 | tests?

00:24:07.780 | Well, if you did that and you just called them, you put a claim on them that called

00:24:13.740 | them public health tools, the FDA has a very weird view of this.

00:24:20.960 | And they will tell you that it's illegal, that it's a crime.

00:24:25.020 | Is there a way to say like Elon Musk did with the flamethrower, it's not a flamethrower?

00:24:32.020 | Believe me, I've tried to think of all the different approaches.

00:24:36.460 | You know, there's major inconsistencies here.

00:24:39.980 | So it's not like we don't have a precedent for a public health test, even during this

00:24:43.300 | pandemic.

00:24:45.100 | There is a very strong precedent.

00:24:47.740 | Pooled testing.

00:24:49.340 | We have companies like Ginkgo, right, based out here in Cambridge, that are working with

00:24:55.980 | 100 different labs around the country.

00:24:58.180 | So that might mean like not a ton of quality control over those labs.

00:25:02.140 | Doing, I mean, I don't want to say that they don't.

00:25:05.020 | I'm just saying the reality is if you're working with that many labs, it's hard to say.

00:25:09.260 | They're running pooled testing of millions and millions and millions of kids.

00:25:15.260 | So here you have a company that's testing in each pool, 5 to 25 kids at a time, millions

00:25:23.380 | of kids in a pretty distributed way across the country in all these different labs.

00:25:28.700 | And the FDA doesn't care at all.

00:25:30.500 | You don't need an EUA.

00:25:31.820 | It doesn't need a regulatory authority.

00:25:34.440 | It's collection on site.

00:25:35.440 | It's getting shipped to a lab.

00:25:37.260 | There's no oversight of it.

00:25:40.360 | So why does that have no oversight but a rapid test for the exact same purpose?

00:25:46.580 | You're just giving people immediate results instead of two day delayed pooled PCR results.

00:25:51.500 | So it's a much more effective tool.

00:25:53.920 | Why is the rapid test used for the same purpose, not designated as a public health tool, but

00:25:59.020 | requiring FDA authorization?

00:26:02.660 | It's a ridiculous reason, and it's because the FDA says that if a test, and this is actually

00:26:10.600 | CMS that says this and the FDA adopts it, if a test alters your behavior, if you get

00:26:18.560 | a single result and it's going to alter your behavior, then that is a medical device.

00:26:25.620 | But the thing that I find ridiculous is like, okay, but you can give a pooled test that

00:26:30.360 | alters 25 people's behavior at once.

00:26:34.120 | And that's not falling, like that's more risky.

00:26:36.500 | One person turns positive in the pool and 25 people have to be quarantined.

00:26:43.000 | And how do they evaluate the accuracy?

00:26:45.220 | So for people who don't know, pooled test is you're testing a small fraction of the

00:26:50.000 | people.

00:26:52.280 | And if one of them is positive, then you basically say we have to retest everybody in the pool.

00:26:58.260 | Or like- Yeah, so you take, let's say you have a school

00:27:01.020 | and each classroom, you might have 20 kids each swab their nose in a classroom and all

00:27:05.680 | those swabs go into a single tube.

00:27:08.220 | And then you rinse that tube out with some saline and you run a PCR test on that tube

00:27:13.000 | of 25 samples, 20 samples.

00:27:15.900 | And so if that tube turns positive in the PCR test, then all 20 or 25 of those students

00:27:23.300 | are now having to quarantine.

00:27:25.620 | And if there's no positive, then all 20 or 25 students are interpreting that their result

00:27:31.760 | is negative.

00:27:33.680 | So it really is ridiculous decision by the FDA to say that if the test itself only tests

00:27:40.520 | one sample at a time, it's medicine because it will tell you one person at a time if you're

00:27:45.200 | positive or if you're negative.

00:27:47.660 | But if you do it as a pool and you tell 25 people that your pool was negative, then that's

00:27:54.620 | somehow different.

00:27:55.700 | That's public health, not medicine.

00:27:57.680 | It doesn't make, there's no logic there.

00:27:59.420 | - Was it just personalities and accidents of history or something like that?

00:28:03.060 | For example, you talk about the public health tools and CDC, you look at masks.

00:28:09.700 | So masks were decided to somehow be an effective tool to help with the pandemic.

00:28:15.500 | So I'm sure the evidence that was used there was probably not as strong as the evidence

00:28:21.840 | supporting antigen rapid tests.

00:28:24.100 | I was very much reading a lot of research on masks.

00:28:27.700 | It's tricky.

00:28:28.700 | It's really tricky to show how well they stop the transmission of a virus, especially when

00:28:33.180 | you don't fully understand how the virus is transmitted or the viral load required, all

00:28:37.660 | that kind of stuff.

00:28:38.740 | But then the CDC pretty quickly decided masks or whatever, there's some oscillations back

00:28:43.340 | and forth, but then they quickly decided, everybody decided masks is a good tool.

00:28:49.820 | So masks being decided a good tool and then rapid antigen tests, not a good tool.

00:28:55.140 | Is that just like certain personalities who didn't speak up in a meeting or who did speak

00:28:59.780 | up in a meeting?

00:29:00.780 | Is this just like a weird roll of the dice or is there a better explanation?

00:29:04.980 | - I think it's somewhat of a roll of the dice, but I also think it's that testing.

00:29:10.940 | So doctors don't pretend to really understand much about fluid dynamics and how well masks

00:29:20.860 | are working.

00:29:21.860 | That's way out of their realm.

00:29:24.260 | Doctors do believe that they understand all aspects of the tests.

00:29:30.580 | And so the greatest barriers to rapid tests being brought to market or sort of being rolled

00:29:39.220 | out heavily and supported as public health tools, the greatest barriers came from physicians

00:29:46.260 | saying, "Hell no, we can't use a test that's not as sensitive as a PCR."

00:29:53.100 | And look at what happens if you use this antigen test and not a PCR test, you get people who

00:29:59.900 | are showing a positive on a PCR and negative on an antigen.

00:30:04.340 | And they just assume that that was a false negative on the antigen.

00:30:09.060 | For public health, I would call it a false positive on the PCR test.

00:30:13.560 | But this type of thinking literally does not exist in medicine.

00:30:18.740 | And I think the biggest problem here is that we placed physicians in decision-making power.

00:30:25.580 | We have, when this pandemic hit, everyone called up clinical laboratories, folks and

00:30:32.380 | microbiologists and physicians to ask, "Well, what kind of test should we use?"

00:30:36.300 | That kind of thing.

00:30:38.460 | And there is no training in medical school for this kind of public health work.

00:30:44.220 | You have to optimize on the right qualities of a test that have nothing to do with medicine.

00:30:51.220 | And then sometimes, if not frequently, they're actually at odds.

00:30:54.660 | And I'll give an example.

00:30:57.460 | Why the physicians, you could see why the physicians would have been against it from

00:31:00.460 | their perspective.

00:31:02.340 | And they say, if a physician is a TSA agent at the airport, a TSA agent, their role at

00:31:11.060 | any given time and the role they think that the instruments need to play is, "I want you

00:31:15.980 | to scan the bag as well as possible.

00:31:18.460 | This is the only bag that I'm interested in at the moment.

00:31:22.180 | And this is my lane.

00:31:23.800 | This is my bag.

00:31:25.640 | I want to make sure that my instrument's doing...

00:31:27.340 | I don't want the crappy instrument in my lane.

00:31:28.980 | I want to make sure that I'm doing everything I can."

00:31:31.500 | But what those TSA agents don't have to worry about is, "Well, how many other instruments

00:31:37.220 | are there in this airport?

00:31:38.540 | Is anyone getting through the lines here without going through security?"

00:31:42.380 | The average TSA agent doesn't have to worry about that.

00:31:44.340 | They literally have one job to do, and it's pay attention to this lane.

00:31:48.880 | If there's a big gap in the security line and people are flowing through without going

00:31:53.660 | through security, that's not on the TSA agent.

00:31:56.220 | That's not a big systematic problem of the system.

00:32:01.220 | And we can't expect that TSA agent to have ever even thought about that.

00:32:05.740 | That's not on them.

00:32:06.740 | They were trained to look at the bag.

00:32:09.700 | And that's kind of like physicians.

00:32:12.300 | And probably some physicians will hear this and feel like I'm insulting it.

00:32:15.900 | I don't mean to be likening the two professions or anything like that.

00:32:20.060 | But the point is that a physician has one duty.

00:32:24.780 | Do no harm to this patient.

00:32:26.800 | Time is of the essence.

00:32:28.380 | Scale.

00:32:29.380 | How many tests can my hospital perform in a day?

00:32:32.580 | How many tests can my county or country perform in a day?

00:32:36.700 | That's not a physician's training to think like that at all.

00:32:41.500 | And so what has happened is doctors got on board early and said, "Oh, hell no.

00:32:46.340 | We've seen these antigen tests before.

00:32:47.700 | They're not particularly sensitive compared to PCR."

00:32:50.700 | And early in the pandemic, there was like pissing matches between labs who had the most

00:32:54.700 | sensitive PCR.

00:32:57.200 | And it just distracted everything.

00:32:59.620 | It really, I was trying to say pretty early, like we don't need sensitivity.

00:33:04.820 | We just need frequency.

00:33:06.180 | We just need scale.

00:33:07.180 | We need to think differently because our only goal if we're doing frequent routine testing

00:33:12.100 | of asymptomatic people is not medicine.

00:33:14.620 | It's to say, "Do you need to isolate now?"

00:33:17.200 | And if you have a PCR test that's taking three days to return and you're like, "If I was

00:33:21.900 | currently spreading virus before I walked in here and you handed me," this actually

00:33:26.740 | happened to me today when I walked into Harvard.

00:33:29.280 | Today was my first day back into Harvard since February of 2020.

00:33:32.740 | I go in, I scan my badge and they hand me a PCR tube and they say, "Return this by noon

00:33:41.020 | or something before your workday is done."

00:33:43.900 | And I'm looking at it, I'm like, "What is this going to do?

00:33:48.000 | What if I'm super spreader right now?

00:33:50.060 | You're giving me free reign to walk around and infect everyone in the school and you're

00:33:54.300 | going to give me my result to tell me I did that in two days from now?

00:33:57.700 | It doesn't really make sense."

00:34:00.100 | - So who is supposed to be, so it's understandable that doctors kind of feel that way, just like

00:34:05.140 | you said, do no harm.

00:34:07.860 | Who is supposed to care about public health?

00:34:11.500 | Is it the FDA?

00:34:12.660 | Is there some other organization yet to be created?

00:34:15.660 | Is it just like with the military, the reason we have civilian leadership when you talk

00:34:21.580 | about war?

00:34:22.900 | Is it the president that's supposed to do like override FDA, override doctors, override

00:34:29.460 | and basically politicians in representing the people in a state of emergency make big

00:34:34.940 | public health decisions?

00:34:35.940 | Like who is supposed to do it besides you on Twitter?

00:34:40.020 | It's like most people really thinking about solutions to COVID will mention you or will

00:34:46.140 | mention this idea of rapid at home testing and you watch that happening, this discussion

00:34:54.380 | that this is an obvious part of the solution and the solution is not happening.

00:34:58.180 | So who is supposed to implement this idea?

00:35:01.300 | - I think the CDC that it should start there.

00:35:04.700 | - Override the FDA?

00:35:05.700 | - Well, I don't even think it needs to override it and that's why I think these should just

00:35:09.620 | be designated as a different tool so that the company is, it's not overriding, it's

00:35:14.700 | just saying, look, this isn't in your jurisdiction to the FDA.

00:35:19.020 | This is just a public health tool.

00:35:21.540 | But the problem is the Centers for Medicaid and Medicare Services designates any tool,

00:35:27.440 | just like FDA, they designate these as medical devices purely because they could change somebody's

00:35:31.980 | behavior based on the result of one test.

00:35:35.600 | So to change that at this point, unless you can get CMS buy-in, there is no designation

00:35:41.560 | as a public health tool.

00:35:43.700 | But the president can just say, these are public health tools.

00:35:48.680 | These are not to be regulated as medical devices if their goal is not medicine but public health.

00:35:55.780 | And if he does it, he does have the authority to do that as president and to say, I'm tasking

00:36:01.980 | the CDC to certify these tests or authorize them for use in the United States.

00:36:08.660 | And he has to say something like that.

00:36:10.620 | He can't come out and say, these are public health tools, have free reign, just any company

00:36:16.620 | start shipping them in the US because that would create pandemonium and we'd have a lot

00:36:21.140 | of bad tests.

00:36:22.940 | But there's a lot of really good tests out there.

00:36:26.400 | We just are taking like six to 12 months to run trials.

00:36:30.300 | They're failing because they can't keep up with PCR.

00:36:34.420 | And if the president were to do this, then the CDC could take it over and they could

00:36:38.460 | say, OK, it's on us.

00:36:40.300 | We're going to decide.

00:36:42.260 | The UK actually did this.

00:36:44.740 | Early on, they said, OK.

00:36:46.540 | They laid out a very clear regimen.

00:36:48.180 | They said, this is how we are going to evaluate rapid antigen tests because they're public

00:36:53.660 | health tools.

00:36:54.860 | They did it in a domain that was outside of their normal medical diagnostic regulatory

00:36:59.300 | agencies.

00:37:00.680 | And they literally just had a very fast screening to say, what are the best tests?

00:37:06.940 | They went through a huge number of different tests.

00:37:09.420 | They said, OK, this is the rank order of which tests are good, which are bad, which are scalable,

00:37:14.060 | which are not.

00:37:16.380 | And they were able to start deploying them in weeks, not years.

00:37:20.340 | So I think the CDC really needs to take charge.

00:37:22.820 | The problem is when it comes to law, if everyone currently perceives this as fully within the

00:37:30.140 | domain of the FDA and they've never heard of such a public health test idea enabling,

00:37:37.220 | but the FDA itself has created the idea by saying, we don't regulate public health tools.

00:37:43.120 | So the word is out there.

00:37:44.120 | The FDA has said, we don't regulate them.

00:37:47.100 | So that gives the president an opportunity to say, OK, these are those.

00:37:52.340 | These are public health tools by definition.

00:37:56.140 | And I do think that this is a kind of a crisis.

00:37:58.340 | And it's a crisis of testing.

00:37:59.540 | But it's also a crisis of like, really, we're going to go through this whole pandemic and

00:38:03.580 | never figure this thing out?

00:38:05.860 | That's just really sad.

00:38:07.380 | You know, if we get through this and don't figure out how to evaluate a damn rapid test.

00:38:12.540 | So how do vaccines play with this?

00:38:15.980 | So one of the things that when people discuss solutions to COVID, there's a sense that once

00:38:24.180 | you have a vaccine, COVID is solved.

00:38:26.620 | So how does that interplay?

00:38:29.100 | Why do we still need tests if we have vaccines?

00:38:31.860 | Yeah, I actually wrote an op-ed in New York Times or Wall Street Journal or something

00:38:37.660 | that was titled, Why We Still Need Rapid Tests With Vaccines.

00:38:42.860 | And the real reason is because we have evaluated our vaccines based on their ability to stop

00:38:49.740 | disease.

00:38:50.740 | In fact, most of the trials didn't evaluate them based on their ability to stop transmission.

00:38:56.820 | They didn't even evaluate that at all.

00:38:59.080 | No less put it as one of the metrics for authorization.

00:39:03.460 | And with a virus like this, it would be a bit naive to think that it's really going

00:39:08.340 | to stop transmission.

00:39:10.860 | Well, I think a lot of excitement happened right after the first clinical trials.

00:39:16.260 | And I'm sure we were talking about it when I was last here, I would imagine, given the

00:39:20.100 | timing.

00:39:21.340 | But those first clinical trials came out and everyone jumped for joy that these things

00:39:25.500 | were going to be the end to this pandemic.

00:39:28.840 | But we had really short-sighted vision there by not recognizing two main features.

00:39:34.600 | One is that they might not stop transmission.

00:39:38.580 | Another I guess three.

00:39:39.580 | Another is that new variants might come around that will break through the vaccine protective

00:39:43.960 | immunity.

00:39:45.200 | And the third is that we were measuring the efficacy of these vaccines during the peak

00:39:52.860 | of their performance in the first few months after people got vaccinated.

00:39:56.900 | And that gives a skewed view of just how effective these are going to be long term.

00:40:00.340 | So what happened with the vaccines is that everyone got very comfortable, including the

00:40:06.320 | CDC saying, if you've been vaccinated, you know, this is the end of the pandemic for

00:40:10.880 | you and let's keep it up.

00:40:14.020 | But then Delta comes along and waning immunity comes along and both of these things compound

00:40:18.580 | exactly as anticipated to get breakthrough cases.

00:40:23.100 | And unfortunately, what we're seeing now is the CDC and the administration went so all

00:40:28.920 | in on saying that breakthrough cases are rare, that transmission doesn't really happen if

00:40:34.280 | you're vaccinated without great data, especially with Delta, that once people started seeing

00:40:39.780 | breakthrough cases, they started interpreting that as a failure of the vaccine.

00:40:45.340 | The vaccines are still working to keep people out of the hospital for the most part, but

00:40:51.100 | they're not working to stop transmission.

00:40:53.700 | And if our goal is to stop transmission, which until we decide as a society that we have

00:41:00.220 | different goals, like we're okay with people getting ill and letting transmission go because

00:41:06.260 | we don't want to worry about it anymore.

00:41:08.420 | We're not there yet.

00:41:09.420 | So until we decide we're not going to stop transmission, we need other avenues besides

00:41:13.520 | the vaccine because it's not doing it.

00:41:16.540 | It also means that herd immunity isn't going to happen.

00:41:19.660 | And unfortunately, as long as we keep letting spread happen in the context of vaccinated

00:41:24.020 | people, we're kind of giving this virus a bootcamp of exactly what it needs to do and

00:41:30.540 | mutate to get around our vaccine-derived antibodies.

00:41:34.140 | That makes me very nervous.

00:41:35.280 | So the more we can do to stop spread in the unvaccinated, in the elderly vaccinated, and

00:41:40.980 | in other people, the better.

00:41:44.580 | We just should be focusing on that.

00:41:46.580 | - So in your eyes, the solution would look like this.

00:41:49.580 | You would make enough tests where every single person would get tested every single day?

00:41:54.700 | - I think that that would be, I don't want to do that actually.

00:41:58.020 | I want to do a variation on that.

00:42:00.300 | I think what we should do is have a dynamical testing program.

00:42:04.220 | It doesn't have to be complicated.

00:42:08.620 | It's every household has a box of tests in their cupboard.

00:42:12.740 | And if you haven't seen any cases in your community for a long time, stop testing.

00:42:17.420 | Do wastewater testing to see if there's any RNA coming back.

00:42:22.280 | If you start to see RNA in the wastewater that represents the virus and you're still

00:42:25.860 | wanting to stop outbreaks, you say, "Hey, you know those tests that are in your cupboards,

00:42:31.340 | households in this county, why doesn't each household or each person in each household

00:42:35.380 | use one test per week?"

00:42:37.980 | - Can you, sorry to just pause on that idea.

00:42:41.900 | That's really cool, the wastewater testing.

00:42:44.860 | That's the thing?

00:42:45.860 | So you can get a sense of how prevalent the virus is in a particular community by testing

00:42:50.860 | the wastewater?

00:42:52.460 | - That's exactly right.

00:42:53.460 | And so the viral load associated, the viral load that you can find in the community represents

00:43:00.300 | the prevalence of the virus in the community, which is really quite nice.

00:43:04.860 | That's a nice way to paint like a map of the intensity of the virus.

00:43:10.660 | Okay, so when it goes above a certain level, you can start doing much higher frequency

00:43:18.140 | testing in each household.

00:43:20.740 | - That's right.

00:43:21.740 | So I don't want people to be in testing purgatory.

00:43:23.980 | Like that's not what I want.

00:43:24.980 | I just want us to get through this damn pandemic.

00:43:28.160 | And so we can monitor the wastewater or any other methods.

00:43:32.380 | We can monitor the hospitals and the clinics.

00:43:34.540 | And if somebody does come in with COVID like symptoms, and then a few other people come

00:43:38.300 | in, you realize, okay, we got spread happening in our community.

00:43:42.260 | Send out a text message, put it on the news, put in the newspaper, whatever you need to

00:43:45.580 | do, tell people, tell families, use your test.

00:43:49.800 | And if the cases get worse, because you're just doing it once a week, that's not going

00:43:53.780 | to stop transmission, but it's going to enable you to identify where outbreaks are happening.

00:43:59.900 | If you start to find outbreaks in pockets, then the rule is simply, okay, let's squash

00:44:04.620 | the outbreak real fast.

00:44:05.860 | So everyone in that area in certain zip code or whatever it might be, test every two days,

00:44:10.940 | you know, for seven days or every day for seven days, and you'll get rid of the outbreak.

00:44:17.240 | We can do that.

00:44:18.640 | And if you've now gone again, you know, a week or two with no cases identified, stop

00:44:24.580 | the testing again.

00:44:26.060 | That's the nice thing that everything changes when people have the tests in their home.

00:44:30.940 | It becomes dynamic, it can become easy.

00:44:34.420 | Send a text message, take your test today.

00:44:36.580 | If some people don't do it, that's fine.

00:44:38.420 | The only goal is to get R below one and you stop the outbreak.

00:44:44.240 | People think it has to be near perfect.

00:44:45.860 | I always hear people say, "Oh, what if somebody doesn't use it?"

00:44:49.660 | Or, "What if somebody lies?"

00:44:51.580 | Well, you have 98% of people testing or even 50%, that's a whole lot better.

00:44:57.940 | And you know, another big difference that people I think oftentimes have a problem wrapping

00:45:02.220 | their head around, especially to an extent physicians who are used to really, like who

00:45:09.140 | are used to different kinds of metrics, is that all we have to do to completely stop

00:45:14.100 | an outbreak from spreading in a community is to get for every hundred infected people

00:45:20.980 | to get them to go on and infect 95.

00:45:24.620 | Most people would say, "Oh my God, that's a horrible program.

00:45:28.580 | You're still letting a hundred people go and infect 95 people."

00:45:32.380 | But for a virus like this, that's a massive public health win.

00:45:37.300 | If you can get a hundred people to infect 90, most people, doctors I would say, like

00:45:41.620 | a lot of people would say, "That sounds like a failure," to be honest.

00:45:45.500 | But if you do that for multiple days in a row, then in a couple of weeks you've gone

00:45:50.180 | from a big outbreak to a very, very small outbreak.

00:45:53.640 | And on the other hand, if you don't do that, if you allow a hundred people to just infect

00:45:57.140 | 140 people because you're not doing the testing, then instead of having 20 people at the end

00:46:03.660 | of those four weeks with the testing, you literally would have 600.

00:46:08.580 | Massive differences here.

00:46:10.220 | And the only goal then is to get R below one, have a hundred people infect less than a hundred

00:46:14.980 | and you stop the outbreaks and everyone stays safe.

00:46:18.460 | - From everything you've seen, how cheap can these things get?

00:46:21.740 | In the past year, in terms of the developments you've seen with the various test manufacturers,

00:46:27.300 | how cheap can it be to make a test, to manufacture a test?

00:46:31.980 | - So there's the manufacturing process, that could be 50 cents, maybe less.

00:46:36.660 | It's hard to really have eyeballs inside these companies in terms of where they're producing

00:46:41.340 | them in China and Taiwan, a number of other places.

00:46:46.460 | Some of them are produced here in the United States too, but 50 cents, say, was a very,

00:46:49.860 | very reasonable, generous number for how much it costs per test.

00:46:55.020 | You look at a place with high market competition that has actually authorized a lot of these

00:46:58.860 | tests like Germany.

00:46:59.860 | Germany has 60, 70 some odd different companies of high quality rapid tests authorized.

00:47:06.380 | You can go there and buy it for 80 cents, and they're still making a profit.

00:47:10.500 | And so it's extremely cheap.

00:47:13.260 | Market competition can drive these tests way down in terms of cost.

00:47:19.140 | I think one of the most important features of a rapid test program is what do you do

00:47:25.420 | with the result?

00:47:26.820 | Is it going to be used for you to gain entry to school or work?

00:47:32.020 | Is it going to be reported to the public health agencies?

00:47:35.900 | All of these, the primary mode should be just get people tests, but really if you're going

00:47:39.740 | to be using it for a workplace thing, like what Biden is now saying, vaccinator test,

00:47:44.300 | which is going to lead to a crisis if we don't fix this soon because we're going to have

00:47:47.500 | massive demand for testing in the next couple of weeks.

00:47:51.500 | But when he says that, that's essentially saying, okay, companies need to make sure

00:47:55.340 | that their people are testing.

00:47:57.220 | So are you going to base it on the honor system?

00:47:59.980 | I would say you probably would not base testing on the honor system if it's like to take somebody

00:48:07.100 | who would otherwise be quarantined in school and say, "You can go to school as long as

00:48:11.280 | your test is negative."

00:48:12.540 | So test to stay program is a big thing that I've been pushing for and others have.

00:48:17.660 | Businesses bringing people into work who need to test, they need to have verification, but

00:48:24.100 | they don't want to set up nursing stations in their lobbies or in the school parking

00:48:28.180 | lot or whatever.

00:48:29.180 | Everyone's tired of that.

00:48:30.300 | We need to bring the test into the home, but that means we need the technology to enable

00:48:34.820 | it.

00:48:36.300 | So I was at a conference recently.

00:48:38.020 | Do you know Mike Milken, Milken Institute?

00:48:41.260 | He's a very wealthy billionaire, but he's done a lot of philanthropy and he hosts a

00:48:45.980 | conference to raise money for prostate cancer research.

00:48:49.700 | I was at this conference recently, Francis Collins, a number of other people were there.

00:48:56.020 | And every morning, we all had to test in the morning, which I thought was a great idea

00:48:59.780 | obviously before we walked into that conference.

00:49:04.860 | But you didn't have to test there and they didn't base it on the honor system.

00:49:07.980 | Every morning, I scanned a QR code on the box and eMed, which is a service that provides

00:49:16.180 | test verification, popped up with a proctor right on my phone or on my computer and said,

00:49:22.740 | "Okay, let's go through your tests."

00:49:24.900 | And they watch you, they videotape you using the test, so it's all recorded.

00:49:27.900 | It's all a reportable type of test.

00:49:31.260 | And at the end of it, just from your home, you don't actually see the proctor, but they're

00:49:36.300 | just verifying that you actually do it.

00:49:38.540 | They verify the test, they verify the test results with you.

00:49:42.900 | And at the end of it, you've then gotten from your couch or from your car, wherever you

00:49:47.500 | are, an actual verified laboratory report that can be considered proof that you yourself

00:49:54.180 | used the test and you yourself got a negative.

00:49:56.900 | So the tools are out here if we want to use them at scale.

00:50:00.540 | In fact, the CDC uses eMed now to enable people to come back into the United States through

00:50:07.460 | an antigen test.

00:50:08.460 | So before you get on your flight, you're sitting in the airport in Heathrow or wherever you

00:50:11.340 | are, you can get on your computer, use your eMed test, and you get the negative and CDC

00:50:17.860 | will accept that.

00:50:18.860 | TSA will accept you to come back into the US with a rapid antigen test that you did

00:50:22.660 | without anyone else watching, except for this proctor on your phone.

00:50:26.380 | Super simple.

00:50:28.060 | How much private information is being collected?

00:50:30.540 | So like, people have, in the United States, the American way, they have a hesitancy on

00:50:37.940 | the overreach of government in things like vaccine passports.

00:50:43.700 | Like using any mechanism, any mechanism of verification that's controlled by government

00:50:50.820 | can lead to overreach by said government.

00:50:54.460 | So there's a concern of that.

00:50:55.980 | Do you see there a way of achieving testing that's verified but does not violate people's

00:51:02.980 | privacy or sense of freedom?

00:51:05.420 | Absolutely.

00:51:06.420 | I think so.

00:51:07.780 | The way that right now in the United States, they're requesting that these tests get, that

00:51:15.500 | the results get delivered to public health agencies.

00:51:18.580 | But I've long held that while that's ideal, it should never be the thing that holds up

00:51:23.780 | somebody being allowed to know their own status.

00:51:27.500 | But if you are going to work and you have to let your boss or your manager, whomever,

00:51:33.140 | know that you were negative that day, or if you're going to school, I think it's going

00:51:37.140 | to be hard to maintain complete privacy in that situation because they need to know your

00:51:44.460 | name.

00:51:45.460 | But sure, I mean, could you cut off the public health reporting?

00:51:48.740 | Yes, you could.

00:51:50.260 | But I worry, I mean, can you opt out?

00:51:52.420 | Maybe you could opt out.

00:51:53.900 | That should be a feature.

00:51:55.260 | I want to opt out of the public health reporting because, for whatever reason, otherwise I'm

00:52:01.020 | not going to do the test.

00:52:02.860 | But that means that, okay, then you're not going to go to work.

00:52:04.980 | So right now there's this serious tension and I am very uncomfortable with the idea

00:52:10.700 | that we force anyone to do anything.

00:52:13.180 | But there is a tension between these two things for sure.

00:52:16.740 | And how do you balance that during a public health emergency?

00:52:21.380 | I think first and foremost, let people, everyone has a right to know their status.

00:52:26.700 | The fact that we have made it hard for people to know their status on their terms, I think

00:52:31.020 | is a travesty.

00:52:32.020 | I mean, it's just so terrible that we have prioritized us knowing at the expense of you.

00:52:41.940 | Essentially what public health has long said during this pandemic is, if I'm public health,

00:52:46.940 | if I can't know, then you can't know your status.

00:52:50.140 | That's not the right way to look at public health.

00:52:51.940 | We need to engage the public.

00:52:54.540 | And if some of them don't want to participate in the public health part but want to know

00:52:58.540 | their status, by default they are participating in public health whether they know it or not

00:53:03.260 | because they're not going to go get their mom sick by mistake.

00:53:05.900 | At least most people wouldn't.

00:53:07.940 | And also you can create systems where individuals can form relationships based on their status

00:53:18.060 | without ever reporting it to a centralized place.

00:53:21.500 | So you can go to, I don't know, a local business owner might require that you show that you

00:53:29.060 | are negative, but that doesn't require reporting it.

00:53:32.620 | You can, like there might be basically like an ID that's only in possession.

00:53:40.580 | You are the only person in possession of that.

00:53:42.380 | So you literally show it.

00:53:44.260 | Here's a test I took.

00:53:45.620 | It's negative.

00:53:46.660 | Nobody else knows about that test.

00:53:48.300 | So that could very well be done even through a company like E-Med.

00:53:52.140 | I think, and I might be wrong here, I believe that they take the test result and because

00:53:58.660 | they are considered a CLIA waived laboratory, like a digital laboratory, they report their

00:54:04.360 | results by law out to the public health agencies.

00:54:08.860 | But let's say there was something a little different.

00:54:10.420 | Let's say you were verifying an over-the-counter test and it doesn't have to be a CLIA waived

00:54:14.540 | because it's over-the-counter.

00:54:15.540 | Then you're not bound by CLIA rules and you could create the same service, but that just

00:54:21.460 | doesn't report out to the public health agencies.

00:54:23.860 | It gives people the option to opt in or out of public health reporting.

00:54:28.140 | And I know that public health people get a little queasy when I talk about this, but

00:54:36.580 | as a public health person myself, like yes, of course I would prefer that the data be

00:54:40.220 | available to evaluate, to know where the cases are.

00:54:43.780 | But first and foremost, I want to make sure that the people using the test are going to

00:54:49.380 | use the test.

00:54:50.380 | And if that means that they're not reporting and that's the only way that they will use

00:54:54.420 | it is if it's not reported, then that's better than no test.

00:54:58.740 | Especially given that the central to the vaccine hesitancy is a distrust of authority and the

00:55:05.380 | distrust of government.

00:55:07.140 | So you're asking people to get tested and report their status to a centralized authority

00:55:18.380 | when they're clearly do not trust that authority.

00:55:21.700 | It doesn't make any sense.

00:55:22.980 | It seems like a perfect solution to let people who are hesitant on a vaccine to get their

00:55:30.220 | own status and have full control of that information and opt in, provide that information if they

00:55:35.060 | wish to, but they have the full control of it and have the freedom to do that information

00:55:39.180 | what they want.

00:55:40.460 | - I fully agree with that.

00:55:42.060 | I really do.

00:55:43.060 | I think we can have the verified services and we could have the privacy if you want it.

00:55:47.780 | If you need to go into a restaurant and there's a rule that you have to be a negative test,

00:55:53.100 | have it on your phone and only your phone.

00:55:54.860 | And it's okay.

00:55:55.860 | Like email emails you the lab report.

00:55:58.180 | You have it.

00:55:59.180 | You can say, look, that's my name.

00:56:00.180 | I used it this morning.

00:56:01.900 | Negative.

00:56:03.180 | And in that case, you'd want something that just is there and is not going anywhere else.

00:56:07.620 | And I think that those services, like I think they can exist and it's a struggle because

00:56:13.580 | for those companies, they don't want to fall out of favor with the CDC or with the FDA.

00:56:20.020 | And so this is a big problem in our marketplace in general, by having private companies who

00:56:28.260 | want to be the public health agents of this pandemic, we lose a lot of control because

00:56:35.500 | the companies ultimately have to do what's going to make them money so they survive and

00:56:39.580 | keep performing the service.

00:56:40.940 | It's really just such a hard problem.

00:56:44.700 | And this is why last time I was here, I'm guessing I was probably really pushing for

00:56:49.900 | the government to be producing these tests.

00:56:53.660 | I think I would have still been pushing for that.

00:56:55.460 | At this point, I've decided, okay, government's clearly not going to do that.

00:56:59.220 | I've been thinking I really want Elon Musk to produce the tests.

00:57:03.140 | I really am sort of serious that these tests are simple to make, but we've been using machines

00:57:10.320 | to make them that have been around for a long time.

00:57:13.140 | Scale is an issue right now, kind of.

00:57:16.100 | Really it's the EUA process and getting the companies to be allowed to market in the US

00:57:19.940 | that's the issue.

00:57:20.940 | But let's just say scale is the issue.

00:57:23.260 | And one company wants to make 20 million tests a day.

00:57:27.340 | These aren't that hard.

00:57:28.700 | We should be able to do that.

00:57:29.780 | We just need a faster machine, a better machine, and a quicker one.

00:57:33.420 | And there's a few folks, like you mentioned, know how to solve that problem.

00:57:36.580 | I've had a lot of discussion with Tesla folks and with people that used to work at Tesla,

00:57:41.940 | like Jim Keller, about how to make stuff much cheaper, much better.

00:57:45.860 | That's basically what Tesla is world-class at.

00:57:48.140 | And it's like, okay, does this thing have to cost $1,000?

00:57:53.580 | No, it can cost $10.

00:57:55.860 | And let's figure out how to manufacture it.

00:57:58.740 | Those folks are like the best in the world at doing that.

00:58:01.700 | But what about this Biden action plan?

00:58:06.540 | So it sounds like the guy agrees with you, vaccinate or test.

00:58:12.580 | So I think given that choice, a lot of people go with test in America, because there's like

00:58:18.940 | a division it seems like.

00:58:20.860 | So what, is this just politics?

00:58:23.340 | Is this just words?

00:58:24.900 | Or do you think this is actually going to lead to something?

00:58:27.460 | And maybe can you explain what the action plan is?

00:58:31.820 | - So there's a number of pillars to the action plan.

00:58:36.220 | The two that I've been most focused on, I mean, some of them are we want to get everyone

00:58:39.500 | vaccinated, all these things.

00:58:41.300 | And one pillar is saying any company in the United States that has more than 100 employees

00:58:51.780 | is now required to ensure that any unvaccinated individuals in their workforce test weekly.

00:59:01.500 | Another pillar is that the president's going to reduce the cost of PCR tests by 35%, which

00:59:09.780 | is pretty moderate reduction, and is going to reduce the cost of antigen tests and scale

00:59:18.620 | them up and make 280 million tests and put $2 billion into it.

00:59:26.540 | So those are the two that I found most intriguing for the kind of mission that I've been on,

00:59:30.220 | which is to just educate people around, hey, we have really, really powerful public health

00:59:34.820 | tools we have yet to deploy.

00:59:39.660 | The issue at hand, though, is that now that the president has said vaccinate or test,

00:59:47.660 | there's a problem inherent in that.

00:59:49.380 | It's essentially to coerce people who are unvaccinated to get vaccinated, because vaccinate

00:59:54.500 | or test doesn't make sense when the vaccinated people can transmit the virus just fine.

00:59:57.900 | - It should be vaccinate and test.

01:00:00.180 | - Exactly.

01:00:01.180 | The problem that I have with that vaccinate or test idea is it's great if you want to

01:00:05.660 | use it as a coercive effort to get people vaccinated.

01:00:10.780 | Like I'm not going to wade into that argument.

01:00:13.700 | Do I agree with it or not?

01:00:14.740 | I'm just not going to even put my words under it.

01:00:17.900 | - I disagree with it.

01:00:19.340 | Let me say that.

01:00:20.500 | I disagree.

01:00:21.500 | As opposed to doing great science communication, this weird, like people talking down to the

01:00:28.820 | populace as if they're children trying to trick them.

01:00:31.580 | Here, have some candy.

01:00:34.300 | Everyone with common sense.

01:00:37.020 | Somebody told me, I was having a conversation, like if the government is going to give you

01:00:41.660 | money to take the vaccine, people that were already hesitant about the vaccine are not

01:00:48.020 | going to trust whatever the heck you're doing.

01:00:50.580 | So don't trick people into taking the vaccine.

01:00:53.000 | Be honest and communicate transparently everything that's known about the vaccine.

01:00:57.860 | Communicate the data, inspire people with transparency and like real communication of

01:01:08.140 | all the uncertainty around it and all the difficult decisions of risk and all those

01:01:12.540 | kinds of things.

01:01:13.540 | And as opposed to trying to trick them like children into taking the vaccine anyway.

01:01:18.500 | Yes, but-

01:01:19.740 | - Okay, well, I didn't have to say it.

01:01:22.500 | So there we go.

01:01:24.340 | - But you're saying it should not be like vaccinate or test.

01:01:28.540 | That trade off does not make sense.

01:01:29.540 | - Exactly.

01:01:30.540 | Vaccinate, by saying vaccinate or test is absolutely confusing because it implies for

01:01:37.380 | anyone who's thinking about it, it is implying, and I've seen this because I have business

01:01:41.260 | leaders call me, Fortune 500 business leaders who call me and say, "What do I do?

01:01:45.900 | Like I have 8,000 employees, where am I going to get my tests?"

01:01:48.620 | And a lot of people are saying they're calling this a pandemic of the unvaccinated.

01:01:54.900 | These types of divisive, this divisive language doesn't help.

01:01:59.620 | This isn't a pandemic of the unvaccinated.

01:02:01.340 | This is a pandemic of a fucking virus.

01:02:05.580 | Don't ever put it on the unvaccinated who frankly are just scared.

01:02:08.700 | They don't know who to trust.

01:02:11.180 | And we haven't given them a lot of reason to trust public health, to be frank.

01:02:16.820 | So I agree.

01:02:17.820 | I mean, now that you've opened the door, I'll just say my piece.

01:02:21.220 | Like absolutely, we need to be the most honest we can with all of this.

01:02:26.700 | This is confusing language to say vaccinate or test.

01:02:28.820 | We need to say, we need to be very upfront and say, "Look, vaccines aren't stopping transmission

01:02:35.500 | very well.

01:02:36.980 | Unfortunately, this is the world we have.

01:02:39.100 | We have Delta, we're going to have new mutants.

01:02:41.540 | We have a vaccine that wanes somewhat over time.

01:02:45.140 | This is biology.

01:02:46.140 | I'm sorry.

01:02:47.140 | You know, this is just what it is."

01:02:50.020 | And then we say, "But the vaccines are really protective for your personal health.

01:02:54.540 | They're going to keep you out of the hospital.

01:02:56.000 | This is what you should care about as an individual."

01:02:59.180 | And as a population, we need to figure out, "Okay, we have to stop transmission if that's

01:03:03.980 | our goal."

01:03:05.900 | So we should use the tools that are going to stop transmission if that's our goal.

01:03:09.140 | And saying vaccinate or test, if our goal is to actually stop transmission, that's confusing

01:03:14.020 | because vaccines are not stopping it, they're maybe mildly lowering the risk of transmission.

01:03:21.180 | So I'm just not a fan of that language.

01:03:23.420 | I think we should be being very, very clear, like you said, and upfront about what are

01:03:26.860 | the limitations of the test, of the vaccine and of the test.

01:03:31.460 | And we should be very clear that like, you know, it can only help.

01:03:34.780 | The American public in aggregate is extremely intelligent.

01:03:39.740 | They will figure out when you say that vaccine breakthrough cases are rare, and then they

01:03:44.860 | start seeing story after story of like whole parties of people who are vaccinated have

01:03:49.380 | outbreaks and everyone knows more people now who are having breakthrough cases than they

01:03:54.100 | knew who had regular cases before the vaccine.

01:03:57.420 | People start to wonder, "Hmm, well, this is weird.

01:04:00.900 | They say that the vaccines are working, breakthrough cases are rare.

01:04:03.400 | Maybe the whole vaccine program is failing entirely."

01:04:06.380 | And so it ends up shooting ourselves in the foot if we try to create false expectations

01:04:11.700 | because we think it's going to be beneficial for one thing when it's not for the other.

01:04:16.900 | And so to get back to the action plan, vaccinate or test, I think, and the increase in rapid

01:04:25.100 | tests, I do think it was a bold move.

01:04:27.340 | I think it, I would say that it was the most prominent sort of display, encouraging display

01:04:34.520 | of the fact that rapid tests are indeed effective public health tools.

01:04:40.900 | My real concern now with, is that 280 million tests, that's like less than one per person

01:04:46.540 | per year in the United States.

01:04:47.860 | So that's not the way that he said and delivered it.

01:04:51.820 | And what most people think of when they hear the word 280 million, you don't usually put

01:04:55.460 | a lot of thought into what does that number mean?

01:04:57.100 | It sounds a big number.

01:04:59.340 | Most people are now going to be expecting that these tests are actually going to be

01:05:02.820 | staying in stock on the shelves at CVS and Walgreens and Amazon or whatever.

01:05:08.220 | So that's crisis number one is like, now the expectation is set for having rapid tests,

01:05:13.580 | but they're not going to scale that well.

01:05:15.860 | We won't have them.

01:05:16.860 | And then there's vaccinate or test.

01:05:19.540 | And that's going to bring millions and millions of people who are not currently testing to

01:05:23.780 | have to start testing.

01:05:24.780 | So that's going to overwhelm our PCR labs.

01:05:27.700 | And it's going to create five day delays again with PCR, if not longer, because we'll have

01:05:32.380 | backlogs.

01:05:34.140 | And so the only real solution to this is to just scale up the tests that are actually

01:05:38.020 | scalable.

01:05:39.360 | And that's the simple rapid tests.

01:05:40.740 | And it's not even to scale them up through production and manufacturing here.

01:05:45.380 | It's to open the door so that the companies that already exist here and can scale are

01:05:49.660 | allowed to do it and to bring in the international market.

01:05:52.620 | Some of the biggest diagnostic companies in the world are not selling their millions and

01:05:58.300 | millions and billions of tests in the United States, because they don't want to play the

01:06:04.540 | game that the FDA is currently requiring of them.

01:06:08.100 | So we have an opportunity.

01:06:09.660 | And I am very encouraged that the president actually did put these into the action plan.

01:06:13.460 | And I do want to say for the record that I'm supportive of it in principle.

01:06:18.760 | But I think now we actually are in the time where has been set and we have to deal with

01:06:25.100 | the crisis before it happens.

01:06:26.700 | Otherwise, there could be some real political points taken off.

01:06:30.300 | I do worry that the president, if he doesn't pull through with this and really make the

01:06:35.180 | tests available, and we end up getting into this other test crisis this fall, there could

01:06:39.580 | be political consequences to that.

01:06:41.500 | And the reason is like these rapid tests are so personal, they become emotional almost.

01:06:46.620 | They give people that empowerment that I was talking about earlier.

01:06:50.140 | And when people can't get that because the shelves are out of stock, they actually feel

01:06:55.820 | frustrated and then that converts into like anger, like in the blame.

01:07:00.380 | And so I do think that we have to be really smart about making a policy like this and

01:07:05.140 | then ensuring that we can carry through with what the average American is actually expecting.

01:07:11.580 | And speaking of politics, one of the great things about testing, maybe you can correct

01:07:16.740 | me, but for my sense, it's one of the only solutions to COVID that has not yet been politicized.

01:07:23.700 | So masks and vaccines, whether you like it or not, have been heavily politicized where

01:07:30.340 | there's literally a red-blue split on the use of those, or like proud use, effective

01:07:40.140 | use of those tools.

01:07:42.380 | And it seems like everybody I talk to about testing, everybody's on board, red or blue.

01:07:47.860 | - They are, which is why I am particularly concerned about the vaccinate or test policy.

01:07:53.260 | - Right.

01:07:54.260 | - Because all of a sudden we just politicized it.

01:07:56.300 | We just brought it with this thing that was fully bipartisan, really bipartisan.

01:08:02.780 | I mean, I've talked to the really right side of Congress and the super liberal side of

01:08:09.660 | Congress, the Senate, the same politicians, governors everywhere in this country have

01:08:16.020 | asked me for support around these rapid tests because it just, you can have a reported or

01:08:21.900 | not.

01:08:22.900 | You can have a home in the privacy of your own home or not, or you do it at school.

01:08:27.140 | These tools are just so powerful to identify infectious people.

01:08:30.780 | They didn't have to be politicized.

01:08:32.980 | They still don't.

01:08:33.980 | I don't think that the action plan went so far that it's going to politicize them, but

01:08:37.940 | I do think already it's starting to conjure up emotion saying, "Well, now I have to get

01:08:43.380 | tested."

01:08:44.380 | - The have to part, right.

01:08:45.380 | - And that is where we go wrong.

01:08:48.220 | I have to get tested or vaccinated.

01:08:52.620 | Through that, I am independent, whatever.

01:08:57.460 | And I do worry that this thing that was purely bipartisan, that we could have just scaled

01:09:02.260 | up months ago.

01:09:03.500 | People would have, we could have delivered it to every household, didn't even have to

01:09:06.380 | ask people to request it, just delivered packages to every home in America by now easily.

01:09:13.340 | If we were smart about it, we could have done it.

01:09:16.140 | - The most unpleasant thing about COVID is the uncertainty.

01:09:19.660 | And that's what leads to fear on both the vaccine hesitant, it's the uncertainty about

01:09:25.660 | the vaccine and people who have taken the vaccine, the uncertainty around like, "Am

01:09:32.940 | I in danger walking around?

01:09:34.740 | Can I go, can I walk down the hall?"

01:09:36.900 | Like this fear of the world around you.

01:09:39.060 | And I think testing allows you to remove a lot of that uncertainty.

01:09:45.300 | You gain back confidence that you can operate in this world and not get infected.

01:09:49.820 | And you become like a nicer person.

01:09:52.420 | I find myself every time I get tested, I become a nicer person to others.

01:09:56.820 | 'Cause I know I'm not putting people in danger.

01:10:02.220 | - It's a heavy burden to carry to worry.

01:10:05.820 | Am I infectious?

01:10:06.820 | Like I was out last night, but I do wanna go see my mom today.

01:10:09.740 | Like, am I infectious?

01:10:11.300 | I don't know.

01:10:12.300 | And this has created massive anxiety.

01:10:15.260 | I can't, I completely agree that it's a relieving feeling.

01:10:22.460 | And it's an amazing feeling to be in a room when, and I did this in the middle of the

01:10:27.100 | pandemic when everyone was supposed to be wearing a mask indoors and everyone rapid

01:10:32.340 | tests.

01:10:33.340 | And I said, "Everyone should rapid test before you walk into this room."

01:10:38.180 | And it was a wonderful experiment because everyone was just so relaxed.

01:10:44.820 | The alternative is everyone, nobody tests and everyone wears a mask.

01:10:49.500 | You have a mask that maybe gives you 20% maybe protection during, if you're all in the same

01:10:55.660 | room together, if that, or you have a rapid test program where everyone rapid tests before

01:11:00.740 | and that gives you like 95% to 100% protection, not 100%, but close.

01:11:07.380 | And all of a sudden that allows everyone to take a big sigh and be like, "Wow, this is

01:11:11.140 | the first time I've seen people without masks indoors in a long time and I feel pretty good."

01:11:16.140 | And restaurants, like restaurants are scary right now because you just don't know who

01:11:20.300 | might be infectious and nobody's masked.

01:11:24.580 | And like, wouldn't it be great to just go into a restaurant where you know that everyone

01:11:29.100 | just tested negative that day?

01:11:31.700 | Just really reduces anxiety.

01:11:34.680 | It makes individuals feel empowered.

01:11:37.860 | And I mean, at the end of the day, COVID and our response to COVID, it's truly an information

01:11:43.220 | problem.

01:11:45.380 | Why do we quarantine anyone?

01:11:46.800 | Why did we ever close anything down?

01:11:48.260 | We didn't close things down because everyone is positive.

01:11:51.200 | We closed things down because we didn't know if anyone was positive.

01:11:55.340 | We quarantine a whole classroom of kids, not because they're all positive, but because

01:12:00.260 | we don't know if one of them are positive.

01:12:02.260 | And so we just quarantine everyone.

01:12:04.220 | When there's a positive in the classroom, like one day, we'll then ask the whole classroom

01:12:08.780 | not to come to school for 10 days.

01:12:11.540 | That's not a biological problem.

01:12:14.220 | That's an information problem.

01:12:16.460 | And the crazy thing is we have the tool to solve that information problem.

01:12:21.600 | It's literally our eyes on the virus.

01:12:23.300 | It's how we see this virus.

01:12:24.620 | And if everyone glowed green when they were infectious, we would have never had to close

01:12:28.300 | down any society and we would have never had the outbreaks because we would have been able

01:12:32.340 | to stay away from the green people.

01:12:35.780 | I like what you said, the quarantine is an information problem.

01:12:38.300 | That's absolutely right.

01:12:39.940 | Is there something you can say to what people can do, like listening to this, individuals?

01:12:45.100 | Do you just complain loudly, like why can't we do this?

01:12:50.540 | Can you speak with your money somehow?

01:12:53.500 | What can people do to help?

01:12:57.260 | It's amazing to think you're asking me this question and this video will go out to the

01:13:02.740 | web and all the people that watch you.

01:13:05.900 | And last year in July, maybe, something like that, June, I forget exactly when it was,

01:13:11.060 | I was on Twiv this week in virology.

01:13:13.420 | Shout out to Twiv.

01:13:15.500 | Those guys are awesome.

01:13:16.500 | They are awesome.

01:13:17.500 | I love Twiv.

01:13:19.740 | And they asked me the exact same question towards the end.

01:13:22.300 | They said, "This makes so much sense.

01:13:23.700 | Why wouldn't we do this?

01:13:24.980 | What can people do?"

01:13:26.060 | And so I said, "Oh, just send me an email.

01:13:29.740 | Write to me.

01:13:30.740 | I'm sure you could find my email somewhere online and get in touch and we can try to

01:13:36.580 | figure out how to make something happen."

01:13:39.420 | Bad idea.

01:13:40.420 | Yeah, that was smart.

01:13:41.420 | Very smart.

01:13:42.420 | Way too many emails.

01:13:44.740 | I feel bad because I didn't end up getting back to anyone because I just got inundated.

01:13:48.760 | But it did lead to the development of rapidtest.org where we did automate the process of writing

01:13:54.660 | letters to congressional members and elected representatives.

01:14:00.600 | So that helps.

01:14:02.460 | Fast forward to today.

01:14:04.060 | What can people do?

01:14:07.060 | I honestly don't know.

01:14:08.980 | What can the average person at this point do?

01:14:10.900 | We have tried everything.

01:14:13.140 | The FDA is immutable on this.

01:14:15.340 | They will not change and we shouldn't ask them to change because they have decided that

01:14:20.020 | this is how they regulate medical devices and they're going to stick to it.

01:14:23.260 | So what we need to do, and maybe this is something you do, is get, if you know people who have

01:14:30.460 | sway over politicians, lobbyists, whatever it might be, let people know to request that

01:14:36.740 | the president, literally the president of the United States, uses executive powers to

01:14:43.880 | just do something as simple as designating these powerful public health tools as public

01:14:50.060 | health tools.

01:14:51.100 | Allow the CDC and the NIH or whomever it must be or academic centers of excellence designated

01:14:57.980 | by the CDC to evaluate the tests in a very fast fashion with the appropriate metrics

01:15:05.180 | that these tests need to achieve for public health.

01:15:08.100 | And within two days, we can have 10 new tests authorized.

01:15:12.740 | You know, this doesn't have to be a six to 12 month endeavor.

01:15:15.240 | This could be a two day endeavor.

01:15:17.020 | We actually did it.

01:15:18.020 | I judged the rapid test X price and it went great.

01:15:22.340 | We actually got incredible metrics about how well does each test work and no clinical trials,

01:15:28.740 | you know, just a couple days worth of work in the lab and boom.

01:15:31.940 | And if we actually systematize it, it would be an hour or so in the lab.

01:15:35.180 | You know, so simple.

01:15:38.100 | So I don't know.

01:15:39.100 | I mean, I don't know how to really impact change.

01:15:41.620 | I've thankfully, you know, I have a platform and I've been able to start talking with people

01:15:47.180 | who are very close to the president and the White House.

01:15:50.660 | And and I do think that some change is finally happening because the silver bullet of the

01:15:56.780 | vaccine has not panned out to be the silver bullets.

01:15:59.740 | And now we got to now I think we're moving from a country that was a vaccine only approach

01:16:05.260 | to finally recognizing at the highest levels that there's other tools.

01:16:10.500 | Do you think it's possible to reopen fully without solving the testing problem completely?

01:16:15.780 | Like, do you think this vaccine approach will get us to reopen fully?

01:16:21.380 | I do.

01:16:22.380 | Yeah, I think over time, though.

01:16:24.940 | I mean, if we a lot of people ask me, like, what's what's like happening?

01:16:29.940 | Like, what's the end game here?

01:16:31.540 | Like, where does this end?

01:16:33.980 | And it's actually not a mystery.

01:16:37.940 | The end game is we will grow out of this virus.

01:16:43.380 | And by that, I mean, you and I and most people who are watching this are adults, right?

01:16:51.540 | Adults don't like to get infected with a virus for the very first time as adults.

01:16:56.940 | Babies are okay with it.

01:16:58.660 | And so what we have to do to understand how we're getting out of this virus is to look

01:17:03.940 | at babies like a newborns and say, okay, how does a baby get out of their high risk time

01:17:09.340 | period?

01:17:10.340 | They get exposed, they get like exposed multiple times or vaccinated, of course.

01:17:15.420 | And eventually, they get exposed enough that they build up this nice cushion of immunity

01:17:19.540 | that's sufficiently diverse, that they can battle whatever gets thrown at them because

01:17:23.460 | they've seen it already.

01:17:25.860 | But one exposure doesn't do it.

01:17:28.340 | I mean, over the course of the first few years of life, kids get exposed to coronaviruses

01:17:32.820 | tons of times, lots of different viruses they get.

01:17:35.840 | So unfortunately, what's happening with us, why this is so bad for us is that as we're

01:17:40.260 | adults, we don't regenerate tissue very well.

01:17:43.200 | We have like overabundant inflammatory response.

01:17:45.100 | We have all these problems that when we get an infection for the first time, it sucks,

01:17:49.940 | it harms us, it causes us problems.

01:17:52.300 | But over time, just like a baby, we're going to start building up our immunity through

01:17:56.760 | vaccines and exposures.

01:17:58.260 | You know, I hate to say it, but tons of people are getting exposed to Delta right now who

01:18:03.140 | don't know it.

01:18:05.220 | It's a disease that's known to kill millions.

01:18:07.860 | If you're vaccinated, you don't know it, is my point there.

01:18:11.580 | And at the end of the day, this is actually, I do not want this to be misconstrued as like

01:18:16.300 | saying go get infected.

01:18:18.380 | But the fact that people are getting infected will add to our level of protection later

01:18:23.100 | on.

01:18:24.100 | >> Leven: Yeah, but the question is how long that whole process takes.

01:18:27.100 | >> Christopher: I think, my guess is probably by the end of next year, early 2023, we will

01:18:33.260 | probably start looking at this as though it is not a particularly dangerous virus for

01:18:37.820 | most people.

01:18:38.820 | The elderly though, it will still be, but that's because their immunity--

01:18:41.700 | >> Leven: With variants and stuff.

01:18:42.700 | >> Christopher: Well, right, that's the--

01:18:43.700 | >> Leven: I've heard other people say this statement you just said a year ago about this

01:18:48.300 | spring, right?

01:18:49.300 | >> Christopher: Well, that probably was not wise.

01:18:51.500 | >> Leven: Well, I mean, it's because the intuition is like, okay, now that there's a vaccine,

01:18:58.060 | you're either going to take the vaccine or get infected, and then there'll be herd immunity

01:19:01.580 | over, like it'll be very quick.

01:19:03.900 | So that's the intuition, but it seems like that's not happening.

01:19:10.180 | It seems like we're in this constant state of fear-mongering for different reasons.

01:19:16.660 | It's almost like the virus got deeply integrated not into just our biology, but in the game

01:19:25.620 | of politics and in the fear-mongering around the news, because the virus now started being

01:19:32.260 | together with the vaccine and the masks, and it started getting integrated into the division

01:19:40.020 | that's so effective at monetizing social media, for example.

01:19:45.220 | And so it's like, all right, so how do you get out of that?

01:19:50.340 | Because you can always kind of present certain kinds of numbers about number of cases or

01:19:54.140 | how full hospitals are and start making claims about that we're still, this is as bad as

01:20:02.300 | it's ever been, those kinds of statements.

01:20:04.980 | And so I'm not sure exactly what the way out is, except the same way out as it was originally,

01:20:10.940 | which is testing, is information.

01:20:14.140 | It's information.

01:20:15.140 | >> Joe: Yeah, and I think we can do that.

01:20:17.540 | We can keep outbreaks suppressed with testing, because it's information.

01:20:21.700 | Like people keep thinking of tests as being medical things.

01:20:23.980 | They're not.

01:20:24.980 | They're information.

01:20:25.980 | It can allow us to control things, just like we drive down a road and we look at the cars

01:20:32.700 | and we don't hit other cars because we have the information out there in the lane next

01:20:36.020 | to us, and they're moving over.

01:20:38.780 | That's just information.

01:20:39.780 | >> Luke: Like you said, glow green.

01:20:41.400 | The problem with the virus, you don't see.

01:20:44.100 | You're walking around and everybody's a potential infectious creature.

01:20:51.860 | And so if you see the world as a potential for infection, you're going to be terrified

01:20:56.700 | of that world.

01:20:57.700 | >> Joe: That's exactly right.

01:20:58.700 | And that is what has happened.

01:20:59.700 | And that's why I've been pushing so hard for these tests, because they can allow people,

01:21:05.100 | if you use them at a community level, you can have enough people know that they're positive,

01:21:08.980 | enough people are good people that they won't go out and infect others.

01:21:12.660 | And the other great thing about them is, again, a 10-day isolation period, especially for

01:21:18.020 | a vaccinated person, but in either case, is also an information problem.

01:21:23.860 | We don't have to isolate for 10 days if we're infected.

01:21:26.920 | What if we're only infectious for two?

01:21:29.420 | Especially if we're vaccinated.

01:21:30.420 | Why are we telling people the only reason the CDC ever and the WHO ever suggested a

01:21:34.100 | 10-day isolation or a 14-day quarantine is because we didn't know when people stopped

01:21:39.540 | being infectious.

01:21:41.460 | There's actually some people stay infectious for 14 days.

01:21:44.020 | It's rare.

01:21:45.020 | But there's a lot of people who stay infectious for like four.

01:21:48.580 | And that's a whole nother week that we're asking people to isolate.

01:21:51.540 | People would probably be much more likely to comply if they only had to isolate as long

01:21:56.460 | as they wake up each morning and see two lines.

01:21:59.100 | Because you're actually seeing it for your own two eyes.

01:22:00.940 | You're being empowered to make your own decision.

01:22:03.620 | You're not being told, "You need to isolate for 10 days."

01:22:06.340 | And you're sitting there thinking, "Oh, I feel fine.

01:22:08.140 | I don't know why."

01:22:09.140 | You know, there's a lot of asymptomatic spread.

01:22:11.020 | But if you see the two lines every day, then you're doing a little experiment for yourself

01:22:17.820 | to prove to yourself, "Today I'm still infectious.

01:22:21.420 | Let's hope it's tomorrow.

01:22:22.420 | Come on, immune system.

01:22:23.420 | You can do this."

01:22:24.800 | And then you get to day four and boom, you start being negative.

01:22:28.500 | That's a much more tolerable thing because you are being able to make that decision based

01:22:33.680 | on true data that is empowering you.

01:22:37.100 | And it really does change, changes everything.

01:22:40.540 | Because it's all fear and empowerment.

01:22:44.100 | And these are empowering devices.

01:22:46.020 | - Well, I wanted to have this conversation with you because obviously it's a great solution.

01:22:51.100 | Let's keep talking about it.

01:22:52.500 | People who listen to this should, I guess, pressure local politicians, federal, national

01:22:59.780 | politicians.

01:23:00.780 | - Write articles.

01:23:01.780 | Write articles with the title like, "Dear POTUS."

01:23:06.380 | Please designate these as public health tools or just start talking about it in the media.

01:23:10.500 | Talk about it on social media, anywhere.

01:23:12.580 | Testing is a public health good.

01:23:15.020 | Testing is a public health good.

01:23:16.100 | We all, like it should not be considered a medical device.

01:23:21.420 | I shouldn't have to pay to keep you safe.

01:23:24.780 | Like testing should generally be free for that matter, like subsidized by the government.

01:23:29.760 | These tools exist.

01:23:31.260 | We should all, and I think the more people that generate noise to just say a public health

01:23:36.940 | test is a public health tool.

01:23:38.820 | Period.

01:23:39.820 | You can't even argue with it.

01:23:43.100 | - Yeah, I think if you talk about it enough, then certain people that have even a bigger

01:23:48.740 | platform like Elon Musk, Sunder Pichai, those folks that have power to really do large-scale

01:23:57.620 | manufacturing also influence governments will pay attention.

01:24:03.020 | That's the hope.

01:24:04.020 | Enough people talk about it.

01:24:05.020 | - I think business leaders, like business leaders obviously have so much power here.

01:24:11.740 | They pay the lobbyists to make things happen.

01:24:14.380 | Let's be honest, there's people who pull levers that are not the politicians themselves.

01:24:17.820 | I do think business leaders have so much to gain from these tools to keep their businesses

01:24:23.140 | safe to not have to quarantine and lock down.

01:24:25.900 | I hope that all of them hear this message to say let's ask the president or the people

01:24:31.540 | around the president to designate these as public health tools.

01:24:36.300 | Change the system.

01:24:37.300 | If you can't change every aspect of the system, then figure out how to change the system enough

01:24:42.060 | so that you're doing everything in a safe way that is not endangering anyone but is

01:24:47.380 | only protective.

01:24:50.780 | - You mentioned last time that you spent time as a Buddhist monk.

01:24:55.220 | We didn't spend much time talking about it.

01:24:57.980 | I just would love to talk to you about it a little bit more.

01:25:02.660 | Maybe by way of advice, how do you recommend people can integrate meditation into their

01:25:09.260 | lives or how does one meditate?

01:25:14.540 | - I think for me meditation was really an active effort, which sounds weird because

01:25:25.620 | most people think of meditation as like the absence of activity.

01:25:31.260 | But just like anything, meditation requires exercise.

01:25:36.780 | In this case, it requires exercise and quieting your mind.

01:25:40.700 | And the whole, well, there's a lot of different reasons people meditate.

01:25:45.740 | Most people watching this podcast or this show, what is this called?

01:25:50.300 | - I don't know.

01:25:51.300 | - Is this an interview?

01:25:52.300 | - I'm not even recording.

01:25:53.300 | This is just you and I talking.

01:25:56.660 | - It is.

01:25:58.300 | Most people are meditating to bring some balance and bring some sanity to their life and just

01:26:04.340 | like be able to control their feelings and emotions a little bit more.

01:26:09.180 | And for that purpose, I think the best way to, what meditation is, if you can call it

01:26:15.620 | what you will, it's just getting some alone time, some time to think or not think, whatever.

01:26:20.860 | And it looks different for each person.

01:26:23.220 | For me, it was a very active effort to try to quiet my mind with the explicit intent

01:26:30.540 | to detach from things, from lots of things.

01:26:34.980 | And it's actually, it sounds weird in our culture here to talk about detachment as a

01:26:40.460 | goal, detachment from loved ones, detachment from objects is kind of easy to reconcile.

01:26:47.340 | People understand that, yeah, I don't wanna be too attached to my car or whatever.

01:26:51.460 | But detachment from a loved one is like a very hard thing 'cause we wanna do the opposite

01:26:55.340 | usually.

01:26:56.340 | We wanna love a loved one.

01:26:58.900 | But in a lot of Buddhist thought, it is those attachments that keep people in this cycle

01:27:05.780 | of rebirth.

01:27:06.780 | Now, I don't personally believe in rebirth in a Buddhist sense in that you actually get

01:27:18.420 | born multiple times.

01:27:19.740 | I think my personal feeling is we die and we're vanished.

01:27:25.340 | That's just me.

01:27:28.640 | But I still really found meditation to be extraordinarily powerful to feel control over

01:27:36.540 | a whole different part of my body that I never thought that it could be controlled, your

01:27:42.060 | mind.

01:27:43.060 | Like you close your eyes and most of us immediately start seeing watches and we start thinking

01:27:50.380 | about things.

01:27:52.980 | And it's an amazing feeling to start getting to the point where you can actually quiet

01:27:59.840 | your mind and close your mind down so that you can just have peace, like silence of your

01:28:07.960 | mind for a long period of time.

01:28:09.840 | And I loved it.

01:28:11.720 | It was, but it's kind of a dangerous slope because you can kind of get caught up in it

01:28:15.960 | and like really start going from, "Okay, I'm trying to quiet my mind to almost being like

01:28:20.600 | addicted to quieting your mind."

01:28:22.940 | And it was a very active exercise every day, 15 hours a day to just practice quieting my

01:28:28.400 | mind and eventually I could.

01:28:32.800 | And in Buddhism, there's a whole lot of stages that you go through to once you hit that point

01:28:37.880 | where you can quiet your mind, then there's like other psychological things that happen.

01:28:43.400 | And eventually the end goal for a Buddhist monk who's spending their life meditating

01:28:50.040 | in the forest is to achieve nirvana, is to have an absence of any attachment to the point

01:28:56.800 | where you're not even attached to your own foot or your own leg.

01:29:01.240 | You can cut it off and say, "Well, that was-"

01:29:04.600 | - So you don't even have an attachment to self, like to ego, to, do you feel like a

01:29:09.760 | conscious being or no?

01:29:11.120 | Like the goal?

01:29:12.120 | - Well, I never attained it, but I didn't really.

01:29:14.120 | - Is that the goal, to escape?

01:29:15.920 | - So the goal is you have to first look at it through the eyes of samsara, which is the

01:29:21.160 | cycle of rebirth, which is suffering.

01:29:24.040 | It's a cycle of suffering is how it's viewed.

01:29:26.280 | And the idea is like, if I really love this hat and then the hat gets lost, I'm sad.

01:29:32.340 | So that makes me suffer.

01:29:34.840 | And if I hate this hat and I see it, then it makes me sad or mad and that it's an emotion.

01:29:40.340 | But if I'm completely ambivalent about that hat, I don't care if it's there, I don't care

01:29:45.760 | if it gets lost, if it's shredded, then that invokes no emotional rise out of me, good

01:29:52.400 | or bad.

01:29:53.400 | And so the idea is to find the balance there where you are so detached from everything

01:29:57.920 | that you're not getting a rise, negative or positive.

01:30:01.680 | And this is really, it's really such a distinct thing in a relative to our normal lives here

01:30:11.600 | in America, where we live for rises.

01:30:15.080 | You want happiness and joy.

01:30:17.120 | And then you also, nobody wants sadness, but when you come out of sadness, you feel happy.

01:30:23.320 | Either way it averages out.

01:30:24.920 | And if it doesn't average out, then you're in a bad spot.

01:30:29.040 | That would be things like major depressive disorder where you're truly not averaging

01:30:32.920 | out.

01:30:33.920 | But if you're living a pretty happy life, that's why there's no right or wrong.

01:30:36.620 | You can go up and down and you average out or you can just go that straight line.

01:30:40.760 | - So this is not necessarily the Buddhist idealism, how obviously the ideal you should

01:30:48.440 | strive for, but the actual exercise and meditation that the Buddhist monks use seems like a great

01:30:59.320 | tool for becoming aware of your own mind.

01:31:04.440 | And that seems to be important for appreciating life or some kind of experiencing life on

01:31:13.480 | a deeper level.

01:31:16.240 | - I think so.

01:31:17.240 | I mean, that's my personal opinion is yes.

01:31:20.680 | And that I think it, I don't meditate anymore.

01:31:26.000 | - Back in the capitalist Western world where there's meetings and--

01:31:31.040 | - That's right.

01:31:32.040 | - I was a monk and then the tsunami hit and I lived in a refugee camp and that was the

01:31:38.120 | Indian Ocean tsunami in 2004.

01:31:41.080 | And it just really, it was really interesting in Sri Lanka.

01:31:46.160 | They wanted me, I asked, "Well, what can I do to help?"

01:31:49.800 | It was a horrible, horrible hell on earth experience in many ways.

01:31:56.040 | But when I said, "What can I do to help?"

01:31:59.320 | The answer was, "Well, you could meditate.

01:32:02.160 | That's how, keep doing what you're doing.

01:32:06.360 | That's how we can get good karma."

01:32:07.920 | And to me coming from Western roots, I just couldn't deal with that.

01:32:11.880 | I just said that it doesn't make sense to me.

01:32:14.760 | Why would I just sit and meditate when there's so much devastation happening here?

01:32:20.280 | And so I kind of stopped meditating then and then never really recovered from that time

01:32:24.400 | in the refugee camp.

01:32:26.080 | But I do feel like I understand or like I am aware of a part of me that most people

01:32:33.120 | never get the privilege to be aware of.

01:32:35.280 | And that is a pretty profound and it's a profound feeling I think or just awareness to say,

01:32:43.280 | "Oh, I do have the, if I ever need to go back to that, I have the capacity to do that."

01:32:49.040 | And I do use it.

01:32:50.040 | I mean, I don't use it a lot, but I use it when I really need to, to try to settle myself,

01:32:57.960 | to actually calm myself, whether it's pain, physical or emotional pain.

01:33:04.720 | It is possible to make those things go away, but just like anything, it takes training.

01:33:13.200 | If you take yourself back to that place you were, Sam Harris talks about that through

01:33:20.160 | his meditation practice, he's able to escape the sense of free will and the sense of agency.

01:33:28.960 | You can get away from that.

01:33:30.960 | Do you ever think about consciousness and free will when you were meditating?

01:33:36.640 | Like did you get some deep insight about the nature of consciousness that you were somehow

01:33:43.800 | able to escape it through meditation or no?

01:33:47.320 | I looked at it in a much more utilitarian way, I think.

01:33:52.640 | The sensation, like minimizing amount of thoughts in your mind and then beginning to really

01:33:57.040 | appreciate the sensation.

01:33:59.800 | You weren't writing a book on free will.

01:34:03.800 | Maybe if I kept at it, there's a good chance that if the tsunami didn't happen, I might

01:34:08.800 | still be sitting there on the top of that mountain.

01:34:10.800 | The tsunami is you see pain, you see, especially if you see cruelty and you're supposed to

01:34:18.360 | meditate through that, that doesn't, there's something in the human spirit that pushes

01:34:24.200 | us to want to help.

01:34:25.920 | If you see somebody who's suffering, to react to that seems like to help them as opposed

01:34:30.760 | to care less through meditation.

01:34:35.080 | Don't become attached to the suffering of others.

01:34:37.760 | Exactly.

01:34:38.760 | I mean, that's, I do think that that's, you know, and they're two totally valid ways to

01:34:43.440 | live life.

01:34:45.320 | They are generally, I think they're ingrained in us pretty early in society.

01:34:50.080 | Right, and it's hard to escape.

01:34:52.920 | What about just in general, becoming detached from possessions like minimalism and not having

01:35:00.320 | many things.

01:35:01.760 | So the capitalist world kind of pushes you towards having possessions and deriving joy

01:35:10.280 | from more and more and better possessions.

01:35:12.880 | Have you, have you returned back to the joys of that world or do you find yourself enjoying

01:35:20.240 | the minimalist life?

01:35:22.720 | A little of both.

01:35:23.720 | I think I really don't like, I find things to be a burden, to be a massive burden.

01:35:33.800 | And to me when you have a burden like that, you know, even if it's just knowing that there's

01:35:37.680 | like boxes in your basement of stuff, you know, whatever it might be, it makes it hard

01:35:43.280 | to focus.

01:35:46.200 | And so I personally like, I mean, my ideal, like if I had a, my house for example, would

01:35:53.080 | be to have like nothing on anything.

01:35:58.240 | And that to me is like peaceful.

01:36:00.720 | Some people find that to be not peaceful.

01:36:03.600 | For me it's like, I love to have the idea that if needed I could like pack up and move

01:36:12.840 | and not worry about anything.

01:36:15.280 | Do I actually have that in reality?

01:36:17.640 | No.

01:36:18.640 | I mean, we're about to have a baby, you know, there's, but it's like, it's already, I already

01:36:23.560 | see it.

01:36:24.560 | It's like stressful.

01:36:25.560 | There's like boxes of stuff showing up at the house, like bottles and clothes and all

01:36:30.480 | these little hats and whatnot.

01:36:31.880 | And I do, I do have to like sometimes go into my meditation to just, just say like, this

01:36:39.280 | is okay.

01:36:40.280 | You know, like it's okay to have all of this stuff.

01:36:46.240 | It's not permanent, you know, and, but I do think that it's easy to get lost in it all.

01:36:52.440 | - And it's important to remember, given all that, like people who buy houses, you know,

01:36:56.880 | buy a home and buy a house and make a home out of it.

01:36:59.880 | And you start a family.

01:37:01.760 | It's easy to forget that even though you have all these responsibilities, you're still free.

01:37:08.480 | And like freedom takes work and it takes remembering, it takes meditation on it, but you're free.

01:37:16.160 | You're, you're born free, you live free.

01:37:18.080 | I mean, depends of course, which country, but in the United States, even with all the

01:37:21.600 | possessions, even with all the burdens of sort of credit and owing money and all those

01:37:29.920 | kinds of things, you can scale everything down and you're free.

01:37:35.200 | But ultimately the people you love, you love each other.

01:37:39.400 | It doesn't take much money to be happy together.

01:37:43.160 | And for me, I personally value that freedom of having the freedom to always pursue your

01:37:48.440 | happiness as opposed to being burdened by material possessions that, you know, yeah,

01:37:55.840 | that basically limit your ability to be happy.

01:37:58.240 | Cause you're always paying off stuff.

01:38:00.040 | You're always catching, you know, trying to match the neighbors that are always a little

01:38:03.800 | bit richer, that kind of pursuit.

01:38:05.880 | I think that pursuit is wonderful for innovation and for building cooler, better things, but

01:38:11.440 | on an individual level, I think you have to remember that first of all, life is finite.

01:38:17.360 | And second of all, like your goal is not to get a bigger house.

01:38:20.240 | Your goal is to be just content and happy in the moment.

01:38:24.800 | - I completely, completely agree with that.

01:38:28.260 | - So in looking at our failure at scale to, to engineer, to manufacture, to deploy tests,

01:38:39.840 | how do you feel about our prospect as a human civilization?

01:38:43.080 | Are you optimistic?

01:38:45.240 | So this pandemic, it is what it is.

01:38:49.640 | It hurt a lot of people, both it took lives, but it also hurt a lot of businesses and a

01:38:57.440 | lot of people economically.

01:39:00.800 | But they're very likely to be a much worse pandemic down the line.

01:39:05.080 | There might be other threats to human civilization.

01:39:08.040 | Are you nevertheless optimistic?

01:39:10.080 | - Oh, I don't think I'm optimistic about it at all.

01:39:14.600 | - What are you most worried about?

01:39:17.560 | - It's one of those things that's so existential that I don't worry about it.

01:39:22.440 | But I do think, I mean, let's, in the United States, for example, so you asked about the

01:39:26.600 | human civilization, but let's talk about like American society for a moment.

01:39:31.640 | I do think that like, we're probably seeing like the end of a really interesting experiment,

01:39:38.480 | like the American experiment, and we're seeing its limitations.

01:39:42.460 | We're probably going to become another blip, like another one, another power that's in

01:39:46.320 | the history books that like rose and collapsed.

01:39:48.680 | Probably that's where we'll go.

01:39:51.040 | In terms of civilization, I think we're demonstrating a pretty significant inability to recognize

01:40:00.160 | the danger wherein, whether that's the pandemic or whether that's climate change.

01:40:06.520 | I think it's extraordinary that we are not taking these things seriously, and we're not

01:40:15.040 | acting with the urgency.

01:40:16.720 | And I mean, in some ways, climate change truly makes like this pandemic look like child's

01:40:23.200 | play in terms of like the destruction it has the potential to wreak.

01:40:28.640 | I tend to think if you just look at the progress of human history, that the people who do good

01:40:35.920 | in the world outpower the people that do bad in the world.

01:40:42.080 | So we kind of, there's something about our minds that likes to focus on the negative,

01:40:47.920 | like on the destructive, because we're afraid of it.

01:40:52.240 | It's also for some reason more fun to watch destruction.

01:40:56.960 | But it seems like the people who build, who create solutions, who innovate and who just

01:41:06.080 | put like both on the emotional level, so love out there and like on the actual engineering

01:41:13.440 | level tools that make for higher quality of life.

01:41:16.520 | I think those win out if you look at human history.

01:41:20.320 | But the question is whether the negative stuff can sometimes peak to the level where everybody's

01:41:25.360 | just destroyed.

01:41:26.680 | But as long as that doesn't happen, I tend to believe that there'll be like a gradual

01:41:32.520 | with some noise, a gradual improvement of quality of life in human civilization.

01:41:38.320 | - I do think so to a certain extent, but it's that what you said, like, unless there's like

01:41:43.160 | some significant peak of bad, you know, the problem with bad is that it can happen like

01:41:50.680 | that, you know, good.

01:41:53.200 | You can't build a society overnight, but you sure can kill one.

01:41:57.800 | Like I just think about food crises and instability and just, I don't know, but I do hope that,

01:42:05.400 | I mean, I completely agree.

01:42:06.400 | I think we can engineer our way to a healthier, better world.

01:42:12.840 | Like I truly do.

01:42:15.560 | My concern is that the people who are doing that until very recently don't generally rule

01:42:21.040 | the world.

01:42:22.760 | Now of course we're seeing non-elected leaders and, you know, people who run massive corporations

01:42:31.560 | essentially having as much or really more power than elected leaders or than kings and

01:42:38.320 | queens and such.

01:42:40.120 | So how they choose to wield that power, you know, is an interesting choice.

01:42:43.920 | And I do hope that you're right in that over time, fear will drive companies to produce

01:42:53.480 | a better product or whatever, you know, something like over time, it's just like predator and

01:42:57.480 | prey models.

01:42:59.440 | You get so bad or so everything like it's so revved up that all of a sudden something

01:43:04.160 | cracks and they say, "Okay, I do want an electric car," or whatever.

01:43:09.080 | And that takes some combination of innovation, letting people know that these electric cars

01:43:13.520 | exist.

01:43:14.520 | It's kind of like rapid test too.

01:43:15.520 | You're like, you get to finally feel it and see it, have an electric car, and then all

01:43:20.240 | of a sudden things change and everyone says, "Oh, this is so bad," and actually I'm doing

01:43:23.640 | good for the world relatively speaking.

01:43:25.840 | And, you know, I guess that's--

01:43:27.640 | - It's a paradigm shift.

01:43:28.640 | - Yeah.

01:43:29.640 | - It becomes, for lack of a better word, viral.

01:43:33.200 | - Yes.

01:43:34.200 | - Positivity does.

01:43:35.200 | And I mean, I believe that ultimately that wins out because I think there's much more

01:43:41.920 | power to be gained.

01:43:44.080 | So I think most people wanna do good and if you want to wield power, you want to channel

01:43:52.000 | people's desire to do good.

01:43:54.480 | And I think over time, that's exactly what people will do.

01:43:59.520 | But yeah, I mean, both on the natural side, the pandemic, you know, there's still biology

01:44:04.240 | at play.

01:44:05.240 | There's still viruses out there trying to kill us.

01:44:07.240 | There's accidents, there's nuclear weapons, there's unintended consequences of tools,

01:44:12.360 | whether it's on the nanotechnology side or the artificial intelligence side.

01:44:17.000 | Then there's the natural things like meteors and all that kind of stuff.

01:44:21.160 | And the climate change, all of that.

01:44:25.400 | But I tend to think we humans are a clever bunch.

01:44:28.800 | And when there's a deadline, a real deadline, or a real threat before us, we kind of step

01:44:34.400 | up.

01:44:35.400 | I don't know, but maybe you have to believe that until the very end.

01:44:41.600 | Otherwise life is not as fun.

01:44:45.280 | That's right.

01:44:46.280 | I mean, we'll have to see, I guess.

01:44:48.880 | Well, ideally we won't be alive to see that.

01:44:51.880 | Well, no, Michael, I'm glad we talk again because this has been such a difficult time

01:45:00.800 | that feels like there's no solutions.

01:45:05.240 | But it's so refreshing to hear that there's a solution to COVID.

01:45:10.400 | And there's an engineering solution on the individual level, something people can do.

01:45:14.960 | On the government level, it's something people can do.

01:45:17.600 | On the global level, it's something people can do.

01:45:20.200 | We should be doing rapid testing at scale.

01:45:23.320 | It's obvious.

01:45:24.760 | It's amazing that you still are telling that story, pushing that message bravely, boldly.

01:45:33.720 | I really, really appreciate the work you're doing, man.

01:45:36.120 | And I will do in my small way the same to try to help out, and everybody else should

01:45:42.840 | too, until we get hundreds of millions of tests in people's hands.

01:45:48.000 | It's an obvious solution.

01:45:49.000 | We should have had it a long time ago.

01:45:51.720 | And I like solutions, not problems.

01:45:57.040 | And this is obviously a solution.

01:45:58.760 | So thank you for presenting it to the world, and thank you for talking about it.

01:46:02.760 | It's something that I can't not do.

01:46:05.960 | If it saves one person's life, then it was worth the two years of lobbying for this.

01:46:11.800 | So let's hope we see a change.

01:46:15.120 | Thanks for talking today.

01:46:17.120 | Absolutely.

01:46:18.120 | Thanks for listening to this conversation with Michael Mina.

01:46:21.240 | To support this podcast, please check out our sponsors in the description.

01:46:25.640 | And now, let me leave you with some words from Lord Byron.

01:46:30.360 | Always laugh when you can.

01:46:32.280 | It is cheap medicine.

01:46:35.160 | Thank you for listening, and hope to see you next time.

01:46:37.840 | Bye.

01:46:38.840 | Bye.

01:46:39.840 | Bye.

01:46:40.840 | Bye.

01:46:41.840 | Bye.

01:46:41.840 | [BLANK_AUDIO]

Michael Mina: Rapid COVID Testing | Lex Fridman Podcast #235

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