back to index

Improving Health With Stronger Brain-Body Connection | Huberman Lab Essentials


Chapters

0:0 Sense of Self, Interoception
1:25 Brain & Body Communication, Vagus Nerve, Mechanical & Chemical Information
4:43 Lungs & Diaphragm, Tool: Breathwork for Alert or Calm
9:47 Brain & Gut Communication, Tool: Reduce Sugar Cravings
15:0 Brain, Gut Chemistry, Inflammation & Gut Microbiome, Tool: Fermented Foods
18:53 Vomiting, Brain; Tool: Reduce Nausea
23:52 Fever, Brain Chemistry, Tool: Cooling Body
28:20 Vagus Nerve, Emotions, Mood, Tool: Heart Awareness
34:29 Recap & Key Takeaways

Whisper Transcript | Transcript Only Page

00:00:00.000 | Welcome to Huberman Lab Essentials,
00:00:02.260 | where we revisit past episodes
00:00:04.080 | for the most potent and actionable science-based tools
00:00:07.260 | for mental health, physical health, and performance.
00:00:09.960 | I'm Andrew Huberman,
00:00:12.680 | and I'm a professor of neurobiology and ophthalmology
00:00:15.280 | at Stanford School of Medicine.
00:00:16.740 | Today, we are going to talk about our sense of self,
00:00:20.140 | or what's called interoception.
00:00:21.880 | Interoception is our sensing of our internal landscape,
00:00:26.140 | things like our heartbeat, our breathing,
00:00:29.020 | and our gut.
00:00:30.400 | This discussion about sense of self and interoception
00:00:33.320 | has many important actionable items
00:00:35.780 | that relate to bodily health and brain health.
00:00:38.560 | Of all the topics I could cover,
00:00:40.440 | this thing that we call sense of self,
00:00:42.640 | which is also called interoception,
00:00:44.560 | has perhaps the most foundational level of importance
00:00:48.460 | for all that we feel, all that we do,
00:00:51.700 | and all that we are capable of doing.
00:00:53.660 | And I promise that if you can learn a little bit
00:00:57.000 | about the mechanisms of self-sensing,
00:00:59.320 | of understanding what's going on in your internal milieu,
00:01:03.040 | as we say, your internal environment,
00:01:04.820 | you will position yourself to do some very simple things
00:01:08.840 | that can lead to outsized positive effects
00:01:11.300 | on everything from sleep,
00:01:12.840 | to body composition,
00:01:15.440 | to mental focus,
00:01:16.620 | to mood,
00:01:17.320 | your ability to regulate stress,
00:01:19.660 | and indeed, even your ability to heal and recovery
00:01:22.200 | from injuries of different kinds,
00:01:23.620 | brain injury and bodily injury.
00:01:25.100 | We have a system in our body
00:01:27.320 | that connects our brain to all of our bodily organs
00:01:30.900 | and connects all of those bodily organs to our brain.
00:01:34.660 | And that communication between brain and body
00:01:37.260 | in both directions creates a situation
00:01:41.080 | where either we are positioned to do things well,
00:01:43.800 | or we are positioned to do things poorly.
00:01:45.900 | So I really want to dive in and dissect
00:01:48.660 | what is this system of brain-body communication?
00:01:50.920 | What does it look like?
00:01:51.720 | What are the actual neurons and connections?
00:01:53.600 | The system that's most often associated with this
00:01:56.040 | is our 10th cranial nerve called the vagus nerve.
00:01:59.800 | The word vagus relates to the word vagabond,
00:02:03.060 | which is to wander.
00:02:04.080 | And indeed, the vagus nerve is a vast,
00:02:07.360 | enormous wandering set of nerves.
00:02:10.200 | So it's not one nerve.
00:02:11.200 | It's not like one fiber, one axon, as we say.
00:02:13.760 | So where do they go?
00:02:14.640 | Well, they leave the brain and the brain stem.
00:02:18.880 | The brain stem is kind of the back of your brain.
00:02:20.560 | If you touch the back of your neck,
00:02:21.820 | it's about three inches deep to where you're touching.
00:02:24.220 | The neurons that are there
00:02:26.440 | send information into the body
00:02:29.420 | to control your bodily organs.
00:02:31.180 | How fast your heart is beating,
00:02:33.400 | how fast you're breathing,
00:02:34.640 | how fast your digestion is occurring.
00:02:36.740 | Even things like whether or not
00:02:38.760 | you are going to secrete so-called killer cells,
00:02:41.440 | your immune cells from your spleen
00:02:43.620 | to go ward off bacteria.
00:02:45.360 | Now the neurons there don't know what to do
00:02:48.500 | unless they receive information
00:02:50.180 | about what's going on within the body.
00:02:52.100 | So everything from your intestines
00:02:53.680 | to your stomach, et cetera,
00:02:55.100 | and your spleen are sending information
00:02:57.260 | also up to the brain.
00:02:59.040 | There are two fundamental features
00:03:01.500 | of what's going on in your body
00:03:03.320 | that need to be communicated to your brain,
00:03:06.020 | these neurons in your brain stem,
00:03:07.500 | in order for your brain and your body
00:03:09.500 | to work together correctly.
00:03:10.920 | And the two types of information
00:03:13.000 | are mechanical information
00:03:14.800 | and chemical information.
00:03:17.380 | So when you think about your sense of self
00:03:19.460 | and your ability to understand
00:03:21.120 | what's going on in your body,
00:03:22.280 | if you feel good or if you feel bad,
00:03:24.040 | your sense of self is dependent
00:03:25.980 | on these mechanical phenomenon
00:03:28.100 | and these chemical phenomenon.
00:03:30.160 | If your gut is full or empty,
00:03:33.140 | whether or not your heart is beating fast
00:03:35.700 | or beating slowly,
00:03:36.560 | that's mechanical.
00:03:38.040 | And chemical information,
00:03:39.380 | whether or not your gut feels nice
00:03:41.040 | and whether, you know,
00:03:41.920 | when I say nice,
00:03:42.800 | I mean whether or not it has a balance
00:03:44.300 | of acidity and alkalinity
00:03:46.460 | that feels right to you
00:03:47.700 | or whether or not your gut feels off,
00:03:49.460 | it doesn't feel quite right.
00:03:50.800 | That's chemical information.
00:03:52.640 | So the first principle
00:03:54.560 | that everyone should understand
00:03:56.600 | about their sense of self
00:03:57.980 | is that they are sensing mechanical
00:04:00.360 | and chemical information
00:04:01.640 | about every organ in their body,
00:04:03.500 | except for one
00:04:05.280 | and that's the brain.
00:04:06.700 | Your brain actually
00:04:07.920 | doesn't have pain receptors.
00:04:09.740 | It doesn't even have touch receptors.
00:04:11.260 | The brain is a command center.
00:04:13.120 | It helps drive
00:04:14.620 | and govern changes
00:04:15.580 | in the organs of the body.
00:04:16.720 | So your organs are different.
00:04:18.860 | They need to tell your brain
00:04:20.080 | what's going on
00:04:20.920 | and there are ways
00:04:21.980 | that you can control
00:04:23.220 | the mechanical
00:04:24.840 | and the chemical state
00:04:26.380 | of your organs
00:04:27.520 | in ways that are very powerful.
00:04:29.260 | So let's talk about
00:04:31.420 | how you can adjust
00:04:32.360 | the mechanical
00:04:33.080 | and chemical environment
00:04:34.260 | of your organs
00:04:35.260 | in order to make
00:04:36.280 | your brain better
00:04:36.980 | and how your brain
00:04:38.160 | can make the mechanical
00:04:39.540 | and chemical environment
00:04:41.180 | within your organs
00:04:42.140 | function better.
00:04:42.860 | Let's take one example
00:04:45.480 | of these
00:04:46.280 | and explain how mechanical
00:04:47.800 | and chemical information
00:04:49.140 | from this particular set
00:04:51.220 | of organs
00:04:51.780 | communicates to the brain
00:04:53.800 | and how that changes
00:04:54.820 | how our brain works.
00:04:55.860 | And the organ
00:04:57.200 | I'd like to focus on first
00:04:58.380 | are the lungs
00:04:59.760 | and the diaphragm.
00:05:01.060 | So we're all familiar
00:05:02.100 | with our lungs.
00:05:02.620 | these two big bags of air
00:05:03.940 | but they're actually
00:05:04.360 | not two big bags of air.
00:05:05.280 | They actually have
00:05:05.800 | little tiny sacks
00:05:07.200 | within them.
00:05:07.680 | Actually millions
00:05:08.440 | of little sacks
00:05:09.180 | called the aveoli
00:05:10.160 | of the lungs.
00:05:10.880 | The aveoli,
00:05:11.960 | the lungs are like
00:05:12.740 | little tiny balloons
00:05:13.740 | throughout our lungs.
00:05:14.700 | Those little bags of air
00:05:15.960 | can fill up
00:05:16.620 | or they can deflate,
00:05:17.800 | right?
00:05:18.460 | Just like your lungs
00:05:19.400 | overall can fill up
00:05:20.460 | or they can deflate.
00:05:21.300 | The diaphragm is a muscle
00:05:23.320 | and it sits below our lungs
00:05:24.820 | and the way the diaphragm
00:05:26.820 | and the lungs work together
00:05:27.740 | is very interesting.
00:05:28.500 | The diaphragm is actually
00:05:29.660 | skeletal muscle.
00:05:30.740 | So it's just like a bicep
00:05:31.860 | or a quadricep
00:05:32.740 | and the fact that it is
00:05:33.860 | skeletal muscle is important
00:05:35.100 | because it has a unique property
00:05:37.880 | which is that you can
00:05:38.760 | control it voluntarily.
00:05:40.320 | How the diaphragm moves up
00:05:41.900 | and down
00:05:42.440 | determines how you breathe.
00:05:43.840 | How you breathe
00:05:44.660 | is also dependent
00:05:45.340 | on little muscles
00:05:46.200 | that are between your ribs,
00:05:47.360 | the intercostals
00:05:49.400 | and other muscles.
00:05:50.320 | When we inhale,
00:05:51.500 | these little sacks
00:05:53.180 | in our lungs fill up
00:05:54.280 | and our lungs expand
00:05:56.100 | and when we do that,
00:05:57.760 | we take up space
00:05:58.720 | in our thoracic cavity
00:06:00.440 | and our diaphragm moves down.
00:06:03.820 | Okay?
00:06:04.540 | When we exhale,
00:06:06.040 | the diaphragm moves up,
00:06:07.520 | the lungs get smaller.
00:06:09.100 | Okay?
00:06:09.620 | This actually controls
00:06:10.960 | our heart rate
00:06:11.980 | and it works
00:06:12.480 | in the following way.
00:06:13.480 | Our heart actually
00:06:14.600 | has a little more space
00:06:15.760 | because the diaphragms move down
00:06:17.320 | so the heart gets
00:06:18.620 | a little bit bigger,
00:06:19.440 | physically bigger,
00:06:20.280 | not in the emotional sense,
00:06:21.420 | but physically bigger
00:06:22.660 | and as a consequence,
00:06:24.360 | whatever blood is in the heart
00:06:26.140 | flows at a slower rate
00:06:28.380 | because it's a larger volume.
00:06:30.460 | So bigger volume heart,
00:06:31.780 | same amount of blood
00:06:33.600 | inside the heart
00:06:34.220 | means slower flow.
00:06:35.680 | The brain registers that
00:06:37.440 | because there are a set
00:06:38.180 | of neurons on the heart
00:06:39.000 | called the sinoatrial node.
00:06:40.600 | That information
00:06:41.520 | is registered by the brain
00:06:43.040 | and the brain sends
00:06:43.900 | a message back to the heart
00:06:45.400 | to speed the heart up.
00:06:47.220 | So if you do long inhales
00:06:49.780 | or you inhale more vigorously,
00:06:51.780 | you actually are speeding
00:06:53.100 | your heart up.
00:06:53.980 | Now, of course,
00:06:55.340 | you have to exhale as well.
00:06:56.900 | But for instance,
00:06:57.900 | if I were to inhale very long,
00:06:59.340 | like the entire time
00:07:02.020 | my heart rate is increasing
00:07:03.080 | and then if I did a quick exhale,
00:07:04.560 | something else will happen.
00:07:06.780 | But if I kept doing that,
00:07:08.080 | my heart rate would increase.
00:07:12.360 | It's not going to increase
00:07:13.260 | linearly and forever,
00:07:14.420 | but it will increase
00:07:15.460 | with each inhale.
00:07:16.640 | or I can simply make
00:07:18.340 | my inhales more vigorous
00:07:19.540 | and my heart rate
00:07:21.200 | will speed up.
00:07:21.880 | This is an autonomic
00:07:23.300 | and automatic relationship
00:07:25.280 | between the diaphragm,
00:07:27.000 | the lungs,
00:07:27.480 | the brain and the heart.
00:07:28.900 | Now, if inhales speed the heart up,
00:07:31.280 | what happens on exhales?
00:07:32.300 | When we exhale,
00:07:33.300 | the diaphragm moves up.
00:07:35.900 | The heart has less space,
00:07:38.200 | meaning it gets
00:07:39.460 | a little bit smaller,
00:07:40.420 | which means that
00:07:41.520 | whatever volume of blood
00:07:42.540 | is inside the heart
00:07:43.360 | moves faster
00:07:44.520 | through that smaller volume.
00:07:45.820 | That information
00:07:47.520 | is sent to the brain
00:07:48.680 | via these collection
00:07:50.100 | of neurons
00:07:50.560 | called the sinoatrial node.
00:07:52.100 | The brain then sends information
00:07:54.400 | via the vagus nerve
00:07:55.820 | back to the heart
00:07:57.280 | to slow the heart down.
00:07:59.580 | So while inhales
00:08:01.360 | speed up the heart,
00:08:02.880 | exhales slow the heart down.
00:08:05.220 | And you can leverage this
00:08:06.360 | in a very powerful way
00:08:07.440 | to set the conditions
00:08:08.400 | of your mind.
00:08:09.200 | If you want to be more calm,
00:08:12.500 | emphasize exhales.
00:08:14.180 | And the simplest way
00:08:14.980 | to do this
00:08:15.400 | is to emphasize exhales
00:08:16.640 | through what's called
00:08:18.040 | a physiological sigh.
00:08:19.600 | Two inhales
00:08:21.000 | followed by a long exhale.
00:08:23.360 | Those double inhales
00:08:26.880 | are kind of important
00:08:27.700 | because what they do
00:08:28.480 | is they maximally fill
00:08:29.540 | all those little sacs
00:08:30.360 | in your lungs.
00:08:30.880 | And then when you breathe out,
00:08:32.660 | you're exhaling
00:08:33.740 | as much of the carbon dioxide
00:08:35.760 | in your system as possible.
00:08:36.980 | when you make exhales longer,
00:08:38.400 | you're slowing your heart rate.
00:08:39.860 | You're calming down.
00:08:40.860 | The opposite is also true.
00:08:43.300 | If you inhale deeply
00:08:45.400 | or vigorously
00:08:46.300 | and then exhale less long
00:08:49.880 | or less vigorously,
00:08:51.100 | you will increase
00:08:52.380 | your level of alertness
00:08:53.360 | through these purely mechanical
00:08:54.940 | aspects of your interoception.
00:08:57.660 | It only takes two or three of those
00:08:59.440 | before you start to feel more alert.
00:09:01.560 | And that's because
00:09:02.360 | your heart rate is increasing.
00:09:03.660 | And actually,
00:09:04.100 | if you keep doing that
00:09:05.020 | for 25 or 30 breaths
00:09:06.400 | of inhale deep,
00:09:07.580 | short exhale,
00:09:08.380 | you will start to secrete
00:09:09.880 | a lot of adrenaline.
00:09:10.980 | You will actually feel
00:09:12.740 | as if you've had
00:09:13.560 | a couple of espresso.
00:09:14.300 | You will immediately wake up
00:09:16.320 | through purely mechanical means.
00:09:18.700 | Changing the way
00:09:20.000 | that you breathe,
00:09:20.800 | emphasizing inhales
00:09:21.960 | or exhales
00:09:22.480 | or keeping them the same
00:09:23.400 | will change the way
00:09:24.080 | that your brain works,
00:09:24.920 | how alert you are
00:09:26.260 | and how well you function
00:09:27.300 | in anything.
00:09:27.820 | And again,
00:09:28.560 | this doesn't mean
00:09:29.800 | that breath work
00:09:30.280 | has no value.
00:09:31.120 | is just simply to say
00:09:32.420 | that long extended protocols
00:09:34.520 | of breath work
00:09:35.060 | are simply,
00:09:35.820 | they are truly simply
00:09:37.680 | just an exploration
00:09:38.680 | of this fundamental relationship
00:09:40.360 | between the mechanics
00:09:41.400 | of your internal organs
00:09:42.960 | and your brain
00:09:44.200 | and how your brain
00:09:45.180 | controls those internal organs.
00:09:46.560 | So now I want to shift
00:09:48.260 | away from breathing
00:09:49.300 | and diaphragm
00:09:50.420 | and lungs
00:09:50.880 | and move toward
00:09:51.720 | another organ
00:09:53.020 | within our viscera,
00:09:54.060 | which is our gut.
00:09:56.120 | So this includes
00:09:56.700 | our stomach
00:09:57.220 | and our intestines,
00:09:58.000 | our esophagus
00:09:58.920 | and so forth.
00:09:59.580 | It's been said before,
00:10:01.340 | both by me
00:10:01.980 | and by others
00:10:02.740 | that we are
00:10:03.580 | but a series of tubes
00:10:04.980 | and indeed that's true.
00:10:06.020 | Believe it or not,
00:10:06.560 | every system in your body
00:10:07.840 | is a tube.
00:10:09.640 | Your brain
00:10:10.380 | is actually a tube
00:10:11.500 | that connects
00:10:12.140 | to your spinal cord,
00:10:12.880 | which is also a tube.
00:10:13.900 | Your digestive system
00:10:15.580 | starts with the tube
00:10:16.660 | at your mouth
00:10:17.500 | and of course
00:10:19.740 | goes down
00:10:20.160 | through your throat
00:10:20.860 | and then you've got
00:10:22.120 | all the elements
00:10:22.660 | of the stomach
00:10:23.180 | and the intestines
00:10:23.880 | and then it comes out
00:10:24.980 | the other end.
00:10:25.820 | So you are
00:10:26.320 | but a series
00:10:26.860 | of different tubes,
00:10:27.680 | your vascular system,
00:10:28.700 | a series of other tubes.
00:10:29.680 | The way your digestive system
00:10:31.760 | works
00:10:32.580 | is to communicate
00:10:33.680 | to your brain
00:10:34.520 | about the status
00:10:35.820 | of the mechanical pressures
00:10:37.660 | along this tube.
00:10:38.900 | So within your stomach
00:10:40.080 | and your intestines,
00:10:40.760 | et cetera,
00:10:41.240 | and the chemical status
00:10:43.040 | of that tube
00:10:44.460 | at various portions
00:10:45.780 | within that tube
00:10:46.520 | to inform your brain
00:10:49.120 | about how your brain
00:10:50.700 | should control that tube.
00:10:52.240 | So let's start
00:10:54.200 | with the mechanical
00:10:55.060 | mechanical sensing
00:10:56.000 | of your gut.
00:10:57.040 | If you drink
00:10:58.780 | a lot of fluid
00:10:59.440 | or if you eat
00:11:01.280 | a lot of food,
00:11:01.940 | your gut will fill up.
00:11:03.560 | If there's a lot
00:11:04.240 | of that food,
00:11:04.840 | pressure receptors
00:11:06.120 | communicate to the areas
00:11:07.460 | of your brain
00:11:07.940 | that are involved
00:11:08.480 | in feeding
00:11:09.080 | and will say,
00:11:10.120 | don't eat anymore.
00:11:11.200 | You don't need
00:11:12.040 | to consume anymore.
00:11:12.860 | The converse
00:11:13.640 | is also true
00:11:14.520 | when these receptors
00:11:15.720 | signal to the brain
00:11:16.560 | that the gut
00:11:17.000 | is empty.
00:11:18.160 | So when you find
00:11:19.200 | yourself at the refrigerator
00:11:20.300 | or you find yourself
00:11:21.800 | almost manically
00:11:23.560 | trying to get food
00:11:24.540 | of different kinds,
00:11:25.120 | you're not even thinking
00:11:25.900 | about what you're eating
00:11:26.620 | because you're so hungry.
00:11:27.620 | In part,
00:11:28.620 | that's because
00:11:29.220 | the lack of food
00:11:30.160 | in your gut
00:11:30.640 | has sent
00:11:31.720 | that information
00:11:32.840 | to your brain
00:11:33.780 | and is driving
00:11:34.740 | particular fixed action
00:11:36.560 | patterns
00:11:37.020 | that are associated
00:11:37.660 | with eating.
00:11:38.220 | So if you've eaten
00:11:38.980 | anything,
00:11:39.660 | even if it's
00:11:40.280 | a small volume
00:11:40.900 | of food
00:11:41.260 | in the last
00:11:41.900 | hour to three hours,
00:11:43.300 | it's actually
00:11:44.760 | a worthwhile practice
00:11:45.800 | to take a few moments,
00:11:46.880 | maybe 10,
00:11:47.500 | 20 seconds
00:11:48.280 | and actually
00:11:49.240 | just try and concentrate
00:11:50.420 | on sensing
00:11:51.500 | the neurons
00:11:52.600 | in your gut
00:11:53.240 | and how full you are.
00:11:54.120 | The consequence of that
00:11:55.100 | is actually
00:11:55.480 | rather interesting.
00:11:56.160 | It's been shown
00:11:56.720 | that the consequence
00:11:57.400 | of that is actually
00:11:58.140 | that you can better
00:11:59.000 | override the signals
00:12:00.780 | of gut fullness
00:12:01.480 | or emptiness.
00:12:02.260 | So there are other ways
00:12:03.860 | that our guts
00:12:04.540 | communicate with our brain.
00:12:05.700 | It's not just our stomach
00:12:06.800 | talking to our brain.
00:12:07.900 | it's also our intestines
00:12:09.440 | talk to our brain.
00:12:10.620 | The Lieberle's lab,
00:12:13.480 | the guy's name
00:12:14.300 | is Stephen Lieberle's.
00:12:15.280 | He runs a lab
00:12:15.860 | at Harvard Medical School.
00:12:16.780 | They discovered
00:12:17.340 | a category of neurons
00:12:18.740 | called the GLP1R neurons
00:12:21.340 | and those neurons
00:12:22.060 | send little wires
00:12:23.160 | down into the intestines
00:12:26.340 | and deep into the stomach
00:12:28.860 | but mostly into the intestines
00:12:30.980 | and they sense stretch
00:12:33.020 | of your intestines
00:12:33.940 | and then those neurons
00:12:35.580 | send another branch.
00:12:36.760 | So they have a branch
00:12:37.260 | in one direction
00:12:37.920 | senses what's going
00:12:39.180 | on in your intestines
00:12:39.820 | and they have another branch
00:12:41.040 | that goes up from your neck
00:12:42.480 | into your brain
00:12:43.320 | to either trigger
00:12:44.060 | the desire to eat more
00:12:45.640 | or to stop eating.
00:12:46.740 | So these are really,
00:12:47.840 | really cool neurons
00:12:48.620 | and they're basically
00:12:49.160 | stretch receptors.
00:12:49.920 | and in addition to that,
00:12:51.440 | the Lieberle's lab discovered neurons
00:12:54.300 | that detect nutrients themselves.
00:12:56.420 | These neurons are activated
00:12:57.920 | by the presence
00:12:58.680 | of fatty acids,
00:13:00.380 | amino acids
00:13:01.640 | and as a third food item,
00:13:03.640 | sugars are coming
00:13:05.180 | from the foods
00:13:06.400 | that we eat.
00:13:06.940 | These neurons
00:13:07.740 | will fire a lot
00:13:09.040 | to the brain
00:13:09.540 | that says,
00:13:10.340 | whatever you're doing up there,
00:13:11.680 | do more of it.
00:13:12.820 | Now the sugars
00:13:14.100 | are a little bit cryptic
00:13:15.300 | because when I say sugars
00:13:16.780 | or I say amino acids
00:13:18.200 | or I say fatty acids,
00:13:20.480 | this has nothing
00:13:21.820 | to do with taste.
00:13:22.840 | In fact,
00:13:23.720 | beautiful experiments
00:13:24.580 | have been done
00:13:25.140 | by the Borges lab
00:13:26.440 | and by other labs
00:13:27.240 | showing that even
00:13:28.380 | if you numb the mouth,
00:13:29.800 | even if you gavage,
00:13:31.960 | which is a really just,
00:13:32.900 | it's a fancy word
00:13:34.000 | for basically tube feeding.
00:13:35.600 | You put a tube
00:13:36.460 | down in the gut,
00:13:36.980 | you just deliver
00:13:37.540 | the food to the gut
00:13:38.180 | so you get no opportunity
00:13:39.200 | to taste it.
00:13:39.980 | Sounds pretty awful.
00:13:41.000 | If you force feed
00:13:42.200 | by gavage
00:13:43.080 | or you numb the mouth,
00:13:44.600 | these neurons
00:13:45.460 | don't care about the mouth.
00:13:47.180 | They only care about
00:13:48.320 | the nutrients
00:13:48.860 | coming from these foods
00:13:49.820 | and then they signal
00:13:50.660 | to the brain,
00:13:51.580 | do that thing.
00:13:52.620 | Do that thing
00:13:53.200 | where you lift that object
00:13:55.000 | we call a fork
00:13:55.720 | or a spoon.
00:13:56.200 | Do that thing
00:13:56.780 | where you drink
00:13:57.680 | the milkshake.
00:13:58.260 | Do that thing
00:13:58.800 | where you move
00:13:59.440 | your mouth like this,
00:14:00.340 | not talking,
00:14:01.020 | but do that thing
00:14:01.720 | where you swallow.
00:14:02.380 | So that's how
00:14:03.740 | the nutrients
00:14:04.720 | in our gut control us
00:14:05.880 | and this is why
00:14:06.540 | for people that
00:14:07.320 | experience
00:14:08.340 | extreme sugar cravings
00:14:09.680 | or even mild sugar cravings,
00:14:11.360 | replacing those foods
00:14:12.780 | with foods
00:14:13.240 | that have high levels
00:14:14.220 | of omega-3
00:14:15.100 | or amino acids
00:14:16.640 | can reduce sugar cravings
00:14:18.080 | and I've talked about this
00:14:18.900 | on a previous episode
00:14:20.080 | but the point is
00:14:22.280 | these neurons
00:14:24.000 | don't really know taste.
00:14:25.360 | They only know nutrients
00:14:26.660 | and so you can work
00:14:27.680 | with that system
00:14:28.320 | if you crave sugar
00:14:29.680 | and I do believe
00:14:30.460 | that most
00:14:31.420 | if not all of us
00:14:32.120 | should be trying to limit
00:14:33.220 | if not eliminate
00:14:34.160 | simple sugars
00:14:35.120 | as much as possible
00:14:36.460 | most of the time
00:14:37.440 | then things like
00:14:39.460 | high omega-3 foods
00:14:41.660 | Maybe you even want
00:14:42.500 | to supplement
00:14:42.900 | with fish oil
00:14:43.620 | or something similar
00:14:44.780 | to get omega-3s
00:14:45.620 | there are other reasons
00:14:46.260 | for wanting to do that too
00:14:47.200 | can be very beneficial
00:14:48.420 | and here's what
00:14:49.440 | we're talking about
00:14:50.360 | is interoception.
00:14:51.840 | It's your ability
00:14:53.340 | to sense your inner
00:14:54.520 | real estate
00:14:55.180 | but in this case
00:14:56.300 | by way of chemical signaling
00:14:57.840 | not by way of
00:14:58.700 | mechanical signaling.
00:15:00.440 | so now I'd like
00:15:01.120 | to talk about
00:15:01.600 | another aspect
00:15:02.520 | of gut chemistry
00:15:03.900 | that has
00:15:05.200 | profound effects
00:15:06.260 | on the brain
00:15:07.060 | as well as
00:15:07.720 | on the immune system.
00:15:08.720 | Your gut needs
00:15:09.960 | to maintain
00:15:10.600 | a certain level
00:15:11.480 | of acidity
00:15:12.440 | or alkalinity.
00:15:13.580 | For those of you
00:15:14.540 | without any chemistry
00:15:15.360 | background
00:15:15.940 | basically the low numbers
00:15:18.480 | on the pH scale
00:15:19.880 | that means more acidic.
00:15:20.880 | The higher the numbers
00:15:22.300 | more alkaline.
00:15:23.940 | So more alkaline
00:15:24.980 | means more basic
00:15:25.900 | and acidic
00:15:27.060 | means acidic.
00:15:27.840 | Your gut needs
00:15:28.880 | to be more acidic
00:15:29.840 | than essentially
00:15:30.880 | all other tissues
00:15:31.780 | of your body
00:15:32.340 | in order to function
00:15:33.200 | properly.
00:15:33.740 | Gastric juices
00:15:35.320 | are actually
00:15:36.400 | powerful modulators
00:15:37.880 | of brain state.
00:15:39.020 | Put differently
00:15:40.120 | one of the best
00:15:41.020 | things that you can do
00:15:41.920 | to have a healthy brain
00:15:43.020 | a well-functioning brain
00:15:44.080 | and a healthy
00:15:44.620 | and well-functioning body
00:15:45.620 | is to maintain
00:15:46.560 | proper gut chemistry
00:15:48.360 | and that's
00:15:49.280 | basically accomplished
00:15:50.320 | by getting
00:15:51.280 | the right level
00:15:52.220 | of acidity
00:15:53.020 | and alkalinity
00:15:53.760 | in your gut.
00:15:55.160 | Now this is not
00:15:56.020 | quack pseudoscience
00:15:57.140 | but we're going
00:15:57.500 | to talk about now
00:15:58.340 | our peer-reviewed data
00:15:59.760 | that point to
00:16:00.700 | the gut microbiome
00:16:01.960 | and its relationship
00:16:02.820 | to acidity of the gut
00:16:04.120 | and how the gut microbiome
00:16:05.780 | can help enhance
00:16:07.200 | autoimmune function
00:16:10.000 | and various other aspects
00:16:11.720 | of brain and body health.
00:16:12.780 | So within all
00:16:13.900 | the mucosal line
00:16:15.200 | tissues of our body
00:16:16.260 | we have what are called
00:16:18.120 | microbiota
00:16:19.280 | little microorganisms
00:16:20.860 | that we didn't make
00:16:21.760 | that actually come
00:16:22.360 | from our environment
00:16:23.260 | or our food
00:16:24.660 | and live inside us
00:16:27.220 | and there are good
00:16:28.700 | microbiota
00:16:29.500 | and there are bad
00:16:30.340 | microbiota
00:16:31.140 | whether or not
00:16:33.140 | we have
00:16:33.720 | good microbiota
00:16:35.540 | or bad microbiota
00:16:36.880 | depends on
00:16:37.580 | one thing
00:16:38.360 | and that one thing
00:16:39.700 | is how acid
00:16:40.880 | or alkaline
00:16:42.040 | the given
00:16:43.080 | mucosal tissue
00:16:44.360 | What you essentially
00:16:45.560 | want to do
00:16:46.280 | is create
00:16:47.240 | an environment
00:16:47.940 | where the proper
00:16:49.520 | microbiota
00:16:50.200 | can thrive
00:16:50.880 | because when
00:16:51.600 | you do that
00:16:52.360 | you greatly
00:16:53.620 | decrease
00:16:54.260 | what are called
00:16:55.240 | inflammatory cytokines
00:16:56.900 | so these are things
00:16:57.540 | that are secreted
00:16:58.300 | both by cells
00:16:59.360 | within the body
00:17:00.000 | and cells
00:17:00.780 | within the brain
00:17:01.540 | to impact
00:17:02.520 | brain health
00:17:03.320 | and brain function
00:17:04.140 | and bodily health.
00:17:05.000 | the simple way
00:17:06.220 | to adjust
00:17:07.020 | these things
00:17:07.560 | in the proper
00:17:08.420 | ratios
00:17:09.520 | is to adjust
00:17:11.280 | your gut microbiome
00:17:12.280 | the best way
00:17:12.760 | to adjust
00:17:13.080 | your microbiome
00:17:13.840 | is to ingest
00:17:15.020 | certain types
00:17:15.880 | of foods.
00:17:16.300 | There was a study
00:17:17.520 | done by my colleague
00:17:18.880 | Justin Sonnenberg
00:17:19.820 | at Stanford School
00:17:21.020 | of Medicine
00:17:21.460 | they explored
00:17:22.360 | how different foods
00:17:23.660 | or different diets
00:17:25.160 | I should say
00:17:25.840 | impact the gut microbiome
00:17:27.780 | and inflammatory markers
00:17:29.080 | and what they did
00:17:30.060 | is they explored
00:17:30.840 | two types of diets
00:17:32.040 | one is a high fiber diet
00:17:33.720 | and they compared
00:17:34.720 | that to diets
00:17:35.760 | that were unchanged
00:17:36.780 | except for the inclusion
00:17:37.760 | of a few
00:17:39.140 | to a few more
00:17:40.720 | servings of fermented
00:17:41.960 | foods each day
00:17:42.840 | and the takeaway
00:17:44.000 | message from this study
00:17:45.020 | is that the fermented
00:17:46.100 | foods far outperformed
00:17:48.080 | the high fiber diet
00:17:50.240 | the bigger message
00:17:51.000 | is that all of us
00:17:52.440 | should be ingesting
00:17:54.240 | on a regular basis
00:17:55.780 | daily basis
00:17:56.500 | fermented foods
00:17:57.420 | of different kinds
00:17:58.140 | and why
00:17:58.520 | I say that
00:18:00.140 | is because
00:18:00.620 | the inflammatory markers
00:18:01.800 | went down
00:18:02.360 | the markers
00:18:03.900 | of autoimmune
00:18:04.840 | disruption
00:18:05.700 | went down
00:18:07.520 | and the chemistry
00:18:09.520 | of the gut
00:18:10.140 | therefore
00:18:10.540 | was adjusted
00:18:11.780 | in the appropriate ways
00:18:13.040 | and it's been shown
00:18:14.080 | in other studies
00:18:15.120 | that when
00:18:16.040 | the correct gut
00:18:17.700 | microbiota
00:18:18.560 | are present
00:18:19.380 | and these inflammatory
00:18:20.700 | markers are reduced
00:18:22.080 | cognition improves
00:18:23.880 | so ability to focus
00:18:25.140 | ability to sleep
00:18:26.460 | ability to ward off
00:18:27.520 | infection
00:18:27.980 | and wound healing
00:18:28.860 | all enhanced
00:18:29.920 | so while today
00:18:30.920 | is about interoception
00:18:32.140 | we're talking
00:18:32.600 | about sensing
00:18:33.380 | we're also talking
00:18:34.160 | about subconscious
00:18:34.840 | sensing
00:18:35.340 | we're talking
00:18:36.120 | about subconscious
00:18:36.820 | sensing
00:18:37.280 | of the milieu
00:18:38.300 | of the body
00:18:39.180 | when the milieu
00:18:39.780 | of the gut
00:18:40.440 | in the body
00:18:41.040 | is right
00:18:42.100 | then the brain
00:18:43.280 | and the immune
00:18:44.120 | system function
00:18:45.040 | very well
00:18:45.800 | it's very clear
00:18:46.700 | that's fermented foods
00:18:47.760 | and that's keeping
00:18:48.400 | the stomach
00:18:49.340 | slightly more acid
00:18:50.920 | than one might think
00:18:51.760 | you would want to
00:18:52.640 | so now I want
00:18:53.720 | to talk about
00:18:54.300 | two other forms
00:18:55.620 | of mechanical
00:18:56.820 | and chemical
00:18:57.540 | sensing
00:18:58.000 | that we
00:18:59.320 | very much
00:19:00.440 | can detect
00:19:01.200 | at a conscious
00:19:01.760 | level
00:19:02.100 | and those are
00:19:03.340 | fever
00:19:03.920 | and barfing
00:19:05.160 | so let's talk
00:19:06.200 | about barfing
00:19:06.820 | first
00:19:07.260 | barfing
00:19:08.620 | aka vomiting
00:19:09.820 | is when
00:19:10.960 | the contents
00:19:12.680 | of your guts
00:19:13.380 | run in reverse
00:19:14.440 | meaning when they
00:19:15.440 | go up from
00:19:16.260 | your stomach
00:19:16.840 | out the esophagus
00:19:17.980 | and mouth
00:19:18.460 | and onto
00:19:20.320 | whatever surface
00:19:21.020 | happens to be
00:19:21.780 | in front of you
00:19:22.440 | it's a terrible
00:19:23.400 | thing nobody
00:19:23.920 | likes to do it
00:19:24.660 | but it's a very
00:19:26.300 | interesting aspect
00:19:27.340 | to our biology
00:19:28.060 | because it reveals
00:19:29.200 | a beautiful
00:19:30.760 | and absolutely
00:19:31.940 | fundamental
00:19:32.560 | relationship
00:19:33.180 | between our
00:19:34.180 | chemistry
00:19:34.740 | and our brain
00:19:36.820 | so your brain
00:19:39.080 | is actually
00:19:40.320 | locked behind
00:19:41.260 | a gate
00:19:41.780 | and that gate
00:19:42.820 | is not your skull
00:19:43.880 | that gate
00:19:45.440 | is the so-called
00:19:46.260 | blood-brain barrier
00:19:47.440 | it's absolutely
00:19:48.700 | fundamental
00:19:49.380 | that only
00:19:50.800 | certain molecules
00:19:51.680 | get across
00:19:52.420 | the blood-brain barrier
00:19:53.280 | and that others
00:19:53.980 | don't
00:19:54.440 | and the reason
00:19:55.040 | for that
00:19:55.520 | is that
00:19:56.400 | most all
00:19:57.500 | 99.9999%
00:19:59.900 | of your neurons
00:20:00.980 | do not regenerate
00:20:02.400 | I don't care
00:20:03.140 | what you've read
00:20:03.960 | especially in the news
00:20:04.780 | recently about how
00:20:05.680 | psychedelics cause
00:20:06.400 | neurogenesis
00:20:06.980 | because they don't
00:20:08.260 | it's absolutely
00:20:09.040 | wrong
00:20:09.620 | psychedelics have
00:20:10.640 | effects on brain
00:20:11.320 | plasticity
00:20:11.760 | but they have
00:20:12.160 | nothing to do
00:20:12.820 | with neurogenesis
00:20:13.460 | at least no data
00:20:14.160 | support it
00:20:14.640 | but because
00:20:16.100 | you can't make
00:20:17.040 | new neurons
00:20:17.840 | you also
00:20:19.380 | can't damage
00:20:20.300 | the ones
00:20:20.700 | you've got
00:20:21.240 | or you shouldn't
00:20:22.100 | as much as possible
00:20:22.960 | and that's why
00:20:23.460 | you have a
00:20:24.080 | blood-brain barrier
00:20:25.340 | or a BBB
00:20:26.560 | so the BBB
00:20:28.720 | as it's called
00:20:30.600 | prevents substances
00:20:32.420 | from getting
00:20:33.200 | to the brain
00:20:34.180 | however
00:20:35.700 | like any fence
00:20:37.900 | it is not
00:20:39.140 | always uniform
00:20:40.200 | along its length
00:20:41.440 | and there are
00:20:42.100 | little spots
00:20:43.020 | within that fence
00:20:43.980 | where chemicals
00:20:45.600 | can sneak
00:20:46.680 | across to the
00:20:47.440 | brain
00:20:47.740 | but through a
00:20:49.560 | beautiful design
00:20:50.360 | of some sort
00:20:51.320 | there are little
00:20:53.720 | holes in that
00:20:54.520 | fence
00:20:54.900 | and there are
00:20:55.940 | little neurons
00:20:56.640 | that sit right
00:20:57.920 | behind those holes
00:20:58.860 | and those neurons
00:21:00.280 | sense what the
00:21:02.140 | chemistry of the
00:21:02.920 | blood is
00:21:03.700 | so I'm guessing
00:21:05.040 | you probably didn't
00:21:05.640 | imagine that today's
00:21:06.420 | discussion about
00:21:07.040 | sensing the self
00:21:07.740 | would be sensing
00:21:08.360 | your own blood
00:21:09.320 | but you do
00:21:10.260 | there is a
00:21:11.020 | little area
00:21:11.720 | of your brain
00:21:12.300 | that's little
00:21:12.980 | indeed but is
00:21:13.920 | very very important
00:21:14.780 | called area
00:21:15.500 | postrema
00:21:16.320 | p-o-s-t-r-e-m-a
00:21:19.420 | an area postrema
00:21:21.160 | is an area
00:21:21.860 | of the brainstem
00:21:22.540 | that sits right
00:21:24.440 | next to another
00:21:24.940 | brain area
00:21:25.500 | called the
00:21:26.340 | chemoreceptor
00:21:27.080 | trigger zone
00:21:27.960 | and when
00:21:29.460 | the contents
00:21:30.840 | in your bloodstream
00:21:31.980 | are of a
00:21:33.700 | particular kind
00:21:34.540 | meaning when
00:21:35.260 | there are
00:21:35.860 | pathogens
00:21:36.480 | or it's
00:21:37.880 | too acidic
00:21:38.580 | the neurons
00:21:40.640 | in area
00:21:41.080 | postrema
00:21:41.700 | and the neurons
00:21:43.180 | in the chemoreceptor
00:21:44.440 | trigger zone
00:21:45.480 | trigger a bunch
00:21:46.340 | of motor
00:21:46.980 | reflexes
00:21:47.780 | in the abdominal
00:21:49.900 | that make you
00:21:54.060 | the feeling
00:21:55.500 | that you need
00:21:56.080 | to throw up
00:21:56.860 | is triggered
00:21:57.700 | by these neurons
00:21:58.320 | in the brainstem
00:21:59.000 | and those neurons
00:21:59.580 | in the brainstem
00:22:00.120 | are triggered
00:22:00.720 | by the presence
00:22:01.620 | of certain chemicals
00:22:02.700 | and the reason
00:22:03.840 | why you don't
00:22:04.400 | have any blood
00:22:04.900 | brain barrier
00:22:05.520 | at that location
00:22:06.480 | is because postrema
00:22:07.520 | has to be there
00:22:08.360 | like a crossing
00:22:09.500 | guard
00:22:09.880 | making sure
00:22:10.660 | that everything
00:22:11.340 | that's coming
00:22:11.880 | through the blood
00:22:12.580 | is okay
00:22:13.500 | and if it even
00:22:14.520 | senses just the
00:22:15.300 | tiniest bit
00:22:16.100 | that things are
00:22:17.300 | it's going to
00:22:17.900 | trigger that
00:22:18.440 | reflex
00:22:19.140 | some people
00:22:21.220 | the memory
00:22:21.860 | of or the
00:22:23.580 | thought of
00:22:24.140 | something like
00:22:24.740 | blood or
00:22:25.520 | vomit or
00:22:26.260 | use your
00:22:26.780 | imagination
00:22:27.320 | can actually
00:22:28.100 | trigger the
00:22:28.840 | vomit reflex
00:22:29.820 | and that's
00:22:30.880 | because these
00:22:31.440 | neurons in
00:22:31.940 | area postrema
00:22:32.640 | are very
00:22:34.240 | sensitive to
00:22:34.960 | prior experience
00:22:36.040 | of interactions
00:22:37.220 | with negative
00:22:38.380 | things
00:22:38.880 | the neurons
00:22:39.880 | of area
00:22:40.340 | postrema
00:22:41.000 | are there
00:22:42.460 | basically to
00:22:43.360 | keep your
00:22:43.880 | whole system
00:22:45.060 | so let's
00:22:45.720 | talk for a
00:22:46.160 | second about
00:22:46.660 | how to
00:22:47.280 | reduce nausea
00:22:48.640 | because nausea
00:22:49.720 | that salivation
00:22:50.800 | that feeling
00:22:51.220 | that you're
00:22:51.480 | going to
00:22:51.640 | vomit
00:22:51.880 | can be very
00:22:53.320 | beneficial
00:22:53.760 | and in an
00:22:54.320 | adaptive
00:22:55.300 | circumstance
00:22:55.920 | like you've
00:22:56.820 | ingested
00:22:57.120 | something bad
00:22:57.700 | but some
00:22:58.040 | people experience
00:22:58.660 | nausea
00:22:59.200 | for other
00:23:00.020 | reasons
00:23:00.400 | there are
00:23:01.660 | good ways
00:23:02.700 | to regulate
00:23:03.340 | nausea
00:23:03.880 | and the
00:23:04.580 | ways they
00:23:05.040 | regulate
00:23:05.760 | nausea
00:23:06.080 | are very
00:23:06.340 | interesting
00:23:06.660 | they actually
00:23:07.180 | adjust the
00:23:07.760 | activity
00:23:08.240 | of these
00:23:09.720 | neurons in
00:23:10.200 | area postrema
00:23:10.960 | or they
00:23:11.840 | change the
00:23:12.420 | chemistry of
00:23:12.940 | the blood
00:23:13.300 | directly
00:23:13.920 | and many
00:23:15.540 | of you have
00:23:15.940 | heard this
00:23:16.260 | before perhaps
00:23:17.120 | but it
00:23:17.560 | turns out
00:23:18.020 | that there
00:23:18.400 | are good
00:23:19.380 | 11 research
00:23:20.480 | studies were
00:23:21.000 | the ones
00:23:21.280 | that I
00:23:21.540 | could find
00:23:21.920 | peer-reviewed
00:23:22.480 | research studies
00:23:23.100 | with no
00:23:24.180 | so independent
00:23:24.660 | studies
00:23:25.020 | showing that
00:23:25.760 | ginger
00:23:26.160 | can cause
00:23:28.260 | a notable
00:23:28.940 | reduction
00:23:29.940 | in nausea
00:23:30.900 | how much
00:23:31.520 | ginger
00:23:31.860 | one to
00:23:32.420 | three grams
00:23:33.040 | and some
00:23:33.980 | of you
00:23:34.340 | will not
00:23:34.940 | be surprised
00:23:35.500 | to learn
00:23:35.900 | that cannabis
00:23:36.700 | can reduce
00:23:37.900 | nausea
00:23:38.440 | but cannabis
00:23:39.980 | and or
00:23:41.560 | it turns
00:23:41.960 | out CBD
00:23:42.680 | can reduce
00:23:44.280 | nausea
00:23:44.860 | and it
00:23:45.280 | probably
00:23:45.940 | does that
00:23:46.660 | by changing
00:23:47.660 | the threshold
00:23:49.320 | for firing
00:23:50.060 | of these
00:23:50.520 | neurons
00:23:50.860 | in area
00:23:51.280 | postrema
00:23:51.800 | now let's
00:23:52.600 | talk about
00:23:53.060 | fever
00:23:53.480 | a fever
00:23:55.000 | is simply
00:23:55.640 | an increase
00:23:56.120 | in body
00:23:56.500 | temperature
00:23:56.960 | that increase
00:23:58.440 | in body
00:23:58.800 | temperature
00:23:59.080 | is triggered
00:23:59.640 | by neurons
00:24:00.240 | in the
00:24:00.680 | brain
00:24:01.080 | and those
00:24:02.340 | neurons
00:24:02.660 | in the
00:24:02.920 | brain
00:24:03.160 | are triggered
00:24:03.820 | by the
00:24:04.220 | presence
00:24:04.680 | of particular
00:24:05.420 | things
00:24:05.840 | in the
00:24:06.140 | bloodstream
00:24:06.600 | what sorts
00:24:08.860 | of things
00:24:10.000 | toxins
00:24:11.060 | bacteria
00:24:12.360 | viruses
00:24:13.460 | when something
00:24:14.380 | bad gets
00:24:15.120 | in our
00:24:15.400 | system
00:24:15.780 | the body
00:24:16.760 | doesn't know
00:24:17.480 | it's bad
00:24:18.420 | it just
00:24:19.280 | knows it's
00:24:19.820 | foreign
00:24:20.220 | your body
00:24:21.020 | has this
00:24:21.480 | intelligence
00:24:22.100 | and that
00:24:22.520 | intelligence
00:24:22.920 | is to
00:24:24.180 | these proteins
00:24:25.020 | are normally
00:24:25.480 | not seen
00:24:26.000 | in this
00:24:26.300 | region
00:24:26.640 | and then
00:24:27.580 | your body
00:24:28.440 | or the
00:24:28.740 | cells
00:24:29.000 | there
00:24:29.180 | i should
00:24:29.840 | release
00:24:30.300 | something
00:24:31.880 | travel
00:24:32.260 | to the
00:24:32.580 | brain
00:24:32.900 | and will
00:24:33.800 | trigger
00:24:34.240 | an increase
00:24:35.020 | in body
00:24:35.440 | temperature
00:24:35.880 | so that
00:24:36.340 | your body
00:24:36.720 | cooks
00:24:37.180 | the bad
00:24:37.800 | thing
00:24:38.120 | or the
00:24:38.740 | cause
00:24:39.060 | of the
00:24:39.500 | thing
00:24:39.880 | really
00:24:40.400 | beautiful
00:24:40.720 | adaptive
00:24:41.160 | mechanism
00:24:42.000 | what's
00:24:43.360 | beautiful
00:24:43.760 | about
00:24:44.340 | fever
00:24:44.580 | mechanism
00:24:45.820 | looks
00:24:46.000 | a lot
00:24:46.580 | barfing
00:24:46.920 | mechanism
00:24:47.400 | basically
00:24:48.920 | a set
00:24:49.440 | neurons
00:24:51.060 | ventricles
00:24:53.040 | series
00:24:53.440 | tubes
00:24:54.360 | brain
00:24:55.820 | middle
00:24:56.420 | extends
00:24:57.200 | bottom
00:24:57.640 | spinal
00:24:58.820 | front
00:24:59.880 | called
00:25:00.160 | ventricles
00:25:00.680 | and you
00:25:01.380 | ventricle
00:25:02.060 | third
00:25:02.340 | ventricle
00:25:02.960 | along
00:25:04.440 | third
00:25:04.680 | ventricle
00:25:05.080 | there's
00:25:05.400 | there are
00:25:05.760 | little
00:25:05.980 | neurons
00:25:07.040 | sense
00:25:07.500 | what's
00:25:08.500 | cerebral
00:25:08.860 | spinal
00:25:09.280 | fluid
00:25:09.780 | fills
00:25:10.160 | ventricle
00:25:10.900 | other
00:25:11.060 | words
00:25:11.860 | neurons
00:25:12.520 | sensing
00:25:13.320 | chemistry
00:25:14.180 | cerebral
00:25:14.520 | spinal
00:25:14.900 | fluid
00:25:17.500 | access
00:25:18.120 | therefore
00:25:20.100 | chemistry
00:25:21.420 | because
00:25:22.240 | cerebral
00:25:22.500 | spinal
00:25:22.900 | fluid
00:25:23.860 | going
00:25:24.980 | brain
00:25:25.320 | spinal
00:25:27.100 | cerebral
00:25:27.360 | spinal
00:25:27.720 | fluid
00:25:28.580 | signals
00:25:29.040 | about
00:25:29.420 | various
00:25:29.660 | chemicals
00:25:30.040 | within
00:25:31.500 | mechanical
00:25:32.160 | system
00:25:33.200 | chemical
00:25:33.600 | system
00:25:34.440 | remember
00:25:34.780 | we're
00:25:34.960 | talking
00:25:35.060 | about
00:25:35.200 | mechanical
00:25:35.700 | information
00:25:36.820 | chemical
00:25:37.260 | information
00:25:37.860 | accessing
00:25:38.820 | brain
00:25:39.480 | neurons
00:25:40.540 | these
00:25:40.780 | ventricles
00:25:41.500 | cerebral
00:25:41.800 | spinal
00:25:42.100 | fluid
00:25:42.420 | go by
00:25:43.120 | particular
00:25:43.880 | they're
00:25:44.620 | called
00:25:44.800 | circumventricular
00:25:46.180 | organs
00:25:46.740 | meaning
00:25:47.880 | circumventricular
00:25:49.360 | near the
00:25:49.820 | ventricles
00:25:50.420 | and you
00:25:50.880 | have these
00:25:51.160 | organs
00:25:52.000 | there's
00:25:52.520 | a set
00:25:52.940 | neurons
00:25:53.220 | has a
00:25:53.560 | really
00:25:54.240 | called
00:25:55.320 | I don't
00:25:55.840 | know why
00:25:56.060 | I like
00:25:56.400 | but I
00:25:57.200 | organum
00:25:57.860 | vasculosum
00:25:59.020 | of the
00:25:59.420 | lateral
00:25:59.800 | terminalis
00:26:00.780 | organum
00:26:01.480 | vasculosum
00:26:02.040 | lateral
00:26:02.320 | terminalis
00:26:04.080 | are the
00:26:05.300 | neurons
00:26:06.240 | respond
00:26:07.200 | toxins
00:26:09.200 | stuff
00:26:09.500 | in your
00:26:09.720 | bloodstream
00:26:10.320 | however
00:26:10.640 | minor
00:26:11.160 | major
00:26:11.440 | what's
00:26:12.080 | going
00:26:12.280 | happen
00:26:13.440 | those
00:26:14.320 | neurons
00:26:14.820 | activated
00:26:15.360 | because
00:26:15.880 | something
00:26:17.180 | something
00:26:18.340 | happening
00:26:20.480 | communicate
00:26:21.460 | of the
00:26:21.640 | brain
00:26:21.800 | called
00:26:22.180 | preoptic
00:26:23.640 | hypothalamus
00:26:24.640 | preoptic
00:26:25.480 | cranks
00:26:26.580 | temperature
00:26:27.120 | tries
00:26:28.280 | thing
00:26:31.040 | worth
00:26:31.300 | talking
00:26:31.700 | about
00:26:31.940 | fever
00:26:32.200 | for a
00:26:32.600 | moment
00:26:33.200 | talking
00:26:33.440 | about
00:26:33.600 | thermal
00:26:33.880 | regulation
00:26:34.380 | because
00:26:34.880 | think
00:26:35.480 | actually
00:26:35.700 | could
00:26:36.360 | lives
00:26:39.260 | overheated
00:26:41.760 | point
00:26:42.480 | where
00:26:42.920 | you know
00:26:43.180 | you're
00:26:43.300 | getting
00:26:44.220 | or 103
00:26:45.280 | going
00:26:45.900 | depending
00:26:46.520 | person
00:26:46.880 | person
00:26:47.240 | certainly
00:26:48.000 | you know
00:26:49.980 | people
00:26:50.180 | think
00:26:50.700 | tolerate
00:26:50.980 | higher
00:26:51.260 | levels
00:26:51.660 | fever
00:26:52.080 | adults
00:26:53.240 | always
00:26:53.920 | cautious
00:26:54.180 | about
00:26:54.420 | heating
00:26:55.020 | brain
00:26:55.640 | because
00:26:56.100 | those
00:26:56.280 | neurons
00:26:58.080 | neurons
00:26:59.840 | temperatures
00:27:01.860 | temperature
00:27:02.180 | starts
00:27:02.540 | getting
00:27:04.900 | certainly
00:27:06.500 | you are
00:27:06.980 | starting
00:27:07.200 | to enter
00:27:07.500 | serious
00:27:07.960 | danger
00:27:09.400 | happen
00:27:09.700 | through
00:27:09.960 | exercise
00:27:10.880 | environments
00:27:12.440 | inability
00:27:13.100 | escape
00:27:13.900 | because
00:27:15.260 | don't
00:27:15.560 | covering
00:27:16.220 | adequate
00:27:16.780 | ventilation
00:27:18.260 | cooling
00:27:19.780 | because
00:27:20.340 | excessive
00:27:20.760 | fever
00:27:21.380 | whatever
00:27:21.640 | reason
00:27:23.040 | people
00:27:23.260 | think
00:27:25.640 | compress
00:27:29.200 | torso
00:27:30.920 | clear
00:27:31.320 | that's
00:27:31.720 | wrong
00:27:32.060 | response
00:27:37.420 | towel
00:27:41.020 | effectively
00:27:42.680 | blood
00:27:42.880 | that's
00:27:43.100 | going
00:27:43.560 | brain
00:27:46.840 | brain
00:27:47.320 | react
00:27:48.240 | turning
00:27:49.160 | crank
00:27:50.940 | speak
00:27:52.040 | neurons
00:27:52.920 | pre-optic
00:27:54.600 | further
00:27:55.820 | brain
00:27:56.400 | organs
00:27:56.740 | further
00:27:59.760 | talked
00:27:59.920 | about
00:28:00.080 | before
00:28:02.300 | bottoms
00:28:03.920 | palms
00:28:04.720 | hands
00:28:05.380 | upper
00:28:10.480 | under
00:28:10.800 | covers
00:28:13.700 | something
00:28:14.460 | really
00:28:16.080 | create
00:28:16.660 | systemic
00:28:17.320 | whole
00:28:17.740 | cooling
00:28:19.080 | bring
00:28:19.220 | fever
00:28:21.080 | attention
00:28:22.300 | interoception
00:28:23.260 | as it
00:28:23.780 | relates
00:28:24.480 | feelings
00:28:25.360 | the way
00:28:26.600 | interoception
00:28:27.140 | is most
00:28:27.580 | commonly
00:28:27.940 | described
00:28:30.000 | highlight
00:28:31.540 | probably
00:28:31.780 | heard
00:28:32.060 | which
00:28:32.740 | vagus
00:28:33.060 | nerve
00:28:33.820 | talked
00:28:34.040 | about
00:28:34.200 | vagus
00:28:34.660 | little
00:28:34.960 | earlier
00:28:36.020 | vagus
00:28:36.420 | nerve
00:28:36.900 | vagabonding
00:28:37.800 | wandering
00:28:38.280 | nerve
00:28:39.840 | involved
00:28:40.440 | everything
00:28:41.460 | talked
00:28:41.720 | about
00:28:42.320 | until
00:28:43.900 | reason
00:28:44.320 | saved
00:28:45.420 | rather
00:28:46.060 | mentioning
00:28:46.580 | along
00:28:47.640 | highlight
00:28:48.320 | specific
00:28:48.600 | point
00:28:49.000 | which
00:28:49.940 | whenever
00:28:50.480 | about
00:28:50.820 | vagus
00:28:51.500 | popular
00:28:51.860 | culture
00:28:52.780 | vagus
00:28:53.120 | calms
00:28:53.880 | it'll
00:28:54.060 | mellow
00:28:54.620 | actually
00:28:56.500 | of the
00:28:57.200 | vagus
00:28:57.660 | stimulatory
00:28:58.960 | adjust
00:28:59.240 | foods
00:29:00.440 | amino
00:29:00.680 | acids
00:29:01.000 | sugars
00:29:02.120 | fatty
00:29:02.360 | acids
00:29:03.540 | vagus
00:29:03.980 | nerve
00:29:05.680 | activated
00:29:06.500 | triggers
00:29:07.080 | release
00:29:07.460 | dopamine
00:29:07.900 | makes
00:29:08.820 | alert
00:29:10.100 | those
00:29:10.300 | foods
00:29:11.760 | those
00:29:11.960 | conditions
00:29:14.420 | nauseous
00:29:15.320 | rarely
00:29:15.620 | calming
00:29:17.100 | fever
00:29:17.720 | rarely
00:29:18.000 | calming
00:29:19.360 | you're
00:29:19.620 | starting
00:29:19.780 | to get
00:29:20.080 | picture
00:29:20.720 | though
00:29:21.060 | vagus
00:29:21.640 | nerve
00:29:23.680 | parasympathetic
00:29:24.640 | branch
00:29:25.180 | of the
00:29:25.460 | autonomic
00:29:25.880 | nervous
00:29:26.140 | system
00:29:27.260 | calming
00:29:27.660 | system
00:29:28.900 | communication
00:29:29.420 | system
00:29:31.200 | motor
00:29:31.420 | system
00:29:31.860 | communicates
00:29:32.480 | brain
00:29:33.660 | brain
00:29:34.400 | changes
00:29:35.240 | function
00:29:35.640 | different
00:29:35.880 | organs
00:29:38.720 | thing
00:29:38.900 | that's
00:29:39.080 | important
00:29:39.760 | highlight
00:29:40.920 | stress
00:29:42.380 | itself
00:29:44.560 | alter
00:29:45.240 | chemistry
00:29:46.260 | because
00:29:48.220 | shuts
00:29:49.320 | vagus
00:29:49.680 | nerve
00:29:50.300 | quiets
00:29:51.000 | neurons
00:29:51.620 | communicate
00:29:52.800 | brain
00:29:54.000 | again
00:29:54.280 | stress
00:29:55.300 | disrupt
00:29:58.680 | digestion
00:29:59.640 | lousy
00:30:00.120 | because
00:30:02.740 | shuts
00:30:03.580 | vagus
00:30:03.900 | nerve
00:30:04.760 | neurons
00:30:06.060 | doesn't
00:30:07.620 | doesn't
00:30:08.960 | signals
00:30:09.680 | brain
00:30:11.900 | throws
00:30:12.580 | chemistry
00:30:13.200 | there's
00:30:13.340 | a whole
00:30:13.560 | cascade
00:30:14.100 | effects
00:30:14.860 | vagus
00:30:15.260 | nerve
00:30:15.580 | however
00:30:17.300 | responsible
00:30:18.420 | emotion
00:30:22.700 | aggregate
00:30:24.740 | conditions
00:30:26.080 | conditions
00:30:26.920 | heart
00:30:27.740 | conditions
00:30:28.400 | breathing
00:30:28.940 | which
00:30:29.580 | includes
00:30:30.040 | diaphragm
00:30:30.540 | lungs
00:30:31.660 | takes
00:30:33.440 | collection
00:30:35.080 | information
00:30:36.540 | sends
00:30:37.220 | brain
00:30:38.100 | controls
00:30:39.600 | emotions
00:30:42.400 | might
00:30:43.000 | obvious
00:30:43.800 | people
00:30:44.960 | other
00:30:45.180 | people
00:30:45.780 | might
00:30:46.120 | totally
00:30:46.380 | crazy
00:30:47.260 | thought
00:30:47.660 | emotions
00:30:48.440 | because
00:30:48.880 | market
00:30:50.220 | invested
00:30:51.420 | because
00:30:51.840 | something
00:30:52.680 | thought
00:30:53.060 | going
00:30:53.280 | happen
00:30:54.200 | going
00:30:54.580 | happen
00:30:54.900 | whatever
00:30:56.260 | bothers
00:30:57.100 | think
00:30:57.540 | generally
00:30:58.420 | purely
00:30:58.680 | cognitive
00:30:59.180 | event
00:31:01.880 | brain
00:31:02.280 | doesn't
00:31:02.620 | really
00:31:03.880 | information
00:31:05.080 | doesn't
00:31:05.740 | directly
00:31:06.580 | information
00:31:07.200 | create
00:31:07.540 | moods
00:31:08.040 | moods
00:31:08.700 | created
00:31:09.200 | through
00:31:10.500 | heart's
00:31:10.940 | response
00:31:11.740 | reading
00:31:12.260 | headline
00:31:13.840 | change
00:31:14.480 | breathing
00:31:14.900 | that's
00:31:15.240 | caused
00:31:15.880 | someone
00:31:17.240 | telling
00:31:18.280 | actually
00:31:18.940 | they're
00:31:19.300 | interested
00:31:19.760 | spending
00:31:20.420 | anymore
00:31:20.780 | emotions
00:31:22.520 | neutral
00:31:25.200 | thing
00:31:25.800 | interoception
00:31:27.100 | sense
00:31:28.160 | building
00:31:29.520 | fundamental
00:31:30.040 | layers
00:31:30.800 | chemistry
00:31:31.460 | spleens
00:31:32.820 | immune
00:31:33.160 | systems
00:31:33.620 | autoimmune
00:31:34.200 | all of
00:31:34.880 | those
00:31:35.080 | things
00:31:35.640 | plugging
00:31:37.200 | series
00:31:37.620 | ingredients
00:31:38.580 | recipe
00:31:39.520 | gives
00:31:46.780 | shown
00:31:47.840 | location
00:31:49.220 | other
00:31:49.460 | people
00:31:50.760 | that's
00:31:51.480 | facial
00:31:51.780 | expressions
00:31:53.360 | indeed
00:31:53.600 | there
00:31:54.040 | beautiful
00:31:54.960 | showing
00:31:58.220 | including
00:32:00.120 | pupils
00:32:01.300 | tonality
00:32:02.720 | flushed
00:32:06.860 | degree
00:32:07.260 | which
00:32:07.660 | frowning
00:32:08.980 | smiling
00:32:09.560 | relative
00:32:10.600 | other
00:32:10.900 | periods
00:32:14.420 | aggregate
00:32:16.600 | reflection
00:32:17.060 | rather
00:32:18.740 | heart
00:32:19.480 | breathing
00:32:20.280 | chemistry
00:32:22.300 | what's
00:32:22.580 | remarkable
00:32:23.200 | and this
00:32:23.640 | is where
00:32:23.920 | interoception
00:32:24.540 | really
00:32:25.180 | really
00:32:25.600 | takes a
00:32:27.500 | incredible
00:32:28.020 | is that
00:32:28.940 | there are
00:32:29.380 | beautiful
00:32:29.720 | studies
00:32:30.160 | that show
00:32:30.720 | that for
00:32:31.700 | instance
00:32:32.020 | when we
00:32:33.080 | somebody
00:32:33.520 | pretty
00:32:35.100 | going
00:32:35.500 | through
00:32:36.380 | experience
00:32:38.980 | heart
00:32:39.680 | actually
00:32:40.340 | starts
00:32:40.980 | mimic
00:32:41.260 | their
00:32:41.600 | heart
00:32:42.920 | breathing
00:32:43.360 | starts
00:32:43.900 | mimic
00:32:44.100 | their
00:32:44.300 | breathing
00:32:45.380 | aren't
00:32:45.640 | conscious
00:32:46.840 | their
00:32:46.980 | breathing
00:32:47.240 | somehow
00:32:47.740 | human
00:32:48.320 | beings
00:32:49.320 | register
00:32:50.620 | internal
00:32:51.140 | state
00:32:51.780 | other
00:32:52.040 | beings
00:32:52.440 | and I
00:32:52.700 | think
00:32:52.820 | probably
00:32:53.320 | animals
00:32:54.140 | certainly
00:32:54.680 | other
00:32:54.860 | humans
00:32:56.420 | distance
00:32:58.900 | sense
00:32:59.820 | internal
00:33:00.240 | landscape
00:33:00.980 | linked
00:33:01.840 | others
00:33:03.520 | enhance
00:33:04.600 | interoceptive
00:33:05.540 | capacity
00:33:06.100 | for how
00:33:06.780 | you feel
00:33:07.400 | and how
00:33:07.800 | others
00:33:08.240 | in other
00:33:08.560 | words
00:33:09.440 | start
00:33:09.720 | getting
00:33:10.200 | better
00:33:10.460 | readout
00:33:11.900 | internal
00:33:12.280 | state
00:33:13.900 | doing
00:33:14.420 | simple
00:33:14.940 | exercise
00:33:16.640 | what is
00:33:17.180 | really
00:33:17.380 | a tool
00:33:17.960 | and that
00:33:18.960 | is to
00:33:19.400 | learn
00:33:19.860 | sense
00:33:20.380 | heartbeats
00:33:21.060 | and I
00:33:21.360 | think
00:33:22.040 | reasons
00:33:22.460 | meditation
00:33:23.160 | powerful
00:33:24.440 | taking
00:33:25.380 | exteroceptive
00:33:26.620 | information
00:33:27.100 | information
00:33:27.520 | from the
00:33:27.980 | outside
00:33:28.380 | world
00:33:28.780 | by closing
00:33:29.740 | your eyes
00:33:30.180 | and focusing
00:33:30.760 | inward
00:33:31.320 | as they
00:33:33.160 | start
00:33:33.380 | paying
00:33:33.580 | attention
00:33:34.200 | breathing
00:33:34.480 | cadence
00:33:35.540 | start
00:33:35.760 | directing
00:33:36.500 | mind's
00:33:37.080 | attention
00:33:38.760 | heart
00:33:39.960 | start
00:33:40.680 | perceive
00:33:41.480 | heart
00:33:41.760 | beating
00:33:42.960 | actually
00:33:44.560 | quickly
00:33:45.160 | strengthen
00:33:46.480 | vagal
00:33:46.980 | connections
00:33:47.600 | between
00:33:49.140 | brain
00:33:49.960 | there's
00:33:50.560 | practice
00:33:51.400 | there's
00:33:51.840 | breathe
00:33:53.560 | thing
00:33:53.840 | except
00:33:54.940 | direct
00:33:56.720 | awareness
00:33:57.120 | toward
00:33:58.320 | heartbeat
00:34:00.520 | people
00:34:03.260 | people
00:34:04.160 | doing
00:34:04.980 | minute
00:34:05.560 | every
00:34:06.460 | while
00:34:07.540 | start
00:34:09.140 | sixth
00:34:09.720 | sense
00:34:10.180 | start
00:34:10.560 | notice
00:34:12.980 | don't
00:34:13.560 | quite
00:34:13.840 | right
00:34:14.100 | about
00:34:14.320 | something
00:34:14.880 | somebody
00:34:15.660 | situation
00:34:16.780 | interoceptive
00:34:17.520 | awareness
00:34:18.340 | tuned
00:34:19.680 | called
00:34:19.840 | vagal
00:34:21.600 | think
00:34:22.320 | doesn't
00:34:23.000 | account
00:34:23.800 | other
00:34:24.020 | things
00:34:24.460 | going
00:34:25.300 | vagus
00:34:25.880 | don't
00:34:26.000 | really
00:34:27.740 | interoceptive
00:34:28.680 | awareness
00:34:31.020 | effectively
00:34:31.420 | tried
00:34:31.980 | today
00:34:33.140 | window
00:34:34.200 | incredible
00:34:34.780 | relationship
00:34:35.400 | between
00:34:36.600 | viscera
00:34:37.540 | brain
00:34:38.220 | viscera
00:34:39.280 | these
00:34:39.420 | organs
00:34:42.300 | you'll
00:34:42.620 | appreciate
00:34:44.240 | system
00:34:45.000 | aren't
00:34:45.680 | system
00:34:46.200 | tubes
00:34:48.980 | tubes
00:34:49.720 | system
00:34:50.100 | tubes
00:34:50.840 | system
00:34:51.360 | tubes
00:34:51.860 | linked
00:34:52.320 | through
00:34:53.360 | nervous
00:34:53.680 | system
00:34:54.640 | those
00:34:54.900 | links
00:34:56.280 | specific
00:34:57.300 | whether
00:34:57.800 | remember
00:34:58.300 | about
00:34:58.580 | piezos
00:35:00.880 | stuff
00:35:01.040 | doesn't
00:35:01.380 | really
00:35:01.600 | matter
00:35:02.660 | encourage
00:35:03.600 | start
00:35:05.260 | pushing
00:35:05.740 | pulling
00:35:06.280 | various
00:35:06.600 | levers
00:35:07.020 | within
00:35:07.600 | beautiful
00:35:07.940 | system
00:35:09.420 | interoceptive
00:35:10.080 | system
00:35:11.000 | sense
00:35:11.760 | thank
00:35:13.240 | attention
00:35:14.020 | thank
00:35:14.680 | interest
00:35:15.200 | science