E60: The 2021 Bestie Awards PLUS Jack Dorsey starts the Web3 Wars

Hey, everybody, welcome to another episode of the all in podcast. And it is our year end episode. It is our 2021 Bestie Awards. This is where we give our awards for the best and worst of what happened in 2021. We did it last year, kind of halfheartedly. But this year, hopefully we put a little bit more work into it with me again, of course, David Friedberg, the Sultan of Science, the Rain Man, David Sachs and sweater Jesus Chamath polyhapitia.

How's everybody doing? Ready to go? Did anybody do their homework? Oh, my God. We are nine away from episode 69. And where we will have a special guest, special guest who I've given the choice of coming on episode 69. Or 420. No, no, no, he has to do 69.

He can do for 20. He can do both. He can do whatever he wants. I basically could do no wrong. Is he committed? What about jack? Can we get jack on? Don't talk about that. If you stop grinding jack? Yeah. Yeah. Maybe if you stop dunking on jack for no reason, you insufferable sacks.

Seriously, you'd suffer enough that like I've alienated potential guests Chamath alienated best now you're getting in on alienating the guests. You think it would be too much to have Jack and Chris Dixon on together? Who? Who? Oh, my God. That is so gross. Delete that. No, don't look at free.

I don't care about my relationship with AC sixteen. Jack Dorsey. We all know who who's the other person? Dick Chris Dixon. Chris Dixon. Yeah, who's a general partner at Andreessen Horowitz who runs their crypto fund? Oh, nice. It wasn't just me. I mean, very vocal lately about web three.

Why don't you guys invite the CFO of Greylock as well while you're at it? We couldn't get the partner in charge of human capital at Excel. You're getting a little bit far afield. Chris posted something pretty innocuous on web three and Jack jumped down his throat and same thing with biology as well.

I saw that. I saw the C Dixon quote. It wasn't just me. Jason, now you're pretending. You retweeted a photo of Jack jumping down Chris Dixon's throat and saying, whoa, what's going on here? Now, you're trying to pretend. I love Jack. Now, you're trying to pretend like he was triggered by me.

He wasn't triggered by. He's been Jack after dark. Jack is gone wild. Chris Dixon did did try a little misappropriation. For which Jack jumped down his throat. Basically, ever since Horowitz's thing, they always culture appropriate, right? Like Jack is just like any other guy who quits his job and then goes on a shitposting rampage.

And really like you did. Like Jamal did after shutting down. I'm just one of his casualties. There's a bunch of people he's gone. I thought energy was great. I think he quit. I think it's great to have Twitter so he could tweet. Yeah, he wanted to get in there.

No, he wants to focus on blockchain. Clearly, he has religion on this and he believes that it's the future of the internet and he cares deeply about the democratization of access to finance. And I think it would be awesome to hear his views on this. I would love for him to come on and not be badgered about censorship in the role that he used to run.

How would you like him talking to you about, you know, being the CEO of Zenefits sacks? Like, you know, I'm not trying to badger him. I only have one question, which is the reason why he loves Bitcoin is for censorship resistance. So why when he had the opportunity as CEO of Twitter, didn't he stand tall for resisting censorship?

Maybe he did. Okay, so just tell us that read between the lines, dude. I don't think he has to. I don't think he has to. I don't think he has to answer to the Twitter mob and try to say, here's all the hard decisions I made that you guys didn't see.

You know this. There's a, there's a. The dynamics of a board and lawsuits and politicians. Hundreds of hard decisions that CEOs make. And the president inciting a riot at the Capitol. You're not supposed to create a list and publish it and say, look at me, I'm such a good boy.

I mean, it's not unreasonable. I just think it's a reasonable question for me to ask. Yeah, but the way you asked it was like, isn't Jack at an ashram, like praying, like you're full dunk mode. I know that's one of your comedy writers writing those tweets for you. Did you get, was that a punched up tweet or not?

No. It was a punched up tweet. I felt punched up. I can't actually be funny. No, it was not punched up. It felt funnier than you actually are. That's why I'm saying so. And an ashram? Why did you have to throw my people in the mix? Yeah, why'd I have to go to the ashram?

Yeah. Why are you in Kent? Jack has spent years trying to cultivate this like Zen approach. That has nothing to do with my people, bro. Nothing to do. Nothing to do with an ashram. Yeah. We're getting lost in the weeds here. We have an award show to do. You can apologize later.

Do you have a music intro? We got an important show to do. Please welcome everybody to the 2021 Bestie Awards. Now just put in like everybody like Denzel Washington and you know, like, Yeah, can we edit screenshots from like the last Oscars? You know, everyone's in our audience. Okay.

Oscars from the eighties. Like Tom Cruise getting up and cheering and whooping. Okay, here we go. Let your winners ride. Rain Man, David Sasson. And it said we open source it to the fans and they've just gone crazy with it. Love you best. Queen of Kinwa. So there's a lot at stake here, folks.

And we're going to start it off with biggest winner in politics. A very difficult decision here. Saks, biggest winner in politics. Who do you got? I got Eric Adams, the new mayor of New York City. He was a huge underdog candidate. He won by not being woke. He rejected the.

You know, woke sensibilities of the other Democratic candidates. He is a former cop who still packs a gun and he made his issues supporting the police, public safety, charter schools, you know, as an instrument of minority advancement. And he even pushed to make New York City a tech and crypto hub.

He is going to reverse the damage done under de Blasio. He won four or five boroughs, the Democratic primary and overwhelmingly carried black Latino precincts. If the Democratic Party has a future. I'm going to be a Democrat. I'm going to be a Democrat. I'm going to be a Democrat.

I'm going to be a Democrat. I'm going to be a Democrat. I'm going to be a Democrat. I'm going to be a Democrat. I'm going to be a Democrat. I'm going to be a Democrat. I'm going to be a Democrat. I think I mentioned this on the show a few weeks ago, and I'm spending quite a bit of time at work on it, which is that starch synthesis system that was demonstrated by those Chinese scientists.

And the system itself is likely not going to be the production system that saves the world. But the concept that we can take proteins that are expressed by different plants and put them together in a tank, and then that tank can convert molecules from one form to another. And then that tank can convert molecules from one form to another.

And then that tank can convert molecules from one form to another. And then that tank can convert molecules from one form to another. And then that tank can convert molecules from one form to another. And then that tank can convert molecules from one form to another. And then that tank can convert molecules from one form to another.

And then that tank can convert molecules from one form to another. And then that tank can convert molecules from one form to another. By leveraging these proteins that just interact and move around in the tank, it's really an incredible demonstration. And the demonstration is inspiring. We can take carbon out of the atmosphere and make food with a minimal amount of renewable electricity.

And I think that's really a moment that will inspire a whole new realm of industrial synthetic biology work, a lot of which I hope to kind of, you know, build and participate in pretty heavily in the work that we do day to day. But it was really exciting for me.

So the starch synthesis system. So the starch synthesis system is your best science breakthrough. What do you got, Sax? I've got these new oral COVID antiviral pills that are coming out from Pfizer and Merck. The FDA is supposed to be approving them by the end of this week. As you recall, last year around this time, it was these new mRNA vaccines from Pfizer and Moderna.

But we now have to admit that the vaccines have not ended the pandemic because the virus can mutate its spike proteins around the vaccine. So the vaccines by itself are not going to be able to mutate. So the vaccines by itself cannot end the pandemic. These new pills have, I think, a very good shot of doing it next year because they're protease inhibitors.

So they stop the virus from replicating. And just even if the spike proteins mutate, it will not prevent these protease inhibitors from working. So I am hopeful that this will be the thing hopefully that ends the pandemic next year are these new antiviral pills. Great one. I would like to make a counter to Sax's.

Oh, point. I would be very cautious about the side effects that are going to arise from these protease inhibitors. And, you know, they're not as well studied as they normally would be, but there are, they have a serious biological effect in normal cells in the human body. And I think as more people use them, you'll see more crazy stories about side effects that are really significant.

What do you think the side effects would be? There's a lot that are well documented, but the way they work biologically is they disrupt, you know, certain systems. And those are not just systems related to the virus. They're systems in our own cells. And so I'm personally quite nervous about them.

I know that folks are pretty encouraged by them and excited, but I'm nervous about them. There's a similar medication that's been developed for HIV, right? That's called PrEP, right? Does that cause similar side effects or because people use that prophylactically? Yeah, to some extent, you know, and the dosage matters.

And so normally, you would go through many more years, I think of testing on these things to kind of truly quantify. But I think, you know, when you have half a percent or 1% of a population, you know, let's say take the most extreme case die, then a million people use it, you're gonna have a lot of people dying.

And I'm not sure we've really gotten the boundaries of this yet. And the dosage is pretty significant on them. So yeah, like, let's, you know, let's keep a watchful eye on this stuff. But I'm hopeful, but I'm also nervous. Well, hopefully, the number of people who need to take it, Freiburg, correct me if I'm wrong, if we've got this many people vaxxed who will not need to take it.

And then Omicron, my biggest optimism is that Omicron is a much less virulent virus, and it sweeps through the population. And we slowly see this pandemic kind of, you know, becoming less severe, which is what was predicted. Do you think herd immunity even exists? In the way that the virus evolves?

No. So there, and by the way, it's not binary. It's not like, hey, you get herd immunity, and no one's gonna catch this thing. There's clearly a spectrum of immunity. Meaning like, you know, you're gonna get a lot of immunity. And then you're gonna get the virus. And then you're gonna get the virus.

And then you're gonna get the virus. And then you're gonna get the virus. And then you're gonna get the virus. And then you're gonna get the virus. And then you're gonna get the virus. And then you're gonna get the virus. And then you're gonna get the virus. And then you're gonna get the virus.

And then you're gonna get the virus. And then you're gonna get the virus. I picked Ford. Enormous performance. This year the stock's up 130 odd percent. Good portfolio mix of gas guzzling cars that still make a ton of money like the Ford F-150s. But they have the Mustang. They have electric versions of the Ford F-150s.

They had some great investments. I think they printed like a $20 billion gain on Rivian. So it's just really, really good. Turnaround from what that company was, which was if you talked any car company that could have been up 132% at the beginning of 2021, it would not have been Ford.

So well done by that team. Who do you have? Sachs. Are you an investor in Fortuna? No. No. So I went a little different for this. I said the best turnaround was Kyle Rittenhouse's reputation. As you recall, Rittenhouse shot three white attackers, including two of them were sex offenders at a violent...

BLM protests in Kenosha. The media then painted him without any evidence as a white supremacist terrorist who went there looking to shoot people like some sort of frustrated school shooter. It turned out not to be true. There was clear video evidence at the scene that he acted in self-defense.

Once there was a jury trial, all of this came out. He was acquitted on all charges and the prosecution was revealed to be politically motivated. I would say that Rittenhouse now has his freedom and he has a reputation back in the office. He's a man of his word. He's a man of his word.

And he's a man of his word. He's a man of his word. He's a man of his word. He's a man of his word. He's a man of his word. He's a man of his word. And he's a man of his word. He's a man of his word. He's a man of his word.

He's a man of his word. He's a man of his word. He's a man of his word. He's a man of his word. He's a man of his word. He's a man of his word. He's a man of his word. He's a man of his word. He's a man of his word.

He's a man of his word. He's a man of his word. He's a man of his word. He's a man of his word. He's a man of his word. He's a man of his word. He's a man of his word.

E60: The 2021 Bestie Awards PLUS Jack Dorsey starts the Web3 Wars

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